Osteoclasts Provide Coupling Signals to Osteoblast Lineage Cells Through Multiple Mechanisms

Effect of Parathyroid Hormone (1-34) on Fractures and Bone Mineral Density in Postmenopausal Women with Osteoporosis

Neer, R. M., Arnaud, C. D., Zanchetta, J. R., Prince, R., Gaich, G. A., Reginster, J.-Y., Hodsman, A. B., Eriksen, E. F., Ish-Shalom, S., Genant, H. K., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejm200105103441904 · Cited by 4,602

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

Suda, T., Takahashi, N., Udagawa, N., Jimi, E., Gillespie, M. T., & Martin, T. J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.3.0367 · Cited by 2,345

Classification, Functions, and Clinical Relevance of Extracellular Vesicles

van der Pol, E., Böing, A. N., Harrison, P., Sturk, A., & Nieuwland, R. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005983 · Cited by 1,806

c-Fos: a Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling

Grigoriadis, A. E., Wang, Z., Cecchini, M. G., Hofstetter, W., Felix, R., Fleisch, H. A., & Wagner, E. F. (1994) · Science · doi:10.1126/science.7939685 · Cited by 1,264

The Effects of Parathyroid Hormone and Alendronate Alone or in Combination in Postmenopausal Osteoporosis

Black, D. M., Greenspan, S. L., Ensrud, K. E., Palermo, L., McGowan, J., Lang, T., Garnero, P., Bouxsein, M., Bilezikian, J. P., & Rosen, C. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa031975 · Cited by 1,168

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

Tang, Y., Wu, X., Lei, W., Pang, L., Wan, C., Shi, Z., Zhao, L., Nagy, T. R., Peng, X., Hu, J., et al. (2009) · Nature Medicine · doi:10.1038/nm.1979 · Cited by 1,165

PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis

Xie, H., Cui, Z., Wang, L., Xia, Z., Hu, Y., Xian, L., Li, C., Xie, L., Crane, J., Wan, M., et al. (2014) · Nature Medicine · doi:10.1038/nm.3668 · Cited by 951

Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate

Pappu, R., Schwab, S. R., Cornelissen, I., Pereira, J. P., Regard, J. B., Xu, Y., Camerer, E., Zheng, Y., Huang, Y., Cyster, J. G., et al. (2007) · Science · doi:10.1126/science.1139221 · Cited by 904

Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6.

Tamura, T., Udagawa, N., Takahashi, N., Miyaura, C., Tanaka, S., Yamada, Y., Koishihara, Y., Ohsugi, Y., Kumaki, K., & Taga, T. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11924 · Cited by 828

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

Winkler, I. G., Sims, N. A., Pettit, A. R., Barbier, V., Nowlan, B., Helwani, F., Poulton, I. J., van Rooijen, N., Alexander, K. A., Raggatt, L. J., et al. (2010) · Blood · doi:10.1182/blood-2009-11-253534 · Cited by 801

Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis

Zhao, C., Irie, N., Takada, Y., Shimoda, K., Miyamoto, T., Nishiwaki, T., Suda, T., & Matsuo, K. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.012 · Cited by 777

Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit

Sims, N. A., & Martin, T. J. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2013.215 · Cited by 745

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

Chang, M. K., Raggatt, L. J., Alexander, K. A., Kuliwaba, J. S., Fazzalari, N. L., Schroder, K., Maylin, E. R., Ripoll, V. M., Hume, D. A., & Pettit, A. R. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.2.1232 · Cited by 715

Osteoclast-derived activity in the coupling of bone formation to resorption

Martin, T. J., & Sims, N. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.004 · Cited by 661

Matrix IGF-1 maintains bone mass by activation of mTOR in mesenchymal stem cells

Xian, L., Wu, X., Pang, L., Lou, M., Rosen, C. J., Qiu, T., Crane, J., Frassica, F., Zhang, L., Rodriguez, J. P., et al. (2012) · Nature Medicine · doi:10.1038/nm.2793 · Cited by 631

Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease.

ERIKSEN, E. F. (1986) · Endocrine Reviews · doi:10.1210/edrv-7-4-379 · Cited by 601

MicroRNA control of bone formation and homeostasis

Lian, J. B., Stein, G. S., van Wijnen, A. J., Stein, J. L., Hassan, M. Q., Gaur, T., & Zhang, Y. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.234 · Cited by 595

Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation

Li, D., Liu, J., Guo, B., Liang, C., Dang, L., Lu, C., He, X., Cheung, H. Y.-S., Xu, L., Lu, C., et al. (2016) · Nature Communications · doi:10.1038/ncomms10872 · Cited by 588

Coupling of bone resorption and formation by RANKL reverse signalling

Ikebuchi, Y., Aoki, S., Honma, M., Hayashi, M., Sugamori, Y., Khan, M., Kariya, Y., Kato, G., Tabata, Y., Penninger, J. M., et al. (2018) · Nature · doi:10.1038/s41586-018-0482-7 · Cited by 557

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

Pederson, L., Ruan, M., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805133106 · Cited by 556

Osteoblasts synthesize and respond to transforming growth factor-type beta (TGF-beta) in vitro.

