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Endocrine Effects of Circadian Disruption
Open accessAbstract
Disruption of circadian rhythms, provoked by artificial lighting at night, inconsistent sleep-wake schedules, and transmeridian air travel, is increasingly prevalent in modern society. Desynchrony of biological rhythms from environmental light cycles has dramatic consequences for human health. In particular, disrupting homeostatic oscillations in endocrine tissues and the hormones that these tissues regulate can have cascading effects on physiology and behavior. Accumulating evidence suggests that chronic disruption of circadian organization of endocrine function may lead to metabolic, reproductive, sleep, and mood disorders. This review discusses circadian control of endocrine systems and the consequences of distorting rhythmicity of these systems.
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“The resulting misalignment between the sleep-awake, fasting-feeding cycles, and the light-dark cycle subsequently disrupts the natural oscillations of physiologic processes such as glucose, lipid metabolism, and blood pressure, eventually manifesting itself as heightened risk of developing type 2 diabetes and cardiovascular disease (1–4).”
From Chronotype: Implications for Epidemiologic Studies on Chrono-Nutrition and Cardiometabolic Health (2019) · cites this paper as [3]
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Cites
Antiinflammatory Action of Glucocorticoids — New Mechanisms for Old Drugs
Rhen, T., & Cidlowski, J. A. (2005) · New England Journal of Medicine · doi:10.1056/nejmra050541 · Cited by 3,149
Social Jetlag: Misalignment of Biological and Social Time
Wittmann, M., Dinich, J., Merrow, M., & Roenneberg, T. (2006) · Chronobiology International · doi:10.1080/07420520500545979 · Cited by 2,625
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485
Damiola, F., Le Minh, N., Preitner, N., Kornmann, B., Fleury-Olela, F., & Schibler, U. (2000) · Genes & Development · doi:10.1101/gad.183500 · Cited by 2,394
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351
Yoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135
Stephan, F. K., & Zucker, I. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.6.1583 · Cited by 2,039
Resetting central and peripheral circadian oscillators in transgenic rats
Yamazaki, S., Numano, R., Abe, M., Hida, A., Takahashi, R.-I., Ueda, M., Block, G. D., Sakaki, Y., Menaker, M., & Tei, H. (2000) · Science · doi:10.1126/science.288.5466.682 · Cited by 1,907
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859
Research works printed but not linked: 7
- Halberg F, 1970, Bull. Natl. Speleol. Soc., 32, 89
- McMenamin TM, 2007, Mon. Labor Rev., 130, 3
- 10.1210/en.142.6.2677 · DOI
- Rosenthal NE, 1986, J. Neural Transm. Suppl., 21, 257
- Nguyen J, 2010, Nat. Sci. Sleep, 2, 9
- Rosenthal NE, 1990, Sleep, 13, 354
- Fairbrother K, 2014, Vasc. Health Risk Manag., 10, 691
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Walker, M. L. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780190072865.003.0021
Walker, M. L. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780190072865.003.0019
Walker, M. L. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780190072865.003.0013
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Walker, M. L. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780190072865.003.0009
Walker, M. L. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780190072865.003.0003
Walker, M. L. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780190072865.003.0011
Walker, M. L. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780190072865.003.0017
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Liu, J. A. (2022) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.11606
Zhao, X., Cai, Q., Dong, L., Zhang, X., Wang, C., Wang, S., Liu, L., & Hu, A. (2023) · Sleep And Breathing · doi:10.1007/s11325-023-02791-7
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Delezie, J., & Lamia, K. A. (2024) · Royal Society of Chemistry eBooks · doi:10.1039/bk9781839167553-00345
Walker, M. L. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780190072865.002.0007
Walker, M. L. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780190072865.002.0004
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Labala, R. K., Khan, Z. A., Mondal, G., Hazra, S., Banerjee, B., Dan, A., & Chattoraj, A. (2025) · Biological Rhythm Research · doi:10.1080/09291016.2025.2464687
Nelson, R. J. (2025) · doi:10.1093/9780197639979.003.0002
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Pham, K., Coutts, V. M., Hoffman, A. J., & Wada, H. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.09.656008
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Yin, T.-C., Tsai, M.-L., Liao, S.-H., & Wu, W. (2025) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2025.11.008
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Rawcliffe, A. J., Coombs, C. V., Docherty, A., O’Leary, T. J., & Greeves, J. P. (2026) · SLEEP Advances · doi:10.1093/sleepadvances/zpag073
Gao, Y., Shi, Y., Ye, C., Wang, P., Huang, X., Lai, Y., Qu, F., Cheng, Y., You, D., & Li, Y. X. (2026) · Environment International · doi:10.1016/j.envint.2026.110407
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Metadata
- Authors
- Bedrosian, T. A., Fonken, L. K., & Nelson, R. J.
- Affiliations
- Salk Institute for Biological Studies (US)
- University of Colorado Boulder (US)
- The Ohio State University (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2016-02-10
- Volume
- 78
- Issue
- 1
- Pages
- 109-131
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2137252045
- Cited by
- 170
- References
- 187
- Citations by year
- 2026: 7 · 2025: 16 · 2024: 14 · 2023: 16 · 2022: 30 · 2021: 21 · 2020: 16 · 2019: 10 · 2018: 19 · 2017: 11 · 2016: 8
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Keywords
- circadian rhythm disruption, endocrine system, artificial light at night, transmeridian travel, metabolic disorders, reproductive disorders, sleep disorders, mood disorders, biological rhythms
- MeSH terms
- Animals, Circadian Rhythm, Endocrine System, Humans, Lighting, Sleep
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