Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis

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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

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Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

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Classification, Functions, and Clinical Relevance of Extracellular Vesicles

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c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

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The Effects of Parathyroid Hormone and Alendronate Alone or in Combination in Postmenopausal Osteoporosis

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TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

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PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

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Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate

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Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

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A Critical Role of the Bone Marrow Envelope in Human Bone Remodeling

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Bone marrow neutrophil progenitors suppress osteoclast formation in murine cortical and trabecular bone

Isojima, T., Crimeen‐Irwin, B., McGregor, N. E., Chai, R. C. C., Poulton, I. J., Walker, E. C., Dutt, M., Parker, B. L., & Sims, N. A. (2025) · Blood · doi:10.1182/blood.2025028310 · Cited by 19

Bone Geometry Is Altered by Follistatin‐Induced Muscle Growth in Young Adult Male Mice

Chan, A. S. M., McGregor, N. E., Poulton, I. J., Hardee, J. P., Cho, H., Martin, T. J., Gregorevic, P., Sims, N. A., & Lynch, G. S. (2021) · JBMR Plus · doi:10.1002/jbm4.10477 · Cited by 19

WHIM Syndrome-linked CXCR4 mutations drive osteoporosis

Anginot, A., Nguyen, J., Nader, Z. A., Rondeau, V., Bonaud, A., Kalogeraki, M., Boutin, A., Lemos, J. P., Bisio, V., Koenen, J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37791-4 · Cited by 20

Exosomal Osteoclast-Derived miRNA in Rheumatoid Arthritis: From Their Pathogenesis in Bone Erosion to New Therapeutic Approaches

Pascual-García, S., Martínez-Peinado, P., Pujalte-Satorre, C., Navarro‐Sempere, A., Esteve-Girbés, J., López-Jaén, A. B., Javaloyes-Antón, J., Cobo, R., Navarro-Blasco, F. J., & Sempere-Ortells, J. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031506 · Cited by 19

Rectifying the Crosstalk between the Skeletal and Immune Systems Improves Osteoporosis Treatment by Core–Shell Nanocapsules

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Posttranslational Modification in Bone Homeostasis and Osteoporosis

Lin, Y., Jiang, S., Yao, Y., Li, H., Jin, H., Yang, G., Ji, B., & Li, Y. (2025) · MedComm · doi:10.1002/mco2.70159 · Cited by 18

Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro

Humbert, P., Brennan, M. Á., Lima, J. D., Brion, R., Adrait, A., Charrier, C., Brulin, B., Trichet, V., Couté, Y., Blanchard, F., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-91258-4 · Cited by 18

Stimulation of Osteoclast Formation by Oncostatin M and the Role of WNT16 as a Negative Feedback Regulator

de Souza, P. C., Henning, P., & Lerner, U. H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063287 · Cited by 17

Osteoclast-derived coupling factors: origins and state-of-play Louis V Avioli lecture, ASBMR 2023

Sims, N. A. (2024) · Journal of Bone and Mineral Research · doi:10.1093/jbmr/zjae110 · Cited by 19

Aberrant paracrine signalling for bone remodelling underlies the mutant histone-driven giant cell tumour of bone

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Energetic Calcium Phosphate Nanominerals for Osteoporosis Treatment

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Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics

Guo, W., Yang, Z., Liu, F., Song, J., Yang, W., Li, Y., Hu, W., & Wang, K. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102066 · Cited by 18

Longitudinal alterations in bone morphometry, mechanical integrity and composition in Type-2 diabetes in a Zucker diabetic fatty (ZDF) rat

Monahan, G. E., Schiavi, J., Britton, M., & Vaughan, T. J. (2023) · Bone · doi:10.1016/j.bone.2023.116672 · Cited by 20

Biphasic Functions of Sodium Fluoride (NaF) in Soft and in Hard Periodontal Tissues

Wang, X., Tewari, N., Sato, F., Tanimoto, K., Thangavelu, L. P., Makishima, M., & BHAWAL, U. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020962 · Cited by 17

The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous drug resistant disease

Bishop, R. T., Miller, A. K., Froid, M., Nerlakanti, N., Li, T., Frieling, J. S., Nasr, M. M., Nyman, K. J., Sudalagunta, P. R., Canevarolo, R. R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-46594-0 · Cited by 16

