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Regulation of Hepatic Fatty Acid Oxidation and Ketone Body Production
Abstract
The Hippo pathway was initially discovered in Drosophila melanogaster as a key regulator of tissue growth. It is an evolutionarily conserved signaling cascade regulating numerous biological processes, including cell growth and fate decision, organ size ...Read More
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“Glucagon stimulates hepatic glycogenolysis and ketogenesis, and the decrease in insulin suppresses hepatocyte malonyl-coenzyme A (CoA) synthesis and lipogenesis, with concomitant activation of FAO (21, 22).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [22]
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Renal Tubular Acidosis in Carnitine Palmitoyltransferase Type 1 Deficiency
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Activation of PPAR α and PPAR β/δ regulates Sertoli cell metabolism
Regueira, M., Riera, M. F., Galardo, M. N., Pellizzari, E. H., Cigorraga, S. B., & Meroni, S. B. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.10.006 · Cited by 57
Metadata
- Authors
- McGarry, J. D., & Foster, D. W.
- ORCID
- McGarry, J D
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1980-06
- Volume
- 49
- Issue
- 1
- Pages
- 395-420
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2178164598
- Cited by
- 1,460
- References
- 0
- Citations by year
- 2026: 14 · 2025: 28 · 2024: 30 · 2023: 41 · 2022: 39 · 2021: 25 · 2020: 42 · 2019: 47 · 2018: 26 · 2017: 27 · 2016: 33 · 2015: 28 · 2014: 36 · 2013: 35 · 2012: 24
- FWCI
- 47.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- hepatic fatty acid oxidation, ketone synthesis, Hippo signaling pathway, hepatic metabolism, tissue growth regulation, organ size control, cell fate determination
- MeSH terms
- Acetyl Coenzyme A, Adipose Tissue, Animals, Carnitine, Carnitine Acyltransferases, Fatty Acids, Fatty Acids, Nonesterified, Glucagon, Glycogen, Insulin, Ketone Bodies, Liver, Malonyl Coenzyme A, Models, Biological, Triglycerides, Meglutol
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