Robey, P. G., Young, M. F., Flanders, K. C., Roche, N. S., Kondaiah, P., Reddi, A. H., Termine, J. D., Sporn, M. B., & Roberts, A. B. (1987) · The Journal of Cell Biology · doi:10.1083/jcb.105.1.457 · Cited by 550

v-ATPase V0 subunit d2–deficient mice exhibit impaired osteoclast fusion and increased bone formation

Lee, S.-H., Rho, J., Jeong, D., Sul, J., Kim, T. S., Kim, N., Kang, J.-S., Miyamoto, T. K., Suda, T., Lee, S., et al. (2006) · Nature Medicine · doi:10.1038/nm1514 · Cited by 547

Induction of Rapid Osteoblast Differentiation in Rat Bone Marrow Stromal Cell Cultures by Dexamethasone and BMP-2

Rickard, D. J., Sullivan, T. A., Shenker, B. J., Leboy, P. S., & Kazhdan, I. (1994) · Developmental Biology · doi:10.1006/dbio.1994.1022 · Cited by 537

Sphingosine-1-phosphate mobilizes osteoclast precursors and regulates bone homeostasis

Ishii, M., Egen, J. G., Klauschen, F., Meier-Schellersheim, M., Saeki, Y., Vacher, J., Proia, R. L., & Germain, R. N. (2009) · Nature · doi:10.1038/nature07713 · Cited by 515

Suppression of bone formation by osteoclastic expression of semaphorin 4D

Negishi-Koga, T., Shinohara, M., Komatsu, N., Bito, H., Kodama, T., Friedel, R. H., & Takayanagi, H. (2011) · Nature Medicine · doi:10.1038/nm.2489 · Cited by 498

The skeleton: a multi-functional complex organ. The growth plate chondrocyte and endochondral ossification

Mackie, E. J., Tatarczuch, L., & Mirams, M. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0048 · Cited by 459

Mechanical Signaling for Bone Modeling and Remodeling

Robling, A. G., & Turner, C. H. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i4.50 · Cited by 443

Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells.

Zarling, J. M., SHOYAB, M., Marquardt, H., Hanson, M., Lioubin, M. N., & Todaro, G. J. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9739 · Cited by 435

The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation

Everts, V., Delaissé, J. M., Korper, W., Jansen, D. C., Tigchelaar-Gutter, W., Saftig, P., & Beertsen, W. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.1.77 · Cited by 411

Cancellous Bone Remodeling Occurs in Specialized Compartments Lined by Cells Expressing Osteoblastic Markers

Hauge, E. M., Qvesel, D., Eriksen, E. F., Mosekilde, L., & Melsen, F. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1575 · Cited by 397

The coupling of bone formation to bone resorption: A critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis

PARFITT, A. M. (1982) · Metabolic Bone Disease and Related Research · doi:10.1016/0221-8747(82)90002-9 · Cited by 396

BMP‐2, BMP‐4, and PDGF‐bb stimulate chemotactic migration of primary human mesenchymal progenitor cells

Fiedler, J., Röderer, G., Günther, K., & Brenner, R. E. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10309 · Cited by 395

Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL

Sobacchi, C., Frattini, A., Guerrini, M. M., Abinun, M., Pangrazio, A., Susani, L., Bredius, R. G. M., Mancini, G. M. S., Cant, A. J., Bishop, N. J., et al. (2007) · Nature Genetics · doi:10.1038/ng2076 · Cited by 389

Targeting skeletal endothelium to ameliorate bone loss

Xu, R., Yallowitz, A. R., Qin, A., Wu, Z., Shin, D. Y., Kim, J., Debnath, S., Ji, G., Bostrom, M. P., Yang, X., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0020-z · Cited by 380

Osteoblasts isolated from mouse calvaria initiate matrix mineralization in culture.

Ecarot, B., Glorieux, F. H., REST, M. V. D., & Pereira, G. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.96.3.639 · Cited by 359

Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2

Champagne, C. M., Takebe, J., Offenbacher, S., & Cooper, L. F. (2002) · Bone · doi:10.1016/s8756-3282(01)00638-x · Cited by 354

Engagement of Cytotoxic T Lymphocyte–associated Antigen 4 (CTLA-4) Induces Transforming Growth Factor β (TGF-β) Production by Murine CD4+ T Cells

Chen, W., Jin, W., & Wahl, S. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.10.1849 · Cited by 352

Suggested Sequential Mode of Control of Changes in Cell Behaviour in Adult Bone Remodelling

Hattner, R. S., Epker, B. N., & Frost, H. M. (1965) · Nature · doi:10.1038/206489a0 · Cited by 348

Sphingosine 1‐phosphate as a regulator of osteoclast differentiation and osteoclast–osteoblast coupling

Ryu, J., Kim, H. J., Chang, E., Huang, H., Banno, Y., & Hong‐Hee, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601430 · Cited by 332

Localization of RANKL (receptor activator of NFκB ligand) mRNA and protein in skeletal and extraskeletal tissues

Kartsogiannis, V., Zhou, H., Horwood, N. J., Thomas, R. J., Hards, D. K., Quinn, J. M. W., Niforas, P., Ng, K. W., Martin, T. J., & Gillespie, M. T. (1999) · Bone · doi:10.1016/s8756-3282(99)00214-8 · Cited by 324

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

Sun, W., Zhao, C., Li, Y., Wang, L., Nie, G., Peng, J., Wang, A., Zhang, P., Tian, W., Li, Q., et al. (2016) · Cell Discovery · doi:10.1038/celldisc.2016.15 · Cited by 311

Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice

Walker, E. C., McGregor, N. E., Poulton, I. J., Solano, M., Pompolo, S., Fernandes, T. J., Constable, M. J., Nicholson, G. C., Zhang, J., Nicola, N. A., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40568 · Cited by 302

Quantifying the osteocyte network in the human skeleton

Buenzli, P. R., & Sims, N. A. (2015) · Bone · doi:10.1016/j.bone.2015.02.016 · Cited by 300

Autocrine and paracrine roles of sphingosine-1-phosphate

Alvarez, S. E., Milstien, S., & Spiegel, S. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.07.005 · Cited by 293

Wnt10b Increases Postnatal Bone Formation by Enhancing Osteoblast Differentiation

Bennett, C. N., Ouyang, H., Li, Y., Zeng, Q., Gerin, I., Sousa, K. M., Lane, T. F., Krishnan, V., Hankenson, K. D., & MacDougald, O. A. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070810 · Cited by 285

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

Oreffo, R. O. C., Mundy, G. R., Seyedin, S. M., & Bonewald, L. F. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92795-2 · Cited by 285

Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation

Marzia, M., Sims, N. A., Voit, S., Migliaccio, S., Taranta, A., Bernardini, S., Faraggiana, T., Yoneda, T., Mundy, G. R., Boyce, B. F., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.2.311 · Cited by 285

Parathyroid hormone stimulates bone formation and resorption in organ culture: evidence for a coupling mechanism.

Howard, G. A., Bottemiller, B. L., Turner, R. T., Rader, J. I., & Baylink, D. J. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.5.3204 · Cited by 266

Intermittent parathyroid hormone administration converts quiescent lining cells to active osteoblasts

Kim, S. W., Pajevic, P. D., Selig, M., Barry, K. J., Yang, J.-Y., Shin, C. S., Baek, W.-Y., Kim, J.-E., & Kronenberg, H. M. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1665 · Cited by 266

Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo

Ishii, M., Kikuta, J., Shimazu, Y., Meier‐Schellersheim, M., & Germain, R. N. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20101474 · Cited by 266

Sema4D induces angiogenesis through Met recruitment by Plexin B1

Conrotto, P., Valdembri, D., Corso, S., Serini, G., Tamagnone, L., Comoglio, P. M., Bussolino, F., & Giordano, S. (2005) · Blood · doi:10.1182/blood-2004-07-2885 · Cited by 262

Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation

Takeshita, S., Fumoto, T., Matsuoka, K., Park, K.-A., Aburatani, H., Kato, S., Ito, M., & Ikeda, K. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69493 · Cited by 257

miR-214 promotes osteoclastogenesis by targeting Pten/PI3k/Akt pathway

Zhao, C., Sun, W., Zhang, P., Ling, S., Li, Y., Dingsheng, Z., Peng, J., Wang, A., Li, Q., Song, J., et al. (2015) · RNA Biology · doi:10.1080/15476286.2015.1017205 · Cited by 239

Osteogenic differentiation of human mesenchymal stem cells is regulated by bone morphogenetic protein‐6

Friedman, M. S., Long, M. W., & Hankenson, K. D. (2005) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20719 · Cited by 227

Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2−/− mice

Gil-Henn, H., Destaing, O., Sims, N. A., Aoki, K., Alles, N., Neff, L., Sanjay, A., Bruzzaniti, A., Camilli, P. V. D., Baron, R., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200701148 · Cited by 227

Osteoclast-Derived Complement Component 3a Stimulates Osteoblast Differentiation

Matsuoka, K., Park, K.-A., Ito, M., Ikeda, K., & Takeshita, S. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2187 · Cited by 225

Monocyte Exosomes Stimulate the Osteogenic Gene Expression of Mesenchymal Stem Cells

Ekström, K. M., Omar, O., Granéli, C., Wang, X., Vazirisani, F., & Thomsen, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075227 · Cited by 219

Role of IGF-I Signaling in Regulating Osteoclastogenesis

Wang, Y., Nishida, S., Elalieh, H. Z., Long, R. K., Halloran, B. P., & Bikle, D. D. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060610 · Cited by 205

EphrinB2 Regulation by PTH and PTHrP Revealed by Molecular Profiling in Differentiating Osteoblasts

Allan, E. H., Häusler, K. D., Wei, T., Gooi, J. H., Quinn, J. M., Crimeen-Irwin, B., Pompolo, S., Sims, N. A., Gillespie, M. T., Onyia, J. E., et al. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080324 · Cited by 199

Characterization of Regulatory Extracellular Vesicles from Osteoclasts

Huynh, N., VonMoss, L., Smith, D., Rahman, I., Felemban, M. F., Zuo, J., Rody, W. J., McHugh, K. P., & Holliday, L. S. (2016) · Journal of Dental Research · doi:10.1177/0022034516633189 · Cited by 196

T Lymphocytes Amplify the Anabolic Activity of Parathyroid Hormone through Wnt10b Signaling

Terauchi, M., Li, J., Bedi, B., Baek, K., Tawfeek, H. A. W., Galley, S. A., Gilbert, L. C., Nanes, M. S., Zayzafoon, M., Guldberg, R. E., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.07.010 · Cited by 195

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

Sims, N. A., Jenkins, B. J., Quinn, J. M. W., Nakamura, A., Glatt, M., Gillespie, M. T., Ernst, M., & Martin, T. J. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19872 · Cited by 192

