Cited by 1,460Diet and metabolism studiesLipid metabolism and biosynthesisLipid metabolism and disorders

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Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

McGarry, J D, Foster, D W·1980·Annual Review of Biochemistry

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The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More

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Crossref · 10.1146/annurev.bi.49.070180.002143

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The rôle of mitochondrial pyruvate transport in the stimulation by glucagon and phenylephrine of gluconeogenesis from l -lactate in isolated rat hepatocytes
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Roles of the N- and C-terminal domains of carnitine palmitoyltransferase I isoforms in malonyl-CoA sensitivity of the enzymes: insights from expression of chimaeric proteins and mutation of conserved histidine residues
SWANSON, S. T., Foster, D. W., McGarry, J., & BROWN, N. F. (1998) · Biochemical Journal · doi:10.1042/bj3350513 · Cited by 55
Self-citation
Sigmoid kinetics of purified beef heart mitochondrial carnitine palmitoyltransferase. Effect of pH and malonyl-CoA.
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In vivo evidence of defective postprandial and postabsorptive free fatty acid metabolism in familial combined hyperlipidemia
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The Ketogenic Diet for the Treatment of Epilepsy: A Challenge for Nutritional Neuroscientists
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“Neurons and glia possess the requisite enzymes to break down BHB and AcAc into acetyl CoA fragments (BHB dehydrogenase and 3-oxoacid-CoA transferase, respectively).”
BackgroundInfluential
Fuel selection in intestinal cells
Duée, P., Darcy‐Vrillon, B., Blachier, F., & MOREL, M.-T. (1995) · Proceedings of The Nutrition Society · doi:10.1079/pns19950039 · Cited by 54
“(Adapted from Vidal et al. 1988, 1989.) oxidation and esterification (McGarry & Foster, 1980).”
Background
Characterization of Metabolic Changes during a Protocol for Inducing Lactation Ketosis in Dairy Cows
Mills, S. E., Beitz, D. C., & Young, J. W. (1986) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(86)80413-1 · Cited by 54
“Production of ketone bodies may be controlled, in part, by regulation of the mitochondrial acyl-coenzyme A (CoA) shuttle enzyme, carnitine palmitoyhransfer ase (CPT I). In nonruminants malonyl-CoA is a potent inhibitor of CPT I and is thought to play a major role in the regulation of fatty acid oxidation ( 28 ).”
Background
Effect of pH on malonyl-CoA inhibition of carnitine palmitoyltransferase I
Stephens, T. W., Cook, G. A., & Harris, R. A. (1983) · Biochemical Journal · doi:10.1042/bj2120521 · Cited by 54
Peroxisomal oxidation of erucic acid suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation in the rat liver
Chen, X., Shang, L., Deng, S., Li, P., Chen, K., Gao, T., Zhang, X., Chen, Z., & Zeng, J. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013583 · Cited by 55
“As the core molecule in fatty acid synthesis, malonyl-CoA was identified to be the molecule responsible for the inhibition of CPT1a, the critical enzyme in the transfer of long-chain fatty acids into mitochondria, thereby suppressing mitochondrial fatty acid oxidation and stimulating fatty acid synthesis (18, 19).”
Background
L-Carnitine Stimulates Lipolysis via Induction of the Lipolytic Gene Expression and Suppression of the Adipogenic Gene Expression in 3T3-L1 Adipocytes
Lee, M.-S., Lee, H., Lee, H., & Kim, Y. (2006) · Journal of Medicinal Food · doi:10.1089/jmf.2006.9.468 · Cited by 53
“22,23 Mitochondrial CPT-Ia is inhibited by malonyl-CoA, which is a precursor for fatty acid synthesis, 22 and the sensitivity of CPT-Ia to malonyl-CoA inhibition is increased by insulin and decreased by fasting.”
3Glucose and ketone body kinetics in diabetic ketoacidosis
Miles, J. M., & Gerich, J. E. (1983) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(83)80043-7 · Cited by 52
Regulation of Cardiac Energy Metabolism in Newborn
Onay-Beşi̇kçi̇, A. (2006) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-006-9123-9 · Cited by 58
“Malonyl CoA, the substrate for fatty acid synthase in hepatic lipogenesis, is also a potent physiological inhibitor of the enzyme [54].”
