The Multifaceted Functions of Neutrophils

Neutrophil Extracellular Traps Kill Bacteria

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Neutrophil recruitment and function in health and inflammation

Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472

Getting to the site of inflammation: the leukocyte adhesion cascade updated

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Circulating mitochondrial DAMPs cause inflammatory responses to injury

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Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

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Novel cell death program leads to neutrophil extracellular traps

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Neutrophils in the activation and regulation of innate and adaptive immunity

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NOX enzymes and the biology of reactive oxygen

Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125

Genomic responses in mouse models poorly mimic human inflammatory diseases

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Extracellular DNA traps promote thrombosis

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Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood

Clark, S. R., Ma, A. C., Tavener, S. A., McDonald, B., Goodarzi, Z., Kelly, M. M., Patel, K. D., Chakrabarti, S., McAvoy, E., Sinclair, G. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1565 · Cited by 2,309

Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps

Papayannopoulos, V., Metzler, K. D., Hakkim, A., & Zychlinsky, A. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201006052 · Cited by 2,103

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

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Neutrophil Function: From Mechanisms to Disease

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Netting neutrophils in autoimmune small-vessel vasculitis

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Neutrophils, from Marrow to Microbes

Borregaard, N. (2010) · Immunity · doi:10.1016/j.immuni.2010.11.011 · Cited by 1,679

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

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Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

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PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

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Immune and Inflammatory Mechanisms of Atherosclerosis

Galkina, E., & Ley, K. F. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132620 · Cited by 1,480

Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus

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Cooperation of Toll-like receptor signals in innate immune defence

Trinchieri, G., & Sher, A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2038 · Cited by 1,394

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA–Peptide Complexes in Systemic Lupus Erythematosus

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MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

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Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.

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Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

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Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

Kaplan, M. J., & Radic, M. Z. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201719 · Cited by 1,214

Intravascular Danger Signals Guide Neutrophils to Sites of Sterile Inflammation

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Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

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Neutrophil granules and secretory vesicles in inflammation

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TREM-1 amplifies inflammation and is a crucial mediator of septic shock

Bouchon, A., Facchetti, F., Weigand, M. A., & Colonna, M. (2001) · Nature · doi:10.1038/35074114 · Cited by 1,092

Intracellular NOD-like Receptors in Host Defense and Disease

Kanneganti, T., Lamkanfi, M., & Núñez, G. (2007) · Immunity · doi:10.1016/j.immuni.2007.10.002 · Cited by 1,087

Neutrophil extracellular traps: Is immunity the second function of chromatin?

Brinkmann, V., & Zychlinsky, A. (2012) · Journal of Cell Biology · doi:10.1083/jcb.201203170 · Cited by 1,021

An integrated model of the recognition of Candida albicans by the innate immune system

Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946

Phagocytosis of Apoptotic Neutrophils Regulates Granulopoiesis via IL-23 and IL-17

Stark, M. A., Huo, Y., Burcin, T. L., MORRIS, M. A., Olson, T. S., & Ley, K. F. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.011 · Cited by 945

Toll-like receptors stimulate human neutrophil function

Hayashi, F., Means, T. K., & Luster, A. D. (2003) · Blood · doi:10.1182/blood-2003-04-1078 · Cited by 939

Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

Nozawa, H., Chiu, C. W., & Hanahan, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601807103 · Cited by 926

Properties of mouse and human IgG receptors and their contribution to disease models

Bruhns, P. (2012) · Blood · doi:10.1182/blood-2012-01-380121 · Cited by 905

In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days

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A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1

Pillay, J., Kamp, V. M., van Hoffen, E., Visser, T., Tak, T., Lammers, J. J., Ulfman, L. H., Leenen, L. P. H., Pickkers, P., & Koenderman, L. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57990 · Cited by 829

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

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Tumor entrained neutrophils inhibit seeding in the premetastatic lung

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Neutrophil elastase–mediated degradation of IRS-1 accelerates lung tumor growth

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ICAM-1 regulates neutrophil adhesion and transcellular migration of TNF-α-activated vascular endothelium under flow

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B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen

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Tumor-associated neutrophils: friend or foe?

