Cited by 712DNA Repair MechanismsDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

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FIDELITY MECHANISMS IN DNA REPLICATION

Echols, Harrison, Goodman, Myron F.·1991·Annual Review of Biochemistry

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Abstract

BASE INSERTION SELECTIVITY BY DNA POL YMERASES . The Base 1''lSertion Pathway . Structural Aspects to Base Selection by DNA Polymerases . Polymerase Insertion Errors . Fidelity Assays and Major Conclusions . Error Avoidance in Base Insertion----General Conclusions ..... .

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Crossref · 10.1146/annurev.bi.60.070191.002401

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“The most substantial cause of spontaneous mutation could be deamination CPT (Frederico et al., 1990; Echols & Goodman, 1991; Lindahl, 1993; Kreutzer & Essigmann, 1998; Frank & Lobry, 1999).”
Background
Dynamics of Nucleotide Incorporation: Snapshots Revealed by 2-Aminopurine Fluorescence Studies
Hariharan, C., Bloom, L. B., Helquist, S. A., Kool, E. T., & Reha-Krantz, L. J. (2006) · Biochemistry · doi:10.1021/bi051644s · Cited by 46
“Three steps in the nucleotide incorporation pathway have been proposed to be important for ensuring high fidelity nucleotide incorporation (11, 12): (1) formation of a pre-insertion complex (for example formation of complexes II and III, Scheme 1), (2) a post-binding conformational change that evaluates the accuracy o…”
Background
Effect of the Oxidized Guanosine Lesions Spiroiminodihydantoin and Guanidinohydantoin on Proofreading by Escherichia coli DNA Polymerase I (Klenow Fragment) in Different Sequence Contexts
Kornyushyna, O., & Burrows, C. J. (2003) · Biochemistry · doi:10.1021/bi0350755 · Cited by 46
Improved nucleotide selectivity and termination of 3′-OH unblocked reversible terminators by molecular tuning of 2-nitrobenzyl alkylated HOMedU triphosphates
Litosh, V. A., Wu, W., Stupi, B. P., Wang, J., Morris, S. E., Hersh, M. N., & Metzker