Cited by 1,460Diet and metabolism studiesLipid metabolism and biosynthesisLipid metabolism and disorders

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Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

McGarry, J D, Foster, D W·1980·Annual Review of Biochemistry

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The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More

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Crossref · 10.1146/annurev.bi.49.070180.002143

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“This process is leveraged during periods of high fatty acid oxidation and diminished carbohydrate availability, as is evident during the neonatal period, fasting, starvation, prolonged exercise, and adherence to a ketogenic diet (KD), where it can become a major contributor to whole-organismal metabolism (Koeslag et a…”
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“When acetyl-CoA derived from glycolysis and lipid β-oxidation exceeds the capacity of the Kreb's cycle, it will produce ketone bodies: acetoacetate, 3-D-HB and acetone (McGarry and Foster, 1980).”
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“Three different sources contribute to the hepatic levels of free fatty acids: de novo lipogenesis within hepatocytes from acetyl-CoA, uptake of circulating plasma free fatty acids released by adipose tissue with lipolysis and hydrolysis of intestinal chylomicrons (McGarry and Foster, 1980).”
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Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation
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“In neurons, during starvation, KBs are used by ACAT1 to generate acetyl-CoA in the mitochondria for energy (6).”
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“24 hydroxybutyrate, and acetone, and are produced from fatty acids in the liver, especially during fasting and extensive prolonged exercise (McGarry and Foster, 1980).”
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“During fasting, the oxidation of long-chain fatty acids in liver mitochondria produces ketone bodies, enhances gluconeogenesis, and therefore contributes to the maintenance of normoglycemia (2).”
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Self-citation
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Background
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Authors: McGarry, J. D., & Foster, D. W.
ORCID: McGarry, J D
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 1980-06
Volume: 49
Issue: 1
Pages: 395-420
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.bi.49.070180.002143
OpenAlex: W2178164598
Cited by: 1,460
References: 0
Citations by year: 2026: 14 · 2025: 28 · 2024: 30 · 2023: 41 · 2022: 39 · 2021: 25 · 2020: 42 · 2019: 47 · 2018: 26 · 2017: 27 · 2016: 33 · 2015: 28 · 2014: 36 · 2013: 35 · 2012: 24
FWCI: 47.01
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: hepatic fatty acid oxidation, ketone synthesis, Hippo signaling pathway, hepatic metabolism, tissue growth regulation, organ size control, cell fate determination
MeSH terms: Acetyl Coenzyme A, Adipose Tissue, Animals, Carnitine, Carnitine Acyltransferases, Fatty Acids, Fatty Acids, Nonesterified, Glucagon, Glycogen, Insulin, Ketone Bodies, Liver, Malonyl Coenzyme A, Models, Biological, Triglycerides, Meglutol

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Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production

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