Cardiotrophin-1 Is an Osteoclast-Derived Stimulus of Bone Formation Required for Normal Bone Remodeling

Walker, E. C., McGregor, N. E., Poulton, I. J., Pompolo, S., Allan, E. H., Quinn, J. M., Gillespie, M. T., Martin, T. J., & Sims, N. A. (2008) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.080706 · Cited by 190

Transforming Growth Factor-β Stimulates Bone Matrix Apposition and Bone Cell Replication in Cultured Fetal Rat Calvariae*

Hock, J. M., & CANALIS, E. M. (1990) · Endocrinology · doi:10.1210/endo-126-1-421 · Cited by 189

The reversal phase of the bone-remodeling cycle: cellular prerequisites for coupling resorption and formation

Delaissé, J. (2014) · BoneKEy Reports · doi:10.1038/bonekey.2014.56 · Cited by 182

Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

Irie, N., Takada, Y., Watanabe, Y., Matsuzaki, Y., Naruse, C., Asano, M., Iwakura, Y., Suda, T., & Matsuo, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807598200 · Cited by 182

Clinical, genetic, and cellular analysis of 49 osteopetrotic patients: implications for diagnosis and treatment

Fattore, A. D., Peruzzi, B., Rucci, N., Recchia, I., Cappariello, A., Longo, M., Fortunati, D., Ballanti, P., Iacobini, M., Luciani, M., et al. (2005) · Journal of Medical Genetics · doi:10.1136/jmg.2005.036673 · Cited by 181

Platelet-derived growth factor enhances bone cell replication, but not differentiated function of osteoblasts.

Hock, J. M., & CANALIS, E. M. (1994) · Endocrinology · doi:10.1210/endo.134.3.8119182 · Cited by 179

Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo

Furuya, M., Kikuta, J., Fujimori, S., Seno, S., Maeda, H., Shirazaki, M., Uenaka, M., Mizuno, H., Iwamoto, Y., Morimoto, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02541-w · Cited by 175

Osteoclast-secreted SLIT3 coordinates bone resorption and formation

Kim, B.-J., Lee, Y.-S., Lee, S.-Y., Baek, W.-Y., Choi, Y. J., Moon, S. A., Lee, S. H., Kim, J.-E., Chang, E.-J., Kim, E.-Y., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci91086 · Cited by 174

The anabolic effect of human PTH (1–34) on bone formation is blunted when bone resorption is inhibited by the bisphosphonate tiludronate—is activated resorption a prerequisite for the in vivo effect of PTH on formation in a remodeling system?

Delmas, P. D., Vergnaud, P., ARLOT, M. E., Pastoureau, P., Meunier, P. J., & Nilssen, M. H. L. (1995) · Bone · doi:10.1016/8756-3282(95)00113-r · Cited by 171

The Bone Remodeling Compartment: A Circulatory Function for Bone Lining Cells

Parfitt, A. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.9.1583 · Cited by 169

Identification of cell cycle–arrested quiescent osteoclast precursors in vivo

Mizoguchi, T., Muto, A., Udagawa, N., Arai, A., Yamashita, T., Hosoya, A., Ninomiya, T., Nakamura, H., Yamamoto, Y., Kinugawa, S., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200806139 · Cited by 166

Acidification of the Osteoclastic Resorption Compartment Provides Insight into the Coupling of Bone Formation to Bone Resorption

Karsdal, M. A., Henriksen, K., Sørensen, M. G., Gram, J., Schaller, S., Dziegiel, M. H., Heegaard, A., Christophersen, P., Martin, T. J., Christiansen, C., et al. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62269-9 · Cited by 155

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

Reid, I. R., Lowe, C., Cornish, J., Skinner, S. J. M., Hilton, D. J., Willson, T. A., Gearing, D. P., & Martin, T. J. (1990) · Endocrinology · doi:10.1210/endo-126-3-1416 · Cited by 154

Coupling of Bone Resorption and Formation in Real Time: New Knowledge Gained From Human Haversian BMUs

Lassen, N. E., Andersen, T. L., Pløen, G. G., Søe, K., Hauge, E. M., Harving, S., Eschen, G. E. T., & Delaisse, J.-M. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3091 · Cited by 152

Bone density, strength, and formation in adult cathepsin K (−/−) mice

Pennypacker, B. L., Shea, M., Liu, Q., Masarachia, P. J., Säftig, P., Rodan, S. B., Rodan, G. A., & Kimmel, D. B. (2008) · Bone · doi:10.1016/j.bone.2008.08.130 · Cited by 146

The effect of systemically administered PDGF-BB on the rodent skeleton

Mitlak, B., Finkelman, R. D., Hill, E. L., Li, J., Martin, B. A., Smith, T. S., D'Andrea, M., Antoniades, H. N., & Lynch, S. E. (1996) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650110213 · Cited by 133

Characterization of circulating osteoblast lineage cells in humans

Eghbali-Fatourechi, G. Z., Mödder, U. I., Charatcharoenwitthaya, N., Sanyal, A., Undale, A. H., Clowes, J. A., Tarara, J. E., & Khosla, S. (2007) · Bone · doi:10.1016/j.bone.2006.12.064 · Cited by 132

Perspectives: Mechanical loading, estrogen deficiency, and the coupling of bone formation to bone resorption

Rodan, G. A. (1991) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650060602 · Cited by 132