Fridlender, Z. G., & Albelda, S. Μ. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs123 · Cited by 729

Mechanical modes of ‘amoeboid’ cell migration

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Tumor-Associated Neutrophils: New Targets for Cancer Therapy

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Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis

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Phagosome maturation: aging gracefully

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A review of activity indices and efficacy endpoints for clinical trials of medical therapy in adults with Crohn's disease

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A transmigratory cup in leukocyte diapedesis both through individual vascular endothelial cells and between them

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The chemotactic receptor for human C5a anaphylatoxin

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Molecular determinants of crosstalk between nuclear receptors and toll-like receptors

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NETs: a new strategy for using old weapons

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Tumor associated macrophages and neutrophils in cancer

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Neutrophils cascading their way to inflammation

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Dynamic interaction of VCAM-1 and ICAM-1 with moesin and ezrin in a novel endothelial docking structure for adherent leukocytes

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An Endonuclease Allows Streptococcus pneumoniae to Escape from Neutrophil Extracellular Traps

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Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response

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Neutrophil kinetics in man.

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The Ins and Outs of Leukocyte Integrin Signaling

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Activated endothelial cells induce neutrophil extracellular traps and are susceptible to NETosis‐mediated cell death

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Enhancement of Hematopoietic Stem Cell Repopulating Capacity and Self-Renewal in the Absence of the Transcription Factor C/EBPα

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Neutrophil Extracellular Traps That Are Not Degraded in Systemic Lupus Erythematosus Activate Complement Exacerbating the Disease

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Multiple Roles for Neutrophils in Atherosclerosis

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Inflammation: Basic Principles and Clinical Correlates

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Phenotype of Mice and Macrophages Deficient in Both Phagocyte Oxidase and Inducible Nitric Oxide Synthase

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P-Selectin or Intercellular Adhesion Molecule (Icam)-1 Deficiency Substantially Protects against Atherosclerosis in Apolipoprotein E–Deficient Mice

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HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

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Transcellular Diapedesis Is Initiated by Invasive Podosomes

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Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma

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Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

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Molecular mechanism of antimicrobial peptides: The origin of cooperativity

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Anti-inflammatory activity of IgG1 mediated by Fc galactosylation and association of FcγRIIB and dectin-1

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Crosstalk between neutrophils, B-1a cells and plasmacytoid dendritic cells initiates autoimmune diabetes

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TREM and TREM-like receptors in inflammation and disease

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Molecular definition of distinct cytoskeletal structures involved in complement- and Fc receptor-mediated phagocytosis in macrophages.

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C/EBPβ is required for 'emergency' granulopoiesis

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Getting Leukocytes to the Site of Inflammation

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Demand-adapted regulation of early hematopoiesis in infection and inflammation

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Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

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Infectious Diseases in Patients with IRAK-4, MyD88, NEMO, or IκBα Deficiency

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Neutrophils mediate immune modulation of dendritic cells through glycosylation-dependent interactions between Mac-1 and DC-SIGN

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Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis

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In vivo two-photon imaging reveals monocyte-dependent neutrophil extravasation during pulmonary inflammation

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A minimal role for selectins in the recruitment of leukocytes into the inflamed liver microvasculature.

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Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation

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Immunoreceptor tyrosine-based inhibition motifs

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Integrin signaling in neutrophils and macrophages uses adaptors containing immunoreceptor tyrosine-based activation motifs

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On the dual roles and polarized phenotypes of neutrophils in tumor development and progression

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Pathogenesis of human systemic lupus erythematosus: recent advances

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Transiently Entrapped Circulating Tumor Cells Interact with Neutrophils to Facilitate Lung Metastasis Development

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