Epoxymicheliolide inhibits osteoclastogenesis and resists OVX-induced osteoporosis by suppressing ERK1/2 and NFATc1 signaling

Long, F., Chen, R., Su, Y., Liang, J., Xian, Y., Yang, F., Lian, H., Xu, J., Zhao, J., & Liu, Q. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108632 · Cited by 16

Bone fragility: conceptual framework, therapeutic implications, and COVID-19-related issues

Iolascon, G., Paoletta, M., Liguori, S., Gimigliano, F., & Moretti, A. (2022) · Therapeutic Advances in Musculoskeletal Disease · doi:10.1177/1759720x221133429 · Cited by 18

Silk sericin-based functional food for osteoporosis prevention and therapy

Jin, X., Che, X., Lee, D.-K., Cui, Y., Choi, P.-R., Kim, H., Lee, J. H., Kweon, H., Kim, S., & Choi, J. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106148 · Cited by 18

CSF1R as a Therapeutic Target in Bone Diseases: Obvious but Not so Simple

Hume, D. A., Batoon, L., Sehgal, A., Keshvari, S., & Irvine, K. M. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00757-4 · Cited by 17

The Impact of Angiotensin Converting Enzyme-2 (ACE-2) on Bone Remodeling Marker Osteoprotegerin (OPG) in Post-COVID-19 Iraqi Patients

AL-Azzawi, I. S., & Mohammed, N. S. (2022) · Cureus · doi:10.7759/cureus.29926 · Cited by 15

Lycium barbarum polysaccharide‐glycoprotein promotes osteogenesis in hPDLSCs via ERK activation

Lai, S., Liu, C., Liu, C., Fan, L., Li, X., Yang, Y., Zhu, Y., Deng, L., Li, X., & Mu, Y. (2022) · Oral Diseases · doi:10.1111/odi.14409 · Cited by 15

Bone Remodeling and Modeling: Cellular Targets for Antiresorptive and Anabolic Treatments, Including Approaches Through the Parathyroid Hormone (PTH)/PTH-Related Protein Pathway

Martin, T. J., & Seeman, E. (2023) · Neurospine · doi:10.14245/ns.2346966.483 · Cited by 17

Comparison of Synthetic vs. Biogenic Polymeric Process-Directing Agents for Intrafibrillar Mineralization of Collagen

Saxena, N., Mizels, J., Cremer, M. A., Guarnizo, V., Rodriguez, D. E., & Gower, L. B. (2022) · Polymers · doi:10.3390/polym14040775 · Cited by 15

Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice

Koide, M., Yamashita, T., Nakamura, K., Yasuda, H., Udagawa, N., & Kobayashi, Y. (2022) · Bone · doi:10.1016/j.bone.2022.116401 · Cited by 15

Sclerostin's role in bone–muscle crosstalk and osteoporosis pathogenesis

Shahid, H., Morya, V. K., & Noh, K.-C. (2025) · Osteoporosis and Sarcopenia · doi:10.1016/j.afos.2025.06.004 · Cited by 17

Type H vessel/platelet‐derived growth factor receptor β + perivascular cell disintegration is involved in vascular injury and bone loss in radiation‐induced bone damage

Li, J., Chen, X., Ren, L., Chen, X., Wu, T., Wang, Y., Ren, X., Cheng, B., & Xia, J. (2023) · Cell Proliferation · doi:10.1111/cpr.13406 · Cited by 15

Impact of Different Cell Types on the Osteogenic Differentiation Process of Mesenchymal Stem Cells

Wang, Z., Ren, L., Li, Z., Qingyuan, Q., Wang, H., Huang, X., & Ma, D. (2025) · Stem Cells International · doi:10.1155/sci/5551222 · Cited by 17

Suppressors of cytokine signaling (SOCS) proteins in inflammatory bone disorders

Santos, M. R. G., Queiroz‐Junior, C. M., Madeira, M. F. M., & Machado, F. S. (2020) · Bone · doi:10.1016/j.bone.2020.115538 · Cited by 15

Geranylgeraniol Restores Zoledronic Acid-Induced Efferocytosis Inhibition in Bisphosphonate-Related Osteonecrosis of the Jaw

Chen, X., Zhu, W., Xu, R., Shen, X., Fu, Y., Cheng, J., Liu, L., & Jiang, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.770899 · Cited by 16