TGF-β Enhances Osteoclast Differentiation in Hematopoietic Cell Cultures Stimulated with RANKL and M-CSF

Galvin, R. J. S., Gatlin, C. L., Horn, J. W., & Fuson, T. R. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1632 · Cited by 132

Osteoclasts Control Osteoblast Chemotaxis via PDGF-BB/PDGF Receptor Beta Signaling

Sanchez-Fernandez, M. A., Gallois, A., Riedl, T., Jurdic, P., & Hoflack, B. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003537 · Cited by 130

Antiresorptive and anabolic agents in the prevention and reversal of bone fragility

Seeman, E., & Martin, T. J. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0172-3 · Cited by 127

Functional soluble CD100/Sema4D released from activated lymphocytes: possible role in normal and pathologic immune responses

Wang, X., Kumanogoh, A., Watanabe, C., Shi, W., Yoshida, K., & Kikutani, H. (2001) · Blood · doi:10.1182/blood.v97.11.3498 · Cited by 125

Characterization of Osteoclasts from Patients Harboring a G215R Mutation in ClC-7 Causing Autosomal Dominant Osteopetrosis Type II

Henriksen, K., Gram, J., Schaller, S., Dahl, B. H., Dziegiel, M. H., Bollerslev, J., & Karsdal, M. A. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63712-1 · Cited by 124

Cord Blood-Derived Macrophage-Lineage Cells Rapidly Stimulate Osteoblastic Maturation in Mesenchymal Stem Cells in a Glycoprotein-130 Dependent Manner

Fernandes, T. J., Hodge, J. M., Singh, P. P., Eeles, D. G., Collier, F., Holten, I. W. R., Ebeling, P. R., Nicholson, G. C., & Quinn, J. M. W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073266 · Cited by 121

Targeting sphingosine-1-phosphate lyase as an anabolic therapy for bone loss

Weske, S., Vaidya, M., Reese, A., Lipinski, K. V. W., Keul, P., Bayer, J. K., Fischer, J. W., Flögel, U., Nelsen, J., Epple, M., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0005-y · Cited by 121

Local Regulators of Skeletal Growth: A Perspective*

CANALIS, E. (1985) · Endocrine Reviews · doi:10.1210/edrv-6-4-544 · Cited by 119

The effect of leukemia inhibitory factor on bone in vivo

Cornish, J., Callon, K. E., King, A., Edgar, S. G., & Reid, I. R. (1993) · Endocrinology · doi:10.1210/endo.132.3.8440191 · Cited by 117

Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films

Lees, R. L., Sabharwal, V. K., & Heersche, J. N. M. (2001) · Bone · doi:10.1016/s8756-3282(00)00433-6 · Cited by 113

Osteoclasts secrete non-bone derived signals that induce bone formation

Karsdal, M. A., Neutzsky-Wulff, A. V., Dziegiel, M. H., Christiansen, C., & Henriksen, K. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.168 · Cited by 112

Cthrc1 Is a Positive Regulator of Osteoblastic Bone Formation

Kimura, H. J., Kwan, K. M., Zhang, Z., Deng, J. M., Darnay, B. G., Behringer, R. R., Nakamura, T., Crombrugghe, B. D., & Akiyama, H. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003174 · Cited by 111

Topographically induced bone formation in vitro: Implications for bone implants and bone grafts

Gray, C., BOYDE, A., & Jones, S. J. (1996) · Bone · doi:10.1016/8756-3282(95)00456-4 · Cited by 110

STIMULATION OF OSTEOCLAST DIFFERENTIATION IN VITRO BY MOUSE ONCOSTATIN M, LEUKAEMIA INHIBITORY FACTOR, CARDIOTROPHIN-1 AND INTERLEUKIN 6: SYNERGY WITH DEXAMETHASONE

Richards, C. D., Langdon, C. M., Deschamps, P. A., Pennica, D., & Shaughnessy, S. G. (2000) · Cytokine · doi:10.1006/cyto.1999.0635 · Cited by 104

Time-related changes in the ultrastructure of osteoclasts after injection of parathyroid hormone in young rats

Holtrop, M. E., King, G. J., Cox, K. A., & Reit, B. (1979) · Calcified Tissue International · doi:10.1007/bf02441175 · Cited by 101

EphrinB2/EphB4 inhibition in the osteoblast lineage modifies the anabolic response to parathyroid hormone

Takyar, F. M., Tonna, S. J., Ho, P. W. M., Crimeen‐Irwin, B., Baker, E. K., Martin, T. J., & Sims, N. A. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1820 · Cited by 100

Skeletal Growth Factors

Hosking, D. J. (2001) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2001.01165.x · Cited by 100

The chemokine and scavenger receptor CXCL16/SR-PSOX is expressed in human vascular smooth muscle cells and is induced by interferon γ

Wågsäter, D., Olofsson, P. S., Norgren, L., Stenberg, B., & Sirsjö, A. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.10.160 · Cited by 99

Human osteoblasts synthesize and respond to platelet-derived growth factor

Zhang, L., Leeman, E. L., Carnes, D., & Graves, D. T. (1991) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1991.261.2.c348 · Cited by 99

Regulation of an extrathymic T-cell development pathway by oncostatin M

Clegg, C. H., Rulffes, J. T., Wallace, P. M., & Haugen, H. S. (1996) · Nature · doi:10.1038/384261a0 · Cited by 99

Increased presence of capillaries next to remodeling sites in adult human cancellous bone

