The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms
Abstract
Bone remodeling is essential for the repair and replacement of damaged and old bone. The major principle underlying this process is that osteoclast-mediated resorption of a quantum of bone is followed by osteoblast precursor recruitment; these cells differentiate to matrix-producing osteoblasts, which form new bone to replace what was resorbed. Evidence from osteopetrotic syndromes indicate that osteoclasts not only resorb bone, but also provide signals to promote bone formation. Osteoclasts act upon osteoblast lineage cells throughout their differentiation by facilitating growth factor release from resorbed matrix, producing secreted proteins and microvesicles, and expressing membrane-bound factors. These multiple mechanisms mediate the coupling of bone formation to resorption in remodeling. Additional interactions of osteoclasts with osteoblast lineage cells, including interactions with canopy and reversal cells, are required to achieve coordination between bone formation and resorption during bone remodeling.
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“The overall fate of osteoclasts (i.e., recruitment, differentiation, fusion and apoptosis, see below), is tightly controlled by the process coordinating bone remodeling, in which osteoclasts are also providers of multiple coupling signals196 for osteoblast formation.”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [196]
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Cites
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Cited by
Sorted by citations
Osteoblast-Osteoclast Communication and Bone Homeostasis
Kim, J., Lin, C., Stavre, Z., Greenblatt, M. B., & Shim, J. (2020) · Cells · doi:10.3390/cells9092073 · Cited by 1,266
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482
Noirrit‐Esclassan, E., Valera, M., Trémollières, F., Arnal, J., Lenfant, F., Fontaine, C., & Vinel, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041568 · Cited by 259
Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis
Zhu, X., Chan, Y.-T., Yung, P. S., Tuan, R. S., & Jiang, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.607764 · Cited by 218
Macrophages and Bone Remodeling
Weivoda, M. M., & Bradley, E. W. (2023) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4773 · Cited by 166
Metadata
- Authors
- Sims, N. A., & Martin, T. J.
- Affiliations
- The University of Melbourne (AU)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2020-02-10
- Volume
- 82
- Issue
- 1
- Pages
- 507-529
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- OpenAlex
- W2977240403
- Cited by
- 286
- References
- 148
- Citations by year
- 2026: 48 · 2025: 37 · 2024: 47 · 2023: 37 · 2022: 49 · 2021: 47 · 2020: 19
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Keywords
- osteoclasts, osteoblast lineage cells, bone remodeling, bone resorption, bone formation, microvesicles, growth factor release, osteoclastogenesis
- MeSH terms
- Animals, Cell Differentiation, Humans, Osteoblasts, Osteoclasts, Osteogenesis, Signal Transduction, Bone Remodeling, Cell Lineage, Exosomes
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