The DOI matches its Crossref record; 272 of the 272 references it cites were found in a registry or an index.
The Multifaceted Functions of Neutrophils
Open accessAbstract
Neutrophils and neutrophil-like cells are the major pathogen-fighting immune cells in organisms ranging from slime molds to mammals. Central to their function is their ability to be recruited to sites of infection, to recognize and phagocytose microbes, and then to kill pathogens through a combination of cytotoxic mechanisms. These include the production of reactive oxygen species, the release of antimicrobial peptides, and the recently discovered expulsion of their nuclear contents to form neutrophil extracellular traps. Here we discuss these primordial neutrophil functions, which also play key roles in tissue injury, by providing details of neutrophil cytotoxic functions and congenital disorders of neutrophils. In addition, we present more recent evidence that interactions between neutrophils and adaptive immune cells establish a feed-forward mechanism that amplifies pathologic inflammation. These newly appreciated contributions of neutrophils are described in the setting of several inflammatory and autoimmune diseases.
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“Neutrophils act as the first-line of defense via secretion of various inflammatory substances, for example, cytokines which damage the cellular DNA through phagocytic and apoptotic effect.[18]”
From Comparison of NLR (neutrophil/lymphocyte ratio) and PLR (platelet/lymphocyte ratio) as inflammatory markers in 1st episode mania and bipolar mania: A preliminary study (2023) · cites this paper as [18]
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Cites
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Sorted by citations
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types?
Rosales, C. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00113 · Cited by 1,334
Neutrophil ageing is regulated by the microbiome
Zhang, D., Chen, G., Manwani, D., Mortha, A., Xu, C., Faith, J. J., Burk, R. D., Kunisaki, Y., Jang, J.-E., Scheiermann, C., et al. (2015) · Nature · doi:10.1038/nature15367 · Cited by 839
Neutrophil-derived cytokines: facts beyond expression
Tecchio, C., Micheletti, A., & Cassatella, M. A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00508 · Cited by 699
Neutrophil-to-lymphocyte ratio and mortality in the United States general population
Song, M., Graubard, B. I., Rabkin, C. S., & Engels, E. A. (2021) · Scientific Reports · doi:10.1038/s41598-020-79431-7 · Cited by 434
Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442
Metadata
- Authors
- Mayadas, T. N., Cullere, X., & Lowell, C. A.
- Affiliations
- Brigham and Women's Hospital (US)
- Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 20115;
- University of California, San Francisco (US)
- Venue
- Annual Review of Pathology: Mechanisms of Disease
- Publisher
- Annual Reviews
- Published
- 2014-01-24
- Volume
- 9
- Issue
- 1
- Pages
- 181-218
- ISSN
- 1553-4006 (ISSN-L)
- 1553-4014
- PMC
- PMC4277181
- OpenAlex
- W2110299641
- Semantic Scholar
- 01859ca9e892596fabdb4f985c59273d14711994
- Cited by
- 1,356
- References
- 272
- Citations by year
- 2026: 76 · 2025: 132 · 2024: 149 · 2023: 117 · 2022: 137 · 2021: 146 · 2020: 144 · 2019: 115 · 2018: 87 · 2017: 92 · 2016: 78 · 2015: 53 · 2014: 27
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Pathology Mechanisms of Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL065095, HL036028, P01HL036028, R01HL065095)
- National Institute of Allergy and Infectious Diseases (AI068150, AI078869, R01AI068150, AI 065495, P01AI078869, R01AI065495)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR054984, AR 050800, R01AR050800, K01AR054984)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
- Health Sciences › Medicine › Hematology › Blood disorders and treatments
- Keywords
- neutrophils, neutrophil-like cells, phagocytosis, reactive oxygen species, antimicrobial peptides, neutrophil extracellular traps, neutrophil cytotoxicity, tissue damage, inflammation, autoimmune disease, innate immunity
- MeSH terms
- Animals, Extracellular Matrix, Homeostasis, Humans, Infections, Inflammation, Neutrophils, Phagocytosis, Reactive Oxygen Species, Neutrophil Activation, Neutrophil Infiltration, Adaptive Immunity
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