Loureirin B downregulates osteoclast differentiation of bone marrow macrophages by targeting the MAPK signaling pathway

Zhang, J., Mo, L., Huang, H., Xu, J., Fan, Y., Li, W., Wang, H., Zhou, C., Fang, H., He, W., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-18287-5 · Cited by 14

PTPRJ promotes osteoclast maturation and activity by inhibiting Cbl‐mediated ubiquitination of NFATc1 in late osteoclastogenesis

Shalev, M., Arman, E., Stein, M., Cohen‐Sharir, Y., Brumfeld, V., Kapishnikov, S., Royal, I., Tuckermann, J. P., & Elson, A. (2021) · FEBS Journal · doi:10.1111/febs.15778 · Cited by 13

Patient‐Specific Bioimplants and Reconstruction Plates for Mandibular Defects: Production Workflow and In Vivo Large Animal Model Study

Dienel, K., Abu-Shahba, A. G., Kornilov, R., Björkstrand, R., van Bochove, B., Snäll, J., Wilkman, T. S. E., Mesimäki, K., Meller, A., Lindén, J., et al. (2022) · Macromolecular Bioscience · doi:10.1002/mabi.202100398 · Cited by 16

Osteoclasts at Bone Remodeling: Order from Order

Takito, J., & Nonaka, N. (2023) · Results and problems in cell differentiation · doi:10.1007/978-3-031-37936-9_12 · Cited by 14

Does Aging Activate T-cells to Reduce Bone Mass and Quality?

Aurora, R., & Novack, D. V. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00745-8 · Cited by 13

Toll-like receptor-2 induced inflammation causes local bone formation and activates canonical Wnt signaling

Henning, P., Kassem, A., Westerlund, A., Lundberg, P., Engdahl, C., Lionikaite, V., Wikström, P., Wu, J., Li, L., Lindholm, C., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1383113 · Cited by 12

Research progress of gene therapy combined with tissue engineering to promote bone regeneration

Chu, X., Xiong, Y., Lu, L. F., Wang, Y., Wang, J., Zeng, R., Hu, L., Yan, C., Zhao, Z., Lin, S., et al. (2024) · APL Bioengineering · doi:10.1063/5.0200551 · Cited by 12

The impact of exosomes on bone health: A focus on osteoporosis

Mehrvar, A., Akbari, M., Khosroshahi, E. M., Nekavand, M., Mokhtari, K., Baniasadi, M., Aghababaian, M., Karimi, M., Amiri, S., Moazen, A., et al. (2024) · Pathology - Research and Practice · doi:10.1016/j.prp.2024.155618 · Cited by 13

Roles of Slit Ligands and Their Roundabout (Robo) Family of Receptors in Bone Remodeling

Niimi, T. (2020) · Advances in experimental medicine and biology · doi:10.1007/5584_2020_586 · Cited by 11

Exosomes: A new option for osteoporosis treatment

Huang, G., Zhao, Q., Li, W., Jiao, J., Zhao, X., Feng, D., & Tang, W. (2022) · Medicine · doi:10.1097/md.0000000000032402 · Cited by 12

Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair

Wan, T., Zhang, M., Jiang, H.-R., Zhang, Y.-C., Zhang, X., Wang, Y., & Zhang, P. (2023) · Nanomaterials · doi:10.3390/nano13091449 · Cited by 12

A Practical Procedure for the In Vitro Generation of Human Osteoclasts and Their Characterization

Husch, J. F. A., Stessuk, T., den Breejen, C., van den Boom, M., Leeuwenburgh, S. C. G., & van den Beucken, J. J. J. P. (2021) · Tissue Engineering Part C Methods · doi:10.1089/ten.tec.2021.0122 · Cited by 12

A Multifunctional Therapeutic Strategy Using P7C3 as A Countermeasure Against Bone Loss and Fragility in An Ovariectomized Rat Model of Postmenopausal Osteoporosis

Wei, F., Hughes, M., Omer, M., Ngo, C., Pugazhendhi, A. S., Kolanthai, E., Aceto, M., Ghattas, Y. S., Razavi, M., Kean, T. J., et al. (2024) · Advanced Science · doi:10.1002/advs.202308698 · Cited by 11

Interplay Between Skeletal and Hematopoietic Cells in the Bone Marrow Microenvironment in Homeostasis and Aging

