The DOI matches its Crossref record; 194 of the 194 references it cites were found in a registry or an index.
Cell Death in the Lung: The Apoptosis–Necroptosis Axis
Open accessAbstract
Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; however, new modalities of caspase-independent regulated cell death have been identified, including necroptosis, pyroptosis, and autophagic cell death. As an understanding of the cellular mechanisms that mediate regulated cell death continues to grow, there is increasing evidence that these pathways are implicated in the pathogenesis of many pulmonary disorders. This review summarizes our understanding of regulated cell death as it pertains to the pathogenesis of chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, acute respiratory distress syndrome, and pulmonary arterial hypertension.
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Cites
Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
Kerr, J. F. R., Wyllie, A. H., & Currie, A. R. (1972) · British Journal of Cancer · doi:10.1038/bjc.1972.33 · Cited by 15,725
Apoptosis: A Review of Programmed Cell Death
Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853
Thornberry, N. A., & Lazebnik, Y. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,887
Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Shi, J., Zhao, Y., Wang, K., Shi, X., Wang, Y., Huang, H., Zhuang, Y., Cai, T., Wang, F., & Shao, F. (2015) · Nature · doi:10.1038/nature15514 · Cited by 6,659
Oxyl radicals, redox-sensitive signalling cascades and antioxidants
Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930
Autophagy in Human Health and Disease
Choi, A. M. K., Ryter, S. W., & Levine, B. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1205406 · Cited by 2,583
Programmed Cell Death in Animal Development and Disease
Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915
Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
Oberst, A., Dillon, C. P., Weinlich, R., McCormick, L. L., Fitzgerald, P., Pop, C., Hakem, R., Salvesen, G. S., & Green, D. R. (2011) · Nature · doi:10.1038/nature09852 · Cited by 1,278 · cited 23×
“RIPK3 expression is increased in IPF alveolar epithelial cells, and Ripk3-deficient mice have attenuated fibrosis and decreased HMGB1 in a bleomycin model of IPF (127).”
BackgroundInfluentialMechanisms of Cell Death in Oxidative Stress
Ryter, S. W., Kim, H. P., Hoetzel, A., Park, J. W., Nakahira, K., Wang, X., & Choi, A. M. K. (2007) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.9.49 · Cited by 1,261
Cited by
Hough, K. P., Curtiss, M. L., Blain, T. J., Liu, R.-M., Trevor, J., Deshane, J. S., & Thannickal, V. J. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.00191 · Cited by 432
Necroptosis: a crucial pathogenic mediator of human disease
Choi, M. E., Price, D. R., Ryter, S. W., & Choi, A. M. K. (2019) · JCI Insight · doi:10.1172/jci.insight.128834 · Cited by 419
Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells
Shu, L., Niu, C., Li, R., Huang, T., Wang, Y., Huang, M., Ji, N., Zheng, Y., Chen, X., Shi, L., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01875-5 · Cited by 303
Cuadrado, A., Cazalla, E., Bach, A., Bathish, B., Naidu, S. D., DeNicola, G. M., Dinkova-Kostova, A. T., Fernández-Ginés, R., Grochot-Przeczek, A., Hayes, J. D., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103569 · Cited by 28
Balsamo, J. A., Penton, K. E., Zhao, Z., Hayes, M. J., Lima, S. M., Irish, J. M., & Bachmann, B. O. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102300 · Cited by 12
Metadata
- Authors
- Sauler, M., Bazan, I. S., & Lee, P. J.
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2019-02-10
- Volume
- 81
- Issue
- 1
- Pages
- 375-402
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2902352533
- Cited by
- 326
- References
- 194
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sauler, M., Bazan, I. S., & Lee, P. J. (2019). Cell Death in the Lung: The Apoptosis–Necroptosis Axis. Annual Review of Physiology. https://doi.org/10.1146/annurev-physiol-020518-114320
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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