Kristensen, H. B., Andersen, T. L., Marcussen, N., Rolighed, L., & Delaisse, J.-M. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1760 · Cited by 97

EphrinB2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis

Tonna, S. J., Takyar, F. M., Vrahnas, C., Crimeen‐Irwin, B., Ho, P. W. M., Poulton, I. J., Brennan, H. J., McGregor, N. E., Allan, E. H., Nguyen, H., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-254300 · Cited by 94

Solubilized Bone Morphogenetic Protein (BMP) from Mouse Osteosarcoma and Rat Demineralized Bone Matrix

Hanamura, H., Higuchi, Y., Nakagawa, M., Iwata, H., Nogami, H., & Urist, M. R. (1980) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-198005000-00045 · Cited by 94

Stress-concentrating effect of resorption lacunae in trabecular bone

McNamara, L. M., der Linden, J. C. V., Weinans, H., & Prendergast, P. J. (2005) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2004.12.027 · Cited by 92

Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors

Ota, K., Quint, P. S., Weivoda, M. M., Ruan, M. M., Pederson, L. G., Westendorf, J. J., Khosla, S., & Oursler, M. J. (2013) · Bone · doi:10.1016/j.bone.2013.07.023 · Cited by 92

Expression and Synthesis of Bone Morphogenetic Proteins by Osteoclasts: A Possible Path to Anabolic Bone Remodeling

Garimella, R., Tague, S. E., Zhang, J., Belibi, F., Nahar, N. N., Sun, B. H., Insogna, K. L., Wang, J., & Anderson, H. C. (2008) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2008.950394 · Cited by 86

The biological roles of the third component of complement in osteoclast formation

Sato, T., Abe, E., Jin, C., Hong, M. H., Katagiri, T., Kinoshita, T., Amizuka, N., Ozawa, H., & Suda, T. (1993) · Endocrinology · doi:10.1210/endo.133.1.8319587 · Cited by 83

Non‐resorbing osteoclasts induce migration and osteogenic differentiation of mesenchymal stem cells

Kreja, L., Brenner, R. E., Tautzenberger, A., Liedert, A., Friemert, B., Ehrnthaller, C., Huber-Lang, M. S., & Ignatius, A. A. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22406 · Cited by 81

Stimulation of Bone Formation in Cortical Bone of Mice Treated with a Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-binding Peptide That Possesses Osteoclastogenesis Inhibitory Activity

Furuya, Y., Inagaki, A., Khan, M., Mori, K., Penninger, J. M., Nakamura, M., Udagawa, N., Aoki, K., Ohya, K., Uchida, K., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426080 · Cited by 77

Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength

Henriksen, K., Flores, C., Thomsen, J. S., Brüel, A.-M., Thudium, C. S., Neutzsky-Wulff, A. V., Langenbach, G. E. J., Sims, N., Askmyr, M., Martin, T. J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027482 · Cited by 77

Control of Bone Resorption by Semaphorin 4D Is Dependent on Ovarian Function

Dacquin, R., Domenget, C., Kumanogoh, A., Kikutani, H., Jurdic, P., & Machuca‐Gayet, I. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026627 · Cited by 77

Early reversal cells in adult human bone remodeling: osteoblastic nature, catabolic functions and interactions with osteoclasts

Abdelgawad, M. E., Delaisse, J.-M., Hinge, M., Jensen, P. R., Alnaimi, R. W., Rolighed, L., Engelholm, L. H., Marcussen, N., & Andersen, T. L. (2016) · Histochemistry and Cell Biology · doi:10.1007/s00418-016-1414-y · Cited by 76

Bone morphogenetic proteins 5 and 6 stimulate osteoclast generation

Wutzl, A., Brozek, W., Lernbass, I., Rauner, M., Hofbauer, G., Schopper, C., Watzinger, F., Peterlik, M., & Pietschmann, P. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30615 · Cited by 74

Contrasting roles of leukemia inhibitory factor in murine bone development and remodeling involve region-specific changes in vascularization

Poulton, I. J., McGregor, N. E., Pompolo, S., Walker, E. C., & Sims, N. A. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1485 · Cited by 73

Innervation is higher above Bone Remodeling Surfaces and in Cortical Pores in Human Bone: Lessons from patients with primary hyperparathyroidism

Sayilekshmy, M., Hansen, R. B., Delaissé, J., Rolighed, L., Andersen, T. L., & Heegaard, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-41779-w · Cited by 72

Increased autophagy in EphrinB2-deficient osteocytes is associated with elevated secondary mineralization and brittle bone

Vrahnas, C., Blank, M., Dite, T. A., Tatarczuch, L., Ansari, N., Crimeen-Irwin, B., Nguyen, H., Forwood, M. R., Hu, Y., Ikegame, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11373-9 · Cited by 70

Implications of Osteoblast-Osteoclast Interactions in the Management of Osteoporosis by Antiresorptive Agents Denosumab and Odanacatib

Sims, N. A., & Ng, K. W. (2014) · Current Osteoporosis Reports · doi:10.1007/s11914-014-0196-1 · Cited by 62

Divergence in macrophage insulin-like growth factor-I (IGF-I) synthesis induced by TNF-α and prostaglandin E2

Fournier, T., Riches, D. W. H., Winston, B. W., Rose, D. M., Young, S. K., Noble, P. W., Lake, F., & Henson, P. M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.4.2123 · Cited by 62