Quarato, E. R., Salama, N., & Calvi, L. M. (2024) · Current Osteoporosis Reports · doi:10.1007/s11914-024-00874-2 · Cited by 11

Osteostaticytes: A novel osteoclast subset couples bone resorption and bone formation

Wei, Z.-Y., Zhou, J., Shen, J., Sun, D., Gao, T., Liu, Q., Wu, H., Wang, X. H., Wang, S., Xiao, S., et al. (2024) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2024.06.010 · Cited by 10

Advances in mechanism and management of bone homeostasis in osteonecrosis: a review article from basic to clinical applications

Xiang, X.-N., He, H., & He, C. (2024) · International Journal of Surgery · doi:10.1097/js9.0000000000002094 · Cited by 12

Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration

Shariati, K., Bedar, M., Huang, K. X., Moghadam, S., Mirzaie, S., LaGuardia, J. S., Chen, W., Kang, Y., Ren, X., & Lee, J. C. (2024) · Advanced Therapeutics · doi:10.1002/adtp.202400296 · Cited by 15

Mechanosensor YAP mediates bone remodeling via NF-κB p65 induced osteoclastogenesis during orthodontic tooth movement

Deng, J., Zhang, Y.-N., Bai, R., Yu, T., Zhao, Y., Liu, H., Zhang, Y.-F., Xu, T., & Han, B. (2025) · Progress in Orthodontics · doi:10.1186/s40510-024-00548-w · Cited by 10

Bone-on-a-chip recapitulates dynamic bone remodeling

Zhang, Y., Zhao, Y., Sun, Z., An, C., Zheng, G., Shen, Y., Zhu, X., Ren, C., Zhang, L., Chen, T., et al. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.10.039 · Cited by 11

Single-cell transcriptomic analysis identifies a highly replicating Cd168+ skeletal stem/progenitor cell population in mouse long bones

Hao, R.-C., Li, Z., Wang, F., Tang, J., Li, P., Yin, B.-F., Li, X., Han, M.-Y., Mao, N., Liu, B., et al. (2023) · Journal of genetics and genomics/Journal of Genetics and Genomics · doi:10.1016/j.jgg.2023.04.004 · Cited by 10

Parental Origin of Gsα Inactivation Differentially Affects Bone Remodeling in a Mouse Model of Albright Hereditary Osteodystrophy

McMullan, P., Maye, P. F., Yang, Q., Rowe, D. W., & Germain‐Lee, E. L. (2021) · JBMR Plus · doi:10.1002/jbm4.10570 · Cited by 9

Biomimetic polydopamine-laced hydroxyapatite collagen material orients osteoclast behavior to an anti-resorptive pattern without compromising osteoclasts’ coupling to osteoblasts

Wang, L., Wu, T., Hu, X., Liu, J., Wu, D., Miguez, P. A., Wright, J. T., Zhang, S., Chi, J., Tseng, H. C., et al. (2021) · Biomaterials Science · doi:10.1039/d1bm01119g · Cited by 11

RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway

Wang, H., Yuan, X., Han, J., Wu, Z., Ma, Z., Shi, F., Luo, Z., Chen, Z., Guo, C., Yuan, G., et al. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.03.002 · Cited by 9

Combined physical and pharmacological anabolic osteoporosis therapies increase bone response and mechanoregulation in female mice

Schulte, F. A., Marques, F. C., Griesbach, J. K., Weigt, C., von Salis‐Soglio, M., Lambers, F. M., Kreutz, C., Kneissel, M., Richards, P. J., Kuhn, G. A., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-70309-2 · Cited by 10

NLRC5 modulates bone metabolism and plays a role in periodontitis

Wang, W., Liu, W., Liu, J., Lv, P., Wang, Y., & Ouyang, X. (2022) · Journal of Periodontal Research · doi:10.1111/jre.13027 · Cited by 9

Is the Use of Bisphosphonates Putting Horses at Risk? An Osteoclast Perspective

Vergara‐Hernandez, F. B., Nielsen, B. D., & Colbath, A. C. (2022) · Animals · doi:10.3390/ani12131722 · Cited by 10

Jiangu formula: A novel osteoclast-osteoblast coupling agent for effective osteoporosis treatment

Xu, H., Lu, X., Li, M., Huang, X., Yao, N., Gan, H., Huang, X., Zhao, X., Hu, Z., Zhao, X., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155501 · Cited by 10

