Cited by 1,272Bone Metabolism and DiseasesBone health and osteoporosis researchBone health and treatments

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Disorders of Bone Remodeling

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Feng, Xu, McDonald, Jay M.·2011·Annual Review of Pathology: Mechanisms of Disease

DOI 10.1146/annurev-pathol-011110-130203PMC PMC3571087

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Abstract

The skeleton provides mechanical support for stature and locomotion, protects vital organs, and controls mineral homeostasis. A healthy skeleton must be maintained by constant bone modeling to carry out these crucial functions throughout life. Bone remodeling involves the removal of old or damaged bone by osteoclasts (bone resorption) and the subsequent replacement of new bone formed by osteoblasts (bone formation). Normal bone remodeling requires a tight coupling of bone resorption to bone formation to guarantee no alteration in bone mass or quality after each remodeling cycle. However, this important physiological process can be derailed by a variety of factors, including menopause-associated hormonal changes, age-related factors, changes in physical activity, drugs, and secondary diseases, which lead to the development of various bone disorders in both women and men. We review the major diseases of bone remodeling, emphasizing our current understanding of the underlying pathophysiological mechanisms.

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Detyrosinated Glu-tubulin is a substrate for cellular Factor XIIIA transglutaminase in differentiating osteoblasts
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“abundant protein in vertebrates and constitutes approximately 30 % of the weight of bone (Feng and McDonald 2011).”
Background
Effects of Sparganii Rhizoma on Osteoclast Formation and Osteoblast Differentiation and on an OVX-Induced Bone Loss Model
Lee, S., Kim, M., Hong, S., Kim, E. J., Kim, J., Sohn, Y., & Jung, H. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.797892 · Cited by 12
“Additionally, excessive activity of osteoclasts is increased or when the two factors act at the same time (Feng and McDonald, 2011).”
Background
Transcriptome Profiling of Osteoblasts in a Medaka (Oryzias latipes) Osteoporosis Model Identifies Mmp13b as Crucial for Osteoclast Activation
Liu, R., Imangali, N., Ethiraj, L. P., Carney, T. J., & Winkler, C. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.775512 · Cited by 11
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“An imbalance between bone formation and bone resorption during bone remodeling leads to bone metabolic diseases such as osteoporosis, osteopetrosis, and osteopenia [5].”
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Effect of Menin Deletion in Early Osteoblast Lineage on the Mineralization of an In Vitro 3D Osteoid-like Dense Collagen Gel Matrix
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“in bone mass and microarchitecture deterioration of bone tissue, often leading to different levels of deterioration at different skeletal sites [1].”
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miRNA-27a is essential for bone remodeling by modulating p62-mediated osteoclast signaling
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“Dysregulation of bone remodeling causes metabolic disorders, e.g., osteop-etrosis, osteoporosis, and Paget’s disease ( Feng and McDonald, 2011 ).”
Insights into the Mechanism of Osteoporosis and the Available Treatment Options
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Impact of omeprazole on bone remodeling in normal and ovariectomized Wistar rats.
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Capturing microscopic features of bone remodeling into a macroscopic model based on biological rationales of bone adaptation
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“…bone, postmenopausal osteoporosis, and secondary osteoporosis with specific causes such as rheumatoid arthritis, glucocorticoid use, and endocrine disorders (Hirayamaet al. 2002;Canalis 2003; Fattore et al. 2008; Mosekilde 2008; Frenkel et al. 2010; Feng and McDonald 2011; Redlich and Smolen 2012).”
C/EBPα transcription factor is regulated by the RANK cytoplasmic 535IVVY538 motif and stimulates osteoclastogenesis more strongly than c-Fos
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“As such, deregulated OC differentiation has been regarded among the main causes of many osteolytic bone disorders (4, 5).”
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The positive association of total protein intake with femoral neck strength (KNHANES IV)
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Background
Benzo(a)pyrene reduces osteoclast and osteoblast activity in ex-vivo scales of zebrafish (Danio rerio[Hamilton-Buchanan, 1822]) and goldfish (Carassius auratus[Linnaeus, 1758])
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Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss
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“Osteoclastic bone resorption and osteoblastic bone formation maintain bone homeostasis together (Feng and McDonald, 2011), thus some experiments on osteogenesis in BMSCs were performed as a supplement.”
Background
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Liu, F., Xue, L., Li, X., Liu, J., Xie, C., Chen, C., & Liu, Y. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.110479 · Cited by 12
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Importance of Biomaterials In Vivo Microenvironment pH (μe-pH) in the Regeneration Process of Osteoporotic Bone Defects
