Cited by 712DNA Repair MechanismsDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

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FIDELITY MECHANISMS IN DNA REPLICATION

Echols, Harrison, Goodman, Myron F.·1991·Annual Review of Biochemistry

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Abstract

BASE INSERTION SELECTIVITY BY DNA POL YMERASES . The Base 1''lSertion Pathway . Structural Aspects to Base Selection by DNA Polymerases . Polymerase Insertion Errors . Fidelity Assays and Major Conclusions . Error Avoidance in Base Insertion----General Conclusions ..... .

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Crossref · 10.1146/annurev.bi.60.070191.002401

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de Buendı́a, P. G. (1998) · Mutation Research/DNA Repair · doi:10.1016/s0921-8777(97)00063-3 · Cited by 13
Remarkable Sensitivity to DNA Base Shape in the DNA Polymerase Active Site
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“Mutation rates further increases once a defective mutation occurs in the error correction machineries, such as mismatch repair, or proofreading in a DNA polymerase (Echols & Goodman 1991; Schaaper 1993).”
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“DNA polymerases are likely to play a key role in this process since it is their task to ensure ®delity of DNA replication; they possess the crucial catalytic functions to ensure ®delity: template-speci®c selection and incorporation of nucleotides, exonucleolytic proof-reading and elongation of primer termini (Echols a…”
Background
The Enhanced DNA Replication Fidelity of a Mutant Herpes Simplex Virus Type 1 DNA Polymerase Is Mediated by an Improved Nucleotide Selectivity and Reduced Mismatch Extension Ability
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Authors: Echols, H., & Goodman, M. F.
Affiliations: University of California, Berkeley (US)
ORCID: Goodman, Myron F.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 1991-06
Volume: 60
Issue: 1
Pages: 477-511
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.bi.60.070191.002401
OpenAlex: W2138476183
Cited by: 712
References: 0
Citations by year: 2026: 3 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 12 · 2014: 16 · 2013: 20 · 2012: 18
FWCI: 12.30
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Francis Crick Institute
Vlaamse regering
National Institutes of Health (5r01ca041655-10, 5r01gm042554-13)
National Cancer Institute (CA 41655)
National Institute of General Medical Sciences (GM 42554, GM 21422)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: DNA replication fidelity, DNA polymerase, insertion errors, polymerase structure, error prevention
MeSH terms: DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Escherichia coli, Kinetics, Mutation, SOS Response, Genetics

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FIDELITY MECHANISMS IN DNA REPLICATION

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