Background
The Effects of a High-fat or High-sucrose Diet on Serum Lipid Profiles, Hepatic Acyl-CoA Synthetase, Carnitine Palmitoyltransferase-I, and the Acetyl-CoA Carboxylase mRNA Levels in Rats
Ryu, M.-H., & Cha, Y. (2003) · BMB Reports · doi:10.5483/bmbrep.2003.36.3.312 · Cited by 53
“This reaction is the first step of the transport of long-chain fatty acids from the cytosol into the mitochondrial matrix for fatty acid oxidation (McGarry and Foster, 1980; McGarry and Brown, 1997).”
Background
Glucose appearance rate following protein ingestion in normal subjects.
Khan, M. A. I., Gannon, M. C., & Nuttall, F. Q. (1992) · Journal of the American College of Nutrition · doi:10.1080/07315724.1992.10718270 · Cited by 53
Peroxisomal fatty acid oxidation and inhibitors of the mitochondrial carnitine palmitoyltransferase I in isolated rat hepatocytes
Skorin, C., Cecilia Necochea, K., Johow, V., Soto, U., Grau, A., Bremer, J., & Leighton, F. (1992) · Biochemical Journal · doi:10.1042/bj2810561 · Cited by 53
Regulation of phosphoenolpyruvate carboxykinase (GTP) synthesis in rat liver cells. Rapid induction of specific mRNA by glucagon or cyclic AMP and permissive effect of dexamethasone.
Salavert, A., & Iynedjian, P. B. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)33463-x · Cited by 53
Hepatic mitochondrial inner membrane properties and carnitine palmitoyltransferase A and B. Effect of diabetes and starvation
Brady, L. J., Silverstein, L. J., Hoppel, C. L., & Brady, P. S. (1985) · Biochemical Journal · doi:10.1042/bj2320445 · Cited by 53
Hypothalamic malonyl-CoA and the control of food intake
Gao, S., Moran, T. H., Lopaschuk, G. D., & Butler, A. A. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.07.014 · Cited by 56
“In the mitochondria, the acyltransferase activity of CPT-1 catalyzes the conversion of long-chain fatty acyl-CoA (the esterified fatty acid) to long-chain acylcarnitine, which is translocated across the mitochondrial membrane and into the matrix for oxidative metabolism [61,62].”
Interaction of β-lactam antibiotics with the mitochondrial carnitine/acylcarnitine transporter
Pochini, L., Galluccio, M., Scumaci, D., Giangregorio, N., Tonazzi, A., Palmieri, F., & Indiveri, C. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.03.003 · Cited by 52
Organization of the human liver carnitine palmitoyltransferase 1 gene (CPT1A) and identification of novel mutations in hypoketotic hypoglycaemia
Gobin, S., Bonnefont, J., Prip‐Buus, C., Mugnier, C., Ferrec, M., Demaugre, F., Saudubray, J., Rostane, H., Djouadi, F., Wilcox, W. R., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0752-0 · Cited by 52
“This reaction constitutes the rate limiting step of mitochondrial FAO (McGarry et al. 1977; McGarry and Foster 1980 ).”
Background
Circadian clock controls rhythms in ketogenesis by interfering with PPARα transcriptional network
Mezhnina, V., Ebeigbe, O. P., Velingkaar, N., Poe, A., Sandlers, Y. I., & Kondratov, R. V. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205755119 · Cited by 55
Ketone Bodies and Cardiovascular Disease: An Alternate Fuel Source to the Rescue
Manolis, A. S., Manolis, T. A., & Manolis, A. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043534 · Cited by 56
“During physiological conditions of reduced availability of carbohydrates and an excess of fatty acids, ketone bodies are transferred to tissues outside the liver for final oxidation [4,27].”
Background
Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4
Arbonés-Mainar, J. M., Johnson, L. A., Torres-Pérez, E., Whitlock, A. E. G., Pérez‐Díaz, S., Raber, J., & Maeda, N. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.93 · Cited by 52
Streptozotocin diabetes increases mRNA expression of ketogenic enzymes in the rat heart
Cook, G. A., Lavrentyev, E. N., Pham, K. M., & Park, E. A. (2016) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2016.11.012 · Cited by 51
“The major interest of our laboratory has been the regulation of fatty acid metabolism in liver and heart at the level of carnitine palmitoyltransferase I (Cpt1), which is located in the outer membranes of mitochondria in all mammalian cells and represents the predominant site for regulation of mitochondrial fatty acid…”
Background
Lipid metabolism in patients with chronic hyperglycemia after an episode of acute pancreatitis
Gillies, N. A., Pendharkar, S. A., Singh, R. G., Asrani, V. M., & Petrov, M. S. (2016) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2016.12.037 · Cited by 51
“636), it is unlikely that an up-regulation of FFA betaoxidation would explain the lack of association between CHAP and FFA in this cohort [41,84].”