Liu, W., Dan, X., Lu, W. W., & Pan, H. (2017) · Springer series in biomaterials science and engineering · doi:10.1007/978-981-10-5975-9_11 · Cited by 12
Effect of phenolic extracts from different extra-virgin olive oil varieties on osteoblast-like cells
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The Extract of Ramalina litoralis Inhibits Osteoclast Differentiation
Lee, Y., Jeong, M., Kim, K., Baek, S.-H., Hur, J., & Son, Y. (2018) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-018-0407-1 · Cited by 11
Staphylococcus aureus enhances osteoclast differentiation and bone resorption by stimulating the NLRP3 inflammasome pathway
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“Bone formation is a dynamic physiological process regulated by osteoclasts (mediators of bone resorption) and osteoblasts (mediators of bone formation) [17].”
Background
Dancr-BRG1 regulates Nfatc1 transcription and Pgc1β-dependent metabolic shifts in osteoclastogenesis
Zhang, Z., Meng, Y., Lin, T., Zhang, Z., Tao, Z., Yin, H.-Z., Yang, F., & Zhou, X. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2313656121 · Cited by 11
“Human bone undergoes constant remodeling maintained by osteoblast - mediated bone formation and osteoclast - mediated bone resorption (1).”
Background
A p38 MAP kinase inhibitor suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss through the inhibition of bone turnover
Xu, C., Wei, Z., Dong, X., Xing, J., Meng, X., Qiu, Y., Zhou, H., Zheng, W., Xu, Z., Huang, S., et al. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116391 · Cited by 11
Imbalanced Skeletal Muscle Mitochondrial Proteostasis Causes Bone Loss
Jin, Z., Mao, Y., Guo, Q., Yin, Y., Kiram, A., Zhou, D., Yang, J., Zhou, Z., Xue, J., Feng, Z., et al. (2024) · Research · doi:10.34133/research.0465 · Cited by 13
“Osteoporosis, a degenerative disorder associated with aging, manifests as reduced bone mass, micro-architectural degradation, and an increased susceptibility to hip fractures [1].”
Background
Synthetic Vesicle-Based Drug Delivery Systems for Oral Disease Therapy: Current Applications and Future Directions
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“Bone restoration and regeneration are dynamic processes that repair minor bone defects or reunite minor fracture parts [225].”
Rat-tail tendon fiber SAXS high-order diffraction peaks recovered by a superbright laboratory source and a novel restoration algorithm
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“…progressive hearing loss and kidney problems (Kashtan, 1993), osteoporosis, characterized by bone loss and increased risk of fracture (Shuster, 2005; Feng & McDonald, 2011), and Knobloch syndrome, where retina degeneration causes extreme nearsightedness (high myopia) (Mahajan et al., 2010), to…”
Background
Modulating calcium‐mediated NFATc1 and mitogen‐activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption
Guo, Q., Cao, Z., Wu, B., Chen, F., Tickner, J. C., Wang, Z., Qiu, H., Wang, C., Chen, K., Tan, R. X., et al. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26893 · Cited by 11
“Currently, several antiresorption drugs which inhibit the osteoclast‐mediated bone resorption are widely used in the clinic; however, limitations to the treatment of osteoporosis still exist (X. Feng & McDonald, 2011; Knopp‐Sihota, Cummings, Homik, & Voaklander, 2013; T. Wang et al., 2017).”
Background
BCPA {N,N′-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]} Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-Prolyl cis-trans Isomerase Never in Mitosis A-Interacting 1
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“However, bone loss occurs due to imbalance of osteoblast and osteoclast activity, which causes osteoporosis and increases the risk of fracture [30,31].”
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The effect of fructan-enriched diet on bone turnover parameters in ovariectomized rats under calcium restriction
Topolska, K., Bieńko, M., Filipiak‐Florkiewicz, A., Radzki, R. P., & Cieśłik, E. (2019) · Annals of Agricultural and Environmental Medicine · doi:10.26444/aaem/108658 · Cited by 11
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Convenient synthesis of zwitterionic calcium(II)-carboxylate metal organic frameworks with efficient activities for the treatment of osteoporosis
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Authors: Feng, X., & McDonald, J. M.
Affiliations: University of Alabama at Birmingham (US)
ORCID: Feng, Xu
Venue: Annual Review of Pathology: Mechanisms of Disease
Publisher: Annual Reviews
Published: 2011-02-28
Volume: 6
Issue: 1
Pages: 121-145
ISSN: 1553-4006 (ISSN-L)
1553-4014
DOI: 10.1146/annurev-pathol-011110-130203
PMC: PMC3571087
OpenAlex: W2166266977
Cited by: 1,272
References: 171
Citations by year: 2026: 59 · 2025: 109 · 2024: 102 · 2023: 124 · 2022: 135 · 2021: 142 · 2020: 107 · 2019: 117 · 2018: 86 · 2017: 68 · 2016: 59 · 2015: 47 · 2014: 36 · 2013: 37 · 2012: 29
FWCI: 3.28
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Annual Review of Pathology Mechanisms of Disease (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA109119)
National Institute of Neurological Disorders and Stroke (R21NS061677, NS061677)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (5P30 AR0406031, R01AR047830, AR 47830, R01AR050235)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords: bone remodeling, bone resorption, bone formation, osteoclasts, osteoblasts, bone disease, menopause, hormonal changes, age-related bone loss, physical activity, drug-induced bone loss, mineral homeostasis, pathophysiology
MeSH terms: Animals, Bone Diseases, Humans, Bone Remodeling

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