Cited by 1,460Diet and metabolism studiesLipid metabolism and biosynthesisLipid metabolism and disorders

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Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

McGarry, J D, Foster, D W·1980·Annual Review of Biochemistry

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The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More

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Mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase: a control enzyme in ketogenesis
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Regulation of ketogenesis and the renaissance of carnitine palmitoyltransferase
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“Abbreviations Apo B : apolipoprotein B ASH : alcoholic steatohepatitis AZT : zidovudine Bid : BH3 interacting domain death agonist CPT-I : carnitine palmitoyltransferase I CYP : cytochrome P450 DdI : didanosine d4T : stavudine FFA : free fatty acid 4-HNE : 4-hydroxynonenal IL-8 : interleukin-8 MDA : malondialdehyde Mn…”
BackgroundInfluential
Identification of an isozymic form of acetyl-CoA carboxylase.
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“To more specifically examine β-oxidation, we measured ketones, which represent the predominant fate of hepatic acetyl-CoA in the fasted state (McGarry and Foster, 1980; Puchalska and Crawford, 2017).”
Background
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
Wolfgang, M. J., Kurama, T., Dai, Y., Suwa, A., Asaumi, M., Matsumoto, S.-I., Cha, S. H., Shimokawa, T., & Lane, M. D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602205103 · Cited by 259
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De novo lipogenesis in humans: metabolic and regulatory aspects
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“Malonyl-CoA inhibits transport of FA-CoAs into mitochondria by inhibiting carnitine acyl-transferase I activity (McGarry & Foster, 1980).”
BackgroundInfluential
Isozyme-nonselective N-Substituted Bipiperidylcarboxamide Acetyl-CoA Carboxylase Inhibitors Reduce Tissue Malonyl-CoA Concentrations, Inhibit Fatty Acid Synthesis, and Increase Fatty Acid Oxidation in Cultured Cells and in Experimental Animals
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“The combination of higher insulin concentrations, reduced fatty acid availability to tissues with increased delivery of extracellular glucose, and a lipogenic, presumably antiketogenic milieu (33) in the liver (all measured in this study), and increased intracellular glycogen stores (presumed) might explain the marked…”
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Minireview: Glucagon in the Pathogenesis of Hypoglycemia and Hyperglycemia in Diabetes
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“The only important allosteric control on fatty acid catabolism that is known is the potent inhibitory effect of malonyl-CoA on the carnitine palmitoyltransferase situated on the outer face of the inner mitochondrial membrane (McGarry, Takabayashi & Foster, 1978; McGarry & Foster, 1980).”
Background
Effect of iron depletion in carbohydrate-intolerant patients with clinical evidence of nonalcoholic fatty liver disease
Facchini, F. S., Hua, N. W., & Stoohs, R. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.32403 · Cited by 233

Authors: McGarry, J. D., & Foster, D. W.
ORCID: McGarry, J D
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 1980-06
Volume: 49
Issue: 1
Pages: 395-420
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.bi.49.070180.002143
OpenAlex: W2178164598
Cited by: 1,460
References: 0
Citations by year: 2026: 14 · 2025: 28 · 2024: 30 · 2023: 41 · 2022: 39 · 2021: 25 · 2020: 42 · 2019: 47 · 2018: 26 · 2017: 27 · 2016: 33 · 2015: 28 · 2014: 36 · 2013: 35 · 2012: 24
FWCI: 47.01
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: hepatic fatty acid oxidation, ketone synthesis, Hippo signaling pathway, hepatic metabolism, tissue growth regulation, organ size control, cell fate determination
MeSH terms: Acetyl Coenzyme A, Adipose Tissue, Animals, Carnitine, Carnitine Acyltransferases, Fatty Acids, Fatty Acids, Nonesterified, Glucagon, Glycogen, Insulin, Ketone Bodies, Liver, Malonyl Coenzyme A, Models, Biological, Triglycerides, Meglutol

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Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

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