The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Functional Significance of Zinc-Related Signaling Pathways in Immune Cells
Abstract
Recent years have brought a paradigm shift for the role of the essential trace element zinc in immunity. Although its function as a structural component of many enzymes has been known for decades, current experimental evidence points to an additional function of the concentration of free or loosely bound zinc ions as an intracellular signal. The activity of virtually all immune cells is modulated by zinc in vitro and in vivo. In this review, we discuss the interactions of zinc with major signaling pathways that regulate immune cell activity, and the implications of zinc deficiency or supplementation on zinc signaling as the molecular basis for an effect of zinc on immune cell function.
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Citations
Cites
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Reprogramming of the immune system during zinc deficiency
Fraker, P. J., & King, L. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132454 · Cited by 470
Cited by
The Essential Toxin: Impact of Zinc on Human Health
Plum, L. M., Rink, L., & Haase, H. (2010) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph7041342 · Cited by 1,577
Self-citationKambe, T., Tsuji, T., Hashimoto, A., & Itsumura, N. (2015) · Physiological Reviews · doi:10.1152/physrev.00035.2014 · Cited by 1,158
A Molecular Mechanism for Bacterial Susceptibility to Zinc
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Ion channels and transporters in lymphocyte function and immunity
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The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens
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ZIP8 Regulates Host Defense through Zinc-Mediated Inhibition of NF-κB
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The immune system and the impact of zinc during aging
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Self-citationMaywald, M., Wessels, I., & Rink, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102222 · Cited by 309
Zinc homeostasis and neurodegenerative disorders
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Haase, H., & Rink, L. (2014) · Metallomics · doi:10.1039/c3mt00353a · Cited by 237
Self-citationZinc: Dietary intake and impact of supplementation on immune function in elderly
Mocchegiani, E., Romeo, J., Malavolta, M., Costarelli, L., Giacconi, R., Diaz, L.-E., & Marcos, A. (2013) · AGE · doi:10.1007/s11357-011-9377-3 · Cited by 198
Regulation of T cell receptor signaling by activation-induced zinc influx
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Neurulation and neurite extension require the zinc transporter ZIP12 ( slc39a12 )
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Self-citationDietary zinc and the control of Streptococcus pneumoniae infection
Eijkelkamp, B. A., Morey, J. R., Neville, S. L., Tan, A., Pederick, V. G., Cole, N., Singh, P. P., Ong, C.-L. Y., Gonzalez de Vega, R., Clases, D., et al. (2019) · PLOS Pathogens · doi:10.1371/journal.ppat.1007957 · Cited by 64
Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis
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Metadata
- Authors
- Haase, H., & Rink, L.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2009-08-01
- Volume
- 29
- Issue
- 1
- Pages
- 133-152
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2129991688
- Cited by
- 326
- References
- 4
- FWCI
- 2.66
- Type
- journal article
- Language
- en
- Open access
- closed
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