Background
Maternal undernutrition induces fetal hepatic lipid metabolism disorder and affects the development of fetal liver in a sheep model
Xue, Y., Guo, C., Hu, F., Zhu, W., & Mao, S. (2019) · The FASEB Journal · doi:10.1096/fj.201900406r · Cited by 53
“It is widely known that ketogenesis is regulated by substrate availability (26, 27) and ketogenesis-associated genes (28).”
Background
Linking bioenergetic function of mitochondria to tissue-specific molecular fingerprints
Kappler, L., Hoene, M., Hu, C., von Toerne, C., Li, J., Bleher, D., Hoffmann, C., Böhm, A., Kollipara, L., Zischka, H., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00088.2019 · Cited by 52
Hepatic Energy and Substrate Metabolism: A Possible Metabolic Basis for Early Nutritional Support in Cirrhotic Patients
Müller, M. J. (1998) · Nutrition · doi:10.1016/s0899-9007(97)00390-0 · Cited by 50
Interrelations between C4 Ketogenesis, C5 Ketogenesis, and Anaplerosis in the Perfused Rat Liver
Deng, S., Zhang, G., Kasumov, T., Roe, C. R., & Brunengraber, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.048744 · Cited by 51
Role of Hyperinsulinemia and Glucose Intolerance in the Pathogenesis of Nonalcoholic Fatty Liver in Patients with Normal Body Weight
Lee, J. H., Rhee, P., Lee, J. K., et al. (1998) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.1998.13.1.10 · Cited by 51
Decreased serum apolipoprotein B-100 and A-I concentrations in cows with ketosis and left displacement of the abomasum
Oikawa, S., Katoh, N., Kawawa, F., et al. (1997) · American Journal of Veterinary Research · doi:10.2460/ajvr.1997.58.02.121 · Cited by 51
Diabetic ketoacidosis : current views on pathogenesis and treatment
Keller, U. B. (1986) · Diabetologia · doi:10.1007/bf00456113 · Cited by 48
“The role of the insulin/glucagon ratio in regulating ketogenesis in vivo is based experimentally mainly on studies in rodents [ 29 ] and in dogs [30].”
Background
Regulation of mitochondrial carnitine palmitoyl transferases from liver and extrahepatic tissues
Saggerson, D., Ghadiminejad, I., & Awan, M. (1992) · Advances in Enzyme Regulation · doi:10.1016/0065-2571(92)90023-s · Cited by 51
AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine
Li, M., Wang, Y., Wei, X., Cai, W.-F., Wu, J., Zhu, M., Wang, Y., Liu, Y., Xiong, J., Qu, Q., et al. (2024) · Cell Research · doi:10.1038/s41422-024-00985-6 · Cited by 52
Impact of Glucoraphanin-Mediated Activation of Nrf2 on Non-Alcoholic Fatty Liver Disease with a Focus on Mitochondrial Dysfunction
Xu, L., Nagata, N., & Ota, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20235920 · Cited by 51
“Moreover, a high malonyl-CoA level inhibits CPT-I and decreases fatty-acid β-oxidation [61].”
Background
Volume overload hypertrophy of the newborn heart slows the maturation of enzymes involved in the regulation of fatty acid metabolism
Kantor, P. F., Robertson, M. A., Coe, J. Y., & Lopaschuk, G. D. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00063-7 · Cited by 50
“A key enzyme involved in fatty acid oxidation is carnitine palmitoyltransferase-1, which is located on the outer mitochondrial membrane, and acts as the ratelimiting step for mitochondrial fatty acid uptake (1).”
Background
The biological origin of ketotic dicarboxylic aciduria
Mortensen, P. B., & Gregersen, N. (1982) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(82)90132-1 · Cited by 50
Ketogenesis in the living rat followed by carbon-13 NMR spectroscopy
Cross, T. A., Pahl-Wostl, C., Oberhaensli, R. D., Aue, W. P., Keller, U. B., & Seelig, J. (1984) · Biochemistry · doi:10.1021/bi00321a018 · Cited by 50
The Physiological and Pathological Role of Acyl-CoA Oxidation
Szrok-Jurga, S., Czumaj, A., Turyn, J., Hebanowska, A., Świerczyński, J., Śledziński, T., & Stelmańska, E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914857 · Cited by 58
“The increased level of ketogenesis also occurs in subjects on a ketogenic diet and patients with severely uncontrolled diabetes [151,152].”