Autocrine and Paracrine Regulation of the Murine Skeleton by Osteocyte-Derived Parathyroid Hormone-Related Protein

Ansari, N., Ho, P. W. M., Crimeen‐Irwin, B., Poulton, I. J., Brunt, A. R., Forwood, M. R., Pajevic, P. D., Gooi, J. H., Martin, T. J., & Sims, N. A. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3291 · Cited by 61

TGF-β regulates sclerostin expression via the ECR5 enhancer

Loots, G. G., Keller, H., Leupin, O., Murugesh, D. K., Collette, N. M., & Genetos, D. C. (2011) · Bone · doi:10.1016/j.bone.2011.11.016 · Cited by 59

A joined role of canopy and reversal cells in bone remodeling — Lessons from glucocorticoid-induced osteoporosis

Jensen, P. R., Andersen, T. L., Hauge, E., Bollerslev, J., & Delaissé, J. (2014) · Bone · doi:10.1016/j.bone.2014.12.004 · Cited by 57

Bone morphogenetic protein 2 increases insulin-like growth factor I and II transcripts and polypeptide levels in bone cell cultures

CANALIS, E. M., & Gabbitas, B. (1994) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650091221 · Cited by 53

Cthrc1, a Novel Circulating Hormone Regulating Metabolism

Stohn, J. P., Perreault, N. G., Wang, Q., Liaw, L., & Lindner, V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047142 · Cited by 49

Activated complement factor 3 is associated with liver fat and liver enzymes: the CODAM study

Wlazlo, N., van Greevenbroek, M. M. J., Ferreira, I., Jansen, E. H. J. M., Feskens, E. J. M., Kallen, C., Schalkwijk, C. G., Bravenboer, B., & Stehouwer, C. D. A. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12093 · Cited by 44

Atherogenic Lipids Induce High-Density Lipoprotein Uptake and Cholesterol Efflux in Human Macrophages by Up-Regulating Transmembrane Chemokine CXCL16 without Engaging CXCL16-Dependent Cell Adhesion

Barlic, J., Zhu, W., & Murphy, P. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804112 · Cited by 42

Generation of the first autosomal dominant osteopetrosis type II (ADO2) disease models

Alam, I., Gray, A. K., Chu, K., Ichikawa, S., Mohammad, K. S., Capannolo, M., Capulli, M., Maurizi, A., Muraca, M., Teti, A. M., et al. (2013) · Bone · doi:10.1016/j.bone.2013.10.021 · Cited by 42

Skeletal Growth Factors.

Hosking, D. J. (2001) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2001.01165.x · Cited by 42

Influence of cell isolation, cell culture density, and cell nutrition on differentiation of rat calvarial osteoblast-like cells in vitro

Gerber, I., & Gwynn, I. A. (2001) · European Cells and Materials · doi:10.22203/ecm.v002a02 · Cited by 41

A specific subtype of osteoclasts secretes factors inducing nodule formation by osteoblasts

Henriksen, K., Andreassen, K. V., Thudium, C. S., Gudmann, K. N. S., Moscatelli, I., Crüger-Hansen, C., Schulz, A., Dziegiel, M. H., Richter, J., Karsdal, M. A., et al. (2012) · Bone · doi:10.1016/j.bone.2012.06.007 · Cited by 40

Bone scaffolds loaded with siRNA-Semaphorin4d for the treatment of osteoporosis related bone defects

Zhang, Y., Wei, L., Miron, R. J., Shi, B., & Bian, Z. (2016) · Scientific Reports · doi:10.1038/srep26925 · Cited by 40

Correlation between Absence of Bone Remodeling Compartment Canopies, Reversal Phase Arrest, and Deficient Bone Formation in Post-Menopausal Osteoporosis

Andersen, T. L., Hauge, E., Rolighed, L., Bollerslev, J., Kjærsgaard‐Andersen, P., & Delaissé, J. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.12.005 · Cited by 39

Estrogen Receptors Alpha (ESR1) and Beta (ESR2) Are Expressed in Circulating Human Lymphocytes

Scariano, J. K., EMERY-COHEN, A. J., Pickett, G., Morgan, M., Simons, P. C., & Alba, F. M. (2008) · Journal of Receptors and Signal Transduction · doi:10.1080/10799890802084614 · Cited by 39

A reversal phase arrest uncoupling the bone formation and resorption contributes to the bone loss in glucocorticoid treated ovariectomised aged sheep

Andreasen, C. M., Ding, M. L., Overgaard, S., Bollen, P. J. A., & Andersen, T. L. (2015) · Bone · doi:10.1016/j.bone.2015.02.014 · Cited by 37

Inhibition of osteoclast differentiation and collagen antibody-induced arthritis by CTHRC1

Jin, Y.-R., Stohn, J. P., Wang, Q., Nagano, K., Baron, R., Bouxsein, M., Rosen, C. J., Adarichev, V. A., & Lindner, V. (2017) · Bone · doi:10.1016/j.bone.2017.01.022 · Cited by 37

A Comparison of Osteoclast-Rich and Osteoclast-Poor Osteopetrosis in Adult Mice Sheds Light on the Role of the Osteoclast in Coupling Bone Resorption and Bone Formation

Thudium, C. S., Moscatelli, I., Flores, C., Thomsen, J. S., Brüel, A., Gudmann, N. S., Hauge, E.-M., Karsdal, M. A., Richter, J., & Henriksen, K. (2014) · Calcified Tissue International · doi:10.1007/s00223-014-9865-4 · Cited by 36

The inhibitory effects of a RANKL-binding peptide on articular and periarticular bone loss in a murine model of collagen-induced arthritis: a bone histomorphometric study

Kato, G., Shimizu, Y., Arai, Y., Suzuki, N., Sugamori, Y., Maeda, M., Takahashi, M., Tamura, Y., Wakabayashi, N., Murali, R., et al. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0753-8 · Cited by 36

Distinct pathways mediate transcriptional regulation of platelet-derived growth factor B/c-sis expression.