Onc201 reduces osteoclastogenesis and prevents ovariectomy-induced bone loss via inhibiting RANKL-induced NFATc1 activation and the integrin signaling pathway

Wu, L., Liang, J., Li, J., Xu, Y., Chen, J., Su, Y., Xian, Y., Wei, J., Xu, J., Zhao, J., et al. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174908 · Cited by 9

Probucol suppresses osteoclastogenesis via activating Nrf2 signaling and ameliorates ovariectomy-induced bone loss

Guo, J., Ren, R., Guo, Z., Sun, K., He, J., Shao, J., & Wang, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109820 · Cited by 9

The Impact of Culture Variables on a 3D Human In Vitro Bone Remodeling Model: A Design of Experiments Approach

de Wildt, B. W. M., Cuypers, L. A. B., Cramer, E. E. A., Wentzel, A. S., Ito, K., & Hofmann, S. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301205 · Cited by 9

Deletion of phospholipase D1 decreases bone mass and increases fat mass via modulation of Runx2, β-catenin-osteoprotegerin, PPAR-γ and C/EBPα signaling axis

Kang, D. W., Hwang, W. C., Noh, Y. N., Che, X., Lee, S.-H., Jang, Y., Choi, K., Choi, J., & Min, D. S. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166084 · Cited by 7

Emerging Strategies for Optimizing Cell‐Derived Decellularized Extracellular Matrix Scaffolds in Tissue Engineering

Chen, H., Zhang, S., & Fu, Y. (2024) · Advanced Engineering Materials · doi:10.1002/adem.202302148 · Cited by 8

Contribution of Osteoblast and Osteoclast Supernatants to Bone Formation: Determination Using a Novel Microfluidic Chip

Park, S. H., An, H., Kim, H., Song, I., & Lee, S. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126605 · Cited by 9

Abaloparatide Maintains Normal Rat Blood Calcium Level in Part Via 1,25-Dihydroxyvitamin D/osteocalcin Signaling Pathway

Yang, Y., Tseng, W., & Wang, B. (2023) · Endocrinology · doi:10.1210/endocr/bqad117 · Cited by 7

Osteoprotegerin secretion and its inhibition by RANKL in osteoblastic cells visualized using bioluminescence imaging

Ninomiya, H., Fukuda, S., Nishida‐Fukuda, H., Shibata, Y., Sato, T., Nakamichi, Y., Nakamura, M., Udagawa, N., Miyazawa, K., & Suzuki, T. (2024) · Bone · doi:10.1016/j.bone.2024.117319 · Cited by 7

Potent suppression of bone remodeling by denosumab does not blunt the anabolic response to romosozumab in mice

Bustamante-Gomez, C., Fu, Q., Goellner, J. J., Thostenson, J. D., Reyes-Pardo, H., & O’Brien, C. A. (2025) · Bone · doi:10.1016/j.bone.2025.117567 · Cited by 7

Osteocyte dysregulation in periodontitis: Pathological mechanisms and therapeutic potential

Si, L., Tian, X., Tian, L., & Yang, K. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112062 · Cited by 8

Redox-regulated bone loss in spaceflight and terrestrial models: Molecular mechanisms and therapeutic strategies

Pintus, G., Akram, M. A., Giordo, R., Caggiari, G., & Majdalawieh, A. F. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.11.048 · Cited by 9

Quercetin in metabolic diseases: mechanisms, therapeutics, and multidimensional frontiers

Song, Q., Liu, L., Yang, Q., Pan, M., & Zhang, Y. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1800322 · Cited by 8

PDGF-BB improves cortical bone quality through restoring the osteogenic microenvironment in the steroid-associated osteonecrosis of rabbits

Cao, H., Shi, K., Long, J., Liu, Y., Meng, X., Huang, C., Hao, J., Li, L., Zhao, Y., Ye, T., et al. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.03.010 · Cited by 8

Extracellular Vesicles in Bone Tumors: How to Seed in the Surroundings Molecular Information for Malignant Transformation and Progression

Cappariello, A., & Rucci, N. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.722922 · Cited by 7

The truth about 17-beta estradiol: menopause beyond “old wives’ tales”

Nelson, L. M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1229804 · Cited by 7

Receptor activator of nuclear factor-kappa B is enriched in CD9-positive extracellular vesicles released by osteoclasts