Background
Differential Effects of Typical Korean Versus American-Style Diets on Gut Microbial Composition and Metabolic Profile in Healthy Overweight Koreans: A Randomized Crossover Trial
Shin, J., Jung, S., Kim, S.-A., Kang, M., Kim, M. S., Joung, H., Hwang, G., & Shin, D. (2019) · Nutrients · doi:10.3390/nu11102450 · Cited by 49
“Surplus fatty acid availability enhances fatty acid oxidation to produce ATP instead of glucose oxidation [96].”
Background
Therapeutic alternative of the ketogenic Mediterranean diet to improve mitochondrial activity in Amyotrophic Lateral Sclerosis (ALS): A Comprehensive Review
Caplliure‐Llopis, J., Chamba, T. P., Carrera‐Juliá, S., Cuerda‐Ballester, M., Drehmer, E., López‐Rodriguez, M. M., & Ortí, J. E. D. L. R. (2019) · Food Science & Nutrition · doi:10.1002/fsn3.1324 · Cited by 51
Dynamic Metabolome Analysis Reveals the Metabolic Fate of Medium-Chain Fatty Acids in AML12 Cells
Fushimi, T., Izumi, Y., Takahashi, M., Hata, K., Murano, Y., & Bamba, T. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04723 · Cited by 45
Cyclic Dipeptides in the Induction of Maturation for Cancer Therapy
Graz, C. J. M., Grant, G. D., Brauns, S. C. A., et al. (2000) · Journal of Pharmacy and Pharmacology · doi:10.1211/0022357001773535 · Cited by 49
“The acetyl±CoA can be used by the tricarboxylic acid cycle to produce either adenosine 50-triphosphate or acetoacetate (McGarry & Foster 1980).”
Method
Metabolic fate of non-esterified fatty acids in isolated hepatocytes from newborn and young pigs. Evidence for a limited capacity for oxidation and increased capacity for esterification
Pégorier, J. P., Duée, P., Girard, J. R., et al. (1983) · Biochemical Journal · doi:10.1042/bj2120093 · Cited by 49
Comparative Analysis of Blood Chemical Values in Primary Ketosis and Abomasal Displacement in Cows
Itoh, N., Koiwa, M., HATSUGAYA, A., et al. (1998) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1998.tb00830.x · Cited by 49
Pseudoketogenesis in the perfused rat heart.
Fink, G., Desrochers, S., Rosiers, C. D., Garneau, M., David, F., Daloze, T., Landau, B. R., & Brunengraber, H. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81320-0 · Cited by 49
Immunoquantitative Analysis of Human Carnitine Palmitoyltransferase I and II Defects
Demaugre, F., Bonnefont, J., Cepanec, C., et al. (1990) · Pediatric Research · doi:10.1203/00006450-199005000-00016 · Cited by 49
The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase.
Cook, G. A. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61140-8 · Cited by 48
Lipid molecular order in liver mitochondrial outer membranes, and sensitivity of carnitine palmitoyltransferase I to malonyl‐CoA
Zammit, V. A., Corstorphine, C. G., Kolodziej, M. P., & Fraser, F. W. (1998) · Lipids · doi:10.1007/s11745-998-0217-7 · Cited by 49
“The property of CPT I that makes it possible for the reaction it catalyzes to exert such a level of control is its inhibition by malonyl-CoA ( 4 ).”
Background
Fatty acids reverse the cyclic AMP inhibition of triacylglycerol and phosphatidylcholine synthesis in rat hepatocytes
Pelech, S., Pritchard, P. H., Brindley, D. N., et al. (1983) · Biochemical Journal · doi:10.1042/bj2160129 · Cited by 49
Fatty acid metabolism and lipid secretion by perfused livers from rats fed laboratory stock and sucrose-rich diets
Yamamoto, M., Yamamoto, I., Tanaka, Y., et al. (1987) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)38605-3 · Cited by 49
Effects of SGLT-2 inhibitors on adipose tissue distribution in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials
Wang, X., Wu, N., Sun, C., Jin, D., & Lu, H. (2023) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-023-01085-y · Cited by 54
“Glucagon activates PPAR-α [54] and CPT-1A [55] and stimulates the increase in gluconeogenesis and liver fat β-oxidation, leading to the conversion of carbohydrate metabolism to fatty acid metabolism, which helps reduce liver fat deposition [56].”