Daniel, T. O., & Fen, Z. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)77708-4 · Cited by 34

Talking among Ourselves: Paracrine Control of Bone Formation within the Osteoblast Lineage

Tonna, S. J., & Sims, N. A. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9738-2 · Cited by 33

A New Method for Identification of Cement Lines in Undecalcified, Plastic Embedded Sections of Bone

Villanueva, A. R., Sypitkowski, C., & PARFITT, A. M. (1986) · Stain Technology · doi:10.3109/10520298609110713 · Cited by 32

Leukemia inhibitory factor is mitogenic to osteoblasts

Cornish, J., Callon, K. E., Edgar, S. G., & Reid, I. R. (1997) · Bone · doi:10.1016/s8756-3282(97)00144-0 · Cited by 31

Bone Remodeling and Bone Structure

Eriksen, E. F., Vesterby, A., Kassem, M. S., Melsen, F., & Mosekilde, L. (1993) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-77991-6_2 · Cited by 31

Leukemia Inhibitory Factor Secretion is a Predictor and Indicator of Early Progenitor Status in Adult Bone Marrow Stromal Cells

Whitney, M. J., Lee, A., Ylöstalo, J., Zeitouni, S., Tucker, A., & Gregory, C. A. (2008) · Tissue Engineering Part A · doi:10.1089/ten.tea.2007.0266 · Cited by 28

A supra-cellular model for coupling of bone resorption to formation during remodeling: lessons from two bone resorption inhibitors affecting bone formation differently

Jensen, P. R., Andersen, T. L., Pennypacker, B. L., Duong, L. T., Engelholm, L. H., & Delaissé, J. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.12.036 · Cited by 24

The Physiological Basis of Metabolic Bone Disease

Nordin, B. E. C., Morris, H. A., & Anderson, P. (2014) · CRC Press eBooks · doi:10.1201/b16906 · Cited by 22

Gene expression profiles induced by growth factors in in vitro cultured osteoblasts

Robubi, A., Berger, C., Schmid, M., Huber, K., Engel, A., & Krugluger, W. (2014) · Bone and Joint Research · doi:10.1302/2046-3758.37.2000231 · Cited by 22

The Dissection of Human Autosomal Recessive Osteopetrosis Identifies an Osteoclast-Poor Form Due to RANKL Deficiency

Frattini, A., Vezzoni, P., VILLA, A. M., & Sobacchi, C. (2007) · Cell Cycle · doi:10.4161/cc.6.24.5105 · Cited by 13

Ultrastructural observation on cells meeting the histological criteria for preosteoblasts - a study in the mouse tibial metaphysis

Narimatsu, K., Li, M., de Freitas, P. H. L., Sultana, S., Ubaidus, S., Kojima, T., Zhucheng, L., Ying, G., Suzuki, R., Yamamoto, T., et al. (2010) · Journal of Electron Microscopy · doi:10.1093/jmicro/dfq021 · Cited by 12

Coupling of bone formation and resorption

Sims, N. A., & Martin, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00010-5 · Cited by 11

Osteoblast-Osteoclast Communication and Bone Homeostasis

Kim, J., Lin, C., Stavre, Z., Greenblatt, M. B., & Shim, J. (2020) · Cells · doi:10.3390/cells9092073 · Cited by 1,266

Bone remodeling: an operational process ensuring survival and bone mechanical competence

Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482

Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications

Noirrit‐Esclassan, E., Valera, M., Trémollières, F., Arnal, J., Lenfant, F., Fontaine, C., & Vinel, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041568 · Cited by 259

Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis

Zhu, X., Chan, Y.-T., Yung, P. S., Tuan, R. S., & Jiang, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.607764 · Cited by 218

Macrophages and Bone Remodeling

Weivoda, M. M., & Bradley, E. W. (2023) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4773 · Cited by 166

Osteoclast-Derived Coupling Factors in Bone Remodeling

Henriksen, K., Karsdal, M. A., & Martin, T. J. (2013) · Calcified Tissue International · doi:10.1007/s00223-013-9741-7 · Cited by 146

Osteoclast-derived activity in the coupling of bone formation to resorption

Martin, T. J., & Sims, N. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.12.004 · Cited by 661

Molecular Mechanisms in Coupling of Bone Formation to Resorption

Martin, T. J., Gooi, J. H., & Sims, N. A. (2009) · Critical Reviews in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v19.i1.40 · Cited by 167

Coupling of bone formation and resorption

Sims, N. A., & Martin, T. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00010-5 · Cited by 11

Beyond resorption-driven coupling: a multi-layered framework for osteoclast–osteoblast communication and its therapeutic consequences

Qiu, H., Liu, S., Jiang, Y., Lai, Y., Lin, Q., & Huang, A. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1821292 · Cited by 2