Ruan, S., Rody, W. J., Patel, S. S., Hammadi, L. I., Martin, M. L., de Faria, L. P., Daaboul, G. G., Anderson, L., He, M., & Holliday, L. S. (2023) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2023.38 · Cited by 7

Mechanical Load, Sex Hormones, and Bone Modeling

Windahl, S. H., & Lerner, U. H. (2021) · Wiley eBooks · doi:10.1002/9781119608912.ch7 · Cited by 7

Mechanotransduction in osteoclasts: Novel strategies of bone repairs

Xu, J. (2023) · Mechanobiology in Medicine · doi:10.1016/j.mbm.2023.100008 · Cited by 6

Optineurin regulates osteoblast function in an age-dependent fashion in a mouse model of Paget's disease of bone

Hu, X., Foster, B. L., Zhao, B., Tseng, H. C., Wu, Y.-C., & Ko, C. (2023) · Bone · doi:10.1016/j.bone.2023.116929 · Cited by 6

Aspects of intercellular communication in bone and implications in therapy

Martin, T. J. (2021) · Bone · doi:10.1016/j.bone.2021.116148 · Cited by 6

Plasma Membrane Receptors Involved in the Binding and Response of Osteoclasts to Noncellular Components of the Bone

Karanth, D., Martin, M. L., & Holliday, L. S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221810097 · Cited by 7

Effect of Diabetes Mellitus and Anti-Diabetic Drugs on Bone Health-A Review

Deeba, F., Younis, S., Qureshi, N., Mustafa, T., Iqbal, N., & Hussain, S. (2021) · Journal of Bioresource Management · doi:10.35691/jbm.1202.0187 · Cited by 6

Bibliometric insights from publications on subchondral bone research in osteoarthritis

Wen, P., Liu, R., Wang, J., Wang, Y., Song, W., & Zhang, Y. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1095868 · Cited by 7

Cathepsin K inhibitors promote osteoclast-osteoblast communication and engagement of osteogenesis

Panwar, P., Olesen, J. B., Delaissé, J., Søe, K., & Brömme, D. (2025) · JBMR Plus · doi:10.1093/jbmrpl/ziaf079 · Cited by 5

Bone microenvironments-regulated biomaterials boost osteonecrosis therapy

Dong, H., Zhu, T., Sun, Y., Yang, J., Liu, G., Wang, G., & Ding, J. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123921 · Cited by 5

Three-dimensional quantitative tissue clearing reveals differences in osteovascular niche of aged and young human mesenchymal stromal cells

Chu, N. T. L., Dregval, O. A., Chang, Y.-W., Kriukov, E., Tian, X., Liu, X., Trompet, D., Zhang, M. S., Li, L., Li, Z., et al. (2026) · Nature Biomedical Engineering · doi:10.1038/s41551-026-01645-3 · Cited by 6

Phlpp1 Expression in Osteoblasts Plays a Modest Role in Bone Homeostasis

Karkache, I. Y., Molstad, D. H. H., Vu, E. K., Jensen, E. D., & Bradley, E. W. (2023) · JBMR Plus · doi:10.1002/jbm4.10806 · Cited by 5

Cortactin controls bone homeostasis through regulating the differentiation of osteoblasts and osteoclasts

Yang, X., Chen, M., Wang, S., Hu, X., Zhou, J., Yuan, H., Zhu, E., & Wang, B. (2024) · Stem Cells · doi:10.1093/stmcls/sxae031 · Cited by 5

Metabolic shifts in ratio of ucOcn to cOcn toward bone resorption contribute to age-dependent bone loss in male mice

Bernhard, M., Okorie, O., Tseng, W., Chen, M., Danon, J. N., Cui, M., Lashbrooks, E., Yang, Y., & Wang, B. (2024) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00294.2024 · Cited by 5

Research progress on the role of extracellular vesicles derived from aging cells in osteoporosis

Chen, H., Huang, G., Mao, W., He, P., Hou, G., Zhang, W., Liu, Z., Li, A., & Qin, S. (2023) · Bioscience Reports · doi:10.1042/bsr20221775 · Cited by 5

The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant diseasePreprint

Bishop, R. T., Miller, A., Froid, M., Nerlakanti, N., Li, T., Frieling, J. S., Nasr, M., Nyman, K. J., Sudalagunta, P. R., Canevarolo, R. R., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.13.516335 · Cited by 5