Background
Molecular characterization, tissue distribution and kinetic analysis of carnitine palmitoyltransferase I in juvenile yellow catfish Pelteobagrus fulvidraco
Zheng, J., Luo, Z., Zhu, Q., Chen, Q.-L., & Gong, Y. (2012) · Genomics · doi:10.1016/j.ygeno.2012.12.002 · Cited by 48
“CPT II, located on the inner mitochondrial membrane, catalyzes a second esterification, generating palmitoyl-CoA and carnitine inside the mitochondrial matrix [4].”
CrbpI Modulates Glucose Homeostasis and Pancreas 9-cis-Retinoic Acid Concentrations
Kane, M. A., Folias, A. E., Pingitore, A., Perri, M., Krois, C. R., Ryu, J. Y., Cione, E., & Napoli, J. L. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05516-11 · Cited by 48
“Elevated glucagon secretion drives liver gluconeogenesis, as shown by the PTT, which also contributes to hyperglycemia (14, 26, 30).”
Background
The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding
Henriksen, B. S., Curtis, M. E., Fillmore, N., Cardon, B. R., Thomson, D. M., & Hancock, C. R. (2013) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-5-29 · Cited by 49
“This disease has been reported to affect from 10-30 percent (about 90 million people) of the adult population in the United States, making it the most common chronic liver condition among adults (42, 44, 46, 50, 52, 53, 55, 63, 66).”
Background
Thioridazine: a selective inhibitor of peroxisomal β‐oxidation in vivo
Branden, C. V. D., & Roels, F. (1985) · FEBS Letters · doi:10.1016/0014-5793(85)81270-9 · Cited by 48
Enhancement of activities relative to fatty acid oxidation in the liver of rats depleted of l-carnitine by d-carnitine and a γ-butyrobetaine hydroxylase inhibitor
Tsoko, M., Beauseigneur, F., Gresti, J., Niot, I., Demarquoy, J., Boichot, J., Bezard, J. A., Rochette, L., & Clouet, P. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00019-v · Cited by 48
Mitochondrial phosphoenolpyruvate carboxykinase deficiency
Clayton, P. T., Hyland, Κ., Brand, M. P., & Leonard, J. V. (1986) · European Journal of Pediatrics · doi:10.1007/bf00441851 · Cited by 48
Regulation of intracellular acetyl-CoA carboxylase by ATP depletors mimics the action of the 5′-AMP-activated protein kinase
Witters, L. A., Nordlund, A. C., & Marshall, L. S. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)92107-u · Cited by 48
Fatty acid oxidation and ketogenesis during development
Girard, J. R., Duée, P., Ferré, P., Pégorier, J. P., Escrivá, F., & Decaux, J. (1985) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19850221 · Cited by 48
Molecular cloning of rat mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase and detection of the corresponding mRNA and of those encoding the remaining enzymes comprising the ketogenic 3-hydroxy-3-methylglutaryl-CoA cycle in central nervous system of suckling rat
CULLINGFORD, E. T., DOLPHIN, T. C., Bhakoo, K. K., Peuchen, S., Canevari, L., & CLARK, B. J. (1998) · Biochemical Journal · doi:10.1042/bj3290373 · Cited by 48
Evaluation and Management of the Critically Ill Adult With Diabetic Ketoacidosis
Long, B., Willis, G. C., Lentz, S. A., Koyfman, A., & Gottlieb, M. A. (2020) · Journal of Emergency Medicine · doi:10.1016/j.jemermed.2020.06.059 · Cited by 52
Exercise Intensity Modulation of Hepatic Lipid Metabolism
Lira, F. S., Carnevali, L. C., Zanchi, N. E., dos Santos, R. V. T., Lavoie, J.-M., & Seelaender, M. C. L. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/809576 · Cited by 49
“Therefore, CPT-1 activity can be limiting for fatty acid oxidation and ketogenesis in liver [39].”
Background
Health Effects of Dietary Oxidized Tyrosine and Dityrosine Administration in Mice with Nutrimetabolomic Strategies
Yang, Y., Zhang, H., Yan, B., Zhang, T., Gao, Y. H., Shi, Y., & Le, G. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02003 · Cited by 47
NMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells
Chen, C., Gao, J., Wang, T.-S., Guo, C., Yan, Y., Mao, C., Gu, L., Yang, Y., Li, Z., & Liu, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-27359-4 · Cited by 47
Glutaminolysis and Glycolysis Are Essential for Optimal Replication of Marek’s Disease Virus
Boodhoo, N., Kamble, N. M., Sharif, S., & Behboudi, S. (2019) · Journal of Virology · doi:10.1128/jvi.01680-19 · Cited by 49
“To further assess the role of fatty acid -oxidation on MDV replication, we used malonyl-CoA and etomoxir to study the role of CTP1a on MDV replication.”
Background
Dietary polyunsaturated fatty acids and hepatic gene expression
Jump, D. Β., Thelen, A. P., & Mater, M. K. (1999) · Lipids · doi:10.1007/bf02562292 · Cited by 44
Hepatic ketogenesis in newborn pigs is limited by low mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase activity
Duée, P., Pégorier, J. P., Quant, P. A., Herbin, C., Kohl, C., & Girard, J. R. (1994) · Biochemical Journal · doi:10.1042/bj2980207 · Cited by 47
Role of glycerol 3-phosphate and glycerophosphate acyltransferase in the nutritional control of hepatic triacylglycerol synthesis
Declercq, P. E., Debeer, L. J., & Mannaerts, G. P. (1982) · Biochemical Journal · doi:10.1042/bj2040247 · Cited by 47
Swelling of rat hepatocytes activates acetyl-CoA carboxylase in parallel to glycogen synthase
Baquet, A., Maisin, L., & Hue, L. (1991) · Biochemical Journal · doi:10.1042/bj2780887 · Cited by 47
Carnitine palmitoyltransferase 1 facilitates fatty acid oxidation in a non-cell-autonomous manner
Choi, J., Smith, D. M., Scafidi, S., Riddle, R. C., & Wolfgang, M. J. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.115006 · Cited by 52
Assessment of Fatty Acid Beta Oxidation in Cells and Isolated Mitochondria
Rogers, G. W., Nadanaciva, S., Swiss, R. L., Divakaruni, A. S., & Will, Y. (2014) · Current Protocols in Toxicology · doi:10.1002/0471140856.tx2503s60 · Cited by 46
Vagal afferents are not necessary for the satiety effect of the gut lipid messenger oleoylethanolamide
Azari, E. K., Ramachandran, D., Weibel, S., Arnold, M., Romano, A., Gaetani, S., Langhans, W., & Mansouri, A. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00067.2014 · Cited by 46
Intra- and inter-individual metabolic profiling highlights carnitine and lysophosphatidylcholine pathways as key molecular defects in type 2 diabetes
Diamanti, K., Cavalli, M., Pan, G., Pereira, M. J., Kumar, C., Skrtic, S., Grabherr, M. G., Risérus, U., Eriksson, J. W., Komorowski, J., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-45906-5 · Cited by 49
Long-term exposure to bisphenol A or S promotes glucose intolerance and changes hepatic mitochondrial metabolism in male Wistar rats
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Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH
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The role of macrophages in obesity-driven chronic liver disease
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Authors: McGarry, J. D., & Foster, D. W.
ORCID: McGarry, J D
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 1980-06
Volume: 49
Issue: 1
Pages: 395-420
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.bi.49.070180.002143
OpenAlex: W2178164598
Cited by: 1,460
References: 0
Citations by year: 2026: 14 · 2025: 28 · 2024: 30 · 2023: 41 · 2022: 39 · 2021: 25 · 2020: 42 · 2019: 47 · 2018: 26 · 2017: 27 · 2016: 33 · 2015: 28 · 2014: 36 · 2013: 35 · 2012: 24
FWCI: 47.01
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: hepatic fatty acid oxidation, ketone synthesis, Hippo signaling pathway, hepatic metabolism, tissue growth regulation, organ size control, cell fate determination
MeSH terms: Acetyl Coenzyme A, Adipose Tissue, Animals, Carnitine, Carnitine Acyltransferases, Fatty Acids, Fatty Acids, Nonesterified, Glucagon, Glycogen, Insulin, Ketone Bodies, Liver, Malonyl Coenzyme A, Models, Biological, Triglycerides, Meglutol

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Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

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