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Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms
Abstract
Bone remodeling is essential for the repair and replacement of damaged and old bone. The major principle underlying this process is that osteoclast-mediated resorption of a quantum of bone is followed by osteoblast precursor recruitment; these cells differentiate to matrix-producing osteoblasts, which form new bone to replace what was resorbed. Evidence from osteopetrotic syndromes indicate that osteoclasts not only resorb bone, but also provide signals to promote bone formation. Osteoclasts act upon osteoblast lineage cells throughout their differentiation by facilitating growth factor release from resorbed matrix, producing secreted proteins and microvesicles, and expressing membrane-bound factors. These multiple mechanisms mediate the coupling of bone formation to resorption in remodeling. Additional interactions of osteoclasts with osteoblast lineage cells, including interactions with canopy and reversal cells, are required to achieve coordination between bone formation and resorption during bone remodeling.
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“The overall fate of osteoclasts (i.e., recruitment, differentiation, fusion and apoptosis, see below), is tightly controlled by the process coordinating bone remodeling, in which osteoclasts are also providers of multiple coupling signals196 for osteoblast formation.”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [196]
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Cites
Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J.-Y., Hodsman, A. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441904 · Cited by 4,602
Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166
Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., & Martin, T. J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0367 · Cited by 2,345
Self-citationClassification, Functions, and Clinical Relevance of Extracellular Vesicles
van der Pol, E., Böing, A. N., Harrison, P., Sturk, A., & Nieuwland, R. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005983 · Cited by 1,806
c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
Grigoriadis, A. E., Wang, Z., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., & Wagner, E. F. (1994) · Science · doi:10.1126/science.7939685 · Cited by 1,264
Black, D. M., Greenspan, S. L., Ensrud, K. E., Palermo, L., McGowan, J., Lang, T., Garnero, P., Bouxsein, M., Bilezikian, J. P., & Rosen, C. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa031975 · Cited by 1,168
TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation
Tang, Y., Wu, X., Lei, W., Pang, L., Wan, C., Shi, Z., Zhao, L., Nagy, T. R., Peng, X., Hu, J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1979 · Cited by 1,165
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis
Xie, H., Cui, Z., Wang, L., Xia, Z., Hu, Y., Xian, L., Li, C., Xie, L., Crane, J., Wan, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3668 · Cited by 951
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Pappu, R., Schwab, S. R., Cornelissen, I., Pereira, J. P., Regard, J. B., Xu, Y., Camerer, E., Zheng, Y., Huang, Y., Cyster, J. G., et al. (2007) · Science · doi:10.1126/science.1139221 · Cited by 904
Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.
Tamura, T., Udagawa, N., Takahashi, N., Miyaura, C., Tanaka, S., Yamada, Y., Koishihara, Y., Ohsugi, Y., Kumaki, K., & Taga, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11924 · Cited by 828
Research works printed but not linked: 5
- Frost HM., 1964, Bone Biodynamics, 315
- Parfitt A., 1983, Histomorphometry, 142
- Baron R., 1977, Bone Remodelling, 179
- Rauch F., 2012, J. Musculoskelet. Neuronal Interact., 12, 1
- Lotinun S, 2013, J. Clin. Investig., 123, 666
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Ye, Q., Xu, H., Liu, S., Li, Z., Zhou, J., Ding, F., Zhang, X., Wang, Y., Jin, Y. J., & Wang, Q. (2022) · Journal of Periodontology · doi:10.1002/jper.21-0657 · Cited by 85
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Chu, A., Zirngibl, R. A., & Manolson, M. F. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136934 · Cited by 34
Yang, X., Liang, J., Wang, Z., Su, Y., Zhan, Y., Wu, Z., Li, J., Li, X., Chen, R., Zhao, J., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.664697 · Cited by 33
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Lau, P., Vico, L., & Rittweger, J. (2022) · Biomedicines · doi:10.3390/biomedicines10020342 · Cited by 32
Liu, H., Jiang, H., Liu, X., & Wang, X. (2023) · Exploration · doi:10.1002/exp.20230033 · Cited by 31
Yin, S., Lin, S., Xu, J., Yang, G., Chen, H., & Jiang, X. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02085-w · Cited by 30
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Xie, C., Wu, T., Wang, Y., Capon, R. J., Xu, R., & Yang, X. (2024) · Organic Letters · doi:10.1021/acs.orglett.4c01065 · Cited by 29
Hu, H., Zhang, Z.-Y., Luo, Z. X., Ti, H., Wu, J., Nie, H., Yuan, Z., Wu, X. L., Zhang, K.-Y., Shi, S., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02633-3 · Cited by 40
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Qin, Y., Hu, C., Jin, J., Chao, Y., Wang, D., Xia, F., Ruan, C., Jiang, C., Guan, M., & Zou, C. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136504 · Cited by 29
Chen, Y., Gan, W., Cheng, Z., Zhang, A., Shi, P., & Zhang, Y. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100920 · Cited by 27
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Campbell, M. J., Bustamante-Gomez, C., Fu, Q., Beenken, K. E., Reyes-Pardo, H., Smeltzer, M. S., & O’Brien, C. A. (2024) · Bone · doi:10.1016/j.bone.2024.117181 · Cited by 28
Cai, W., Huo, Y., Liu, Y., Su, Y., Guo, H., Wang, L., Li, B., & Liang, T. (2025) · EngMedicine · doi:10.1016/j.engmed.2025.100057 · Cited by 31
Tian, Y., Shao, Q., Tang, Y., Li, X., Qi, X., Jiang, R., Liang, Y., & Kang, F. (2020) · Oral Diseases · doi:10.1111/odi.13745 · Cited by 27
Bashiruddin, N. K., Hayashi, M., Nagano, M., Wu, Y. Z., Matsunaga, Y., Takagi, J., Nakashima, T., & Suga, H. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2012266117 · Cited by 27
Li, D., Jiang, Y., He, P., Li, Y., Wu, Y., Lei, W., Liu, N., de Bruijn, J. D., Zhang, H., Zhang, H., et al. (2023) · Advanced Science · doi:10.1002/advs.202207224 · Cited by 27
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Metadata
- Authors
- Sims, N. A., & Martin, T. J.
- Affiliations
- The University of Melbourne (AU)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2020-02-10
- Volume
- 82
- Issue
- 1
- Pages
- 507-529
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2977240403
- Cited by
- 286
- References
- 148
- Citations by year
- 2026: 48 · 2025: 37 · 2024: 47 · 2023: 37 · 2022: 49 · 2021: 47 · 2020: 19
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteoclasts, osteoblast lineage cells, bone remodeling, bone resorption, bone formation, microvesicles, growth factor release, osteoclastogenesis
- MeSH terms
- Animals, Cell Differentiation, Humans, Osteoblasts, Osteoclasts, Osteogenesis, Signal Transduction, Bone Remodeling, Cell Lineage, Exosomes
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