Local and Systemic Regulation of Mineralization: Role of Coupling Factors, Pyrophosphate, Polyphosphates, Vitamin D, Fetuin, Matrix Gla Protein, and Osteopontin

Shapiro, I. M., & Landis, W. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-34304-9_9 · Cited by 5

Early cellular events of osteomucosal healing in the tooth extraction socket

Kim, S., Song, M., Williams, D. W., Du, W., Cho, I., Bae, E., Kim, J., Goswami, A., Shin, K.-H., Park, N., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0328459 · Cited by 5

Multiple applications of metal-organic frameworks (MOFs) in the treatment of orthopedic diseases

Zhao, Z., Wang, C.-X., Liu, A., Bai, N., Jiang, B.-X., Mao, Y., Ying, T., Dong, D.-M., Yi, C., & Li, D.-J. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1448010 · Cited by 3

Metallic ions integrated in tannic acid (TA) as a metal–organic-like complex coating on biodegradable magnesium for enhanced corrosion control and biocompatibility

Wang, J., Dou, Z., & Huang, N. (2024) · Journal of Materials Science · doi:10.1007/s10853-024-10256-9 · Cited by 4

d -limonene suppresses RANKL-induced osteoclast differentiation and promotes osteoblast activity in vitro

McCallum, L. M. R., & Fox, S. W. (2024) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbae164 · Cited by 3

Neutralization of Receptor activator of nuclear factor-κB ligand reduces fibrosis and promotes osteoblast differentiation in a mouse model of fibrous dysplasia driven by somatic expression of GnasR201H

Ormsby, R. T., Zhang, Y., Hodys, C., Wake, L. A., Perez, S. M., Tsang, K., Yang, Y., & Charles, J. F. (2025) · JBMR Plus · doi:10.1093/jbmrpl/ziaf145 · Cited by 3

Periodontitis as a Model for Inflammatory Uncoupling of Bone Remodeling

de Molon, R. S., Tetradis, S., Vernal, R., Leite, F. R. M., & Dyke, T. E. V. (2026) · Journal of Periodontal Research · doi:10.1111/jre.70148 · Cited by 5

Developing a Bone-Mimicking Microenvironment: Surface Coating Method for Investigating Bone Remodeling in Vitro

Sieberath, A., Eglin, D., Sprecher, C. M., Ferreira, A. M., Gentile, P., Dalgarno, K. W., & Bella, E. D. (2025) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c02330 · Cited by 3

Conditional loss of CaMKK2 in Osterix-positive osteoprogenitors enhances osteoblast function in a sex-divergent manner

Mattingly, B. T., Kambrath, A. V., Ding, X., Thompson, W. R., & Sankar, U. (2024) · Bone · doi:10.1016/j.bone.2024.117113 · Cited by 3

Proteins and peptides responsible for bone remodeling

Barbosa-Nuñez, J. A., Haro-González, J. N., García-Márquez, E., Espinosa‐Andrews, H., Padilla‐Camberos, E., & Herrera-Rodríguez, S. E. (2025) · Differentiation · doi:10.1016/j.diff.2025.100872 · Cited by 3

Mechanically adaptive Mg-Ti composites guided by single-cell insights accelerate load-bearing bone regeneration via dual modulation of osteogenesis and osteoclastogenesis

Zheng, W., Tian, S., Huo, J., Zhang, Q., Wang, D., Liu, Z., Zhao, B., Gao, Y., Zhang, Z., & Wang, Q. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.10.038 · Cited by 2

Osteoclast-Derived Coupling Factors in Bone Remodeling

Henriksen, K., Karsdal, M. A., & Martin, T. J. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9741-7 · Cited by 146

Osteoclast-derived activity in the coupling of bone formation to resorption

Martin, T. J., & Sims, N. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.004 · Cited by 661

Molecular Mechanisms in Coupling of Bone Formation to Resorption

Martin, T. J., Gooi, J. H., & Sims, N. A. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i1.40 · Cited by 167

Coupling of bone formation and resorption

Sims, N. A., & Martin, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00010-5 · Cited by 11

Beyond resorption-driven coupling: a multi-layered framework for osteoclast–osteoblast communication and its therapeutic consequences

Qiu, H., Liu, S., Jiang, Y., Lai, Y., Lin, Q., & Huang, A. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1821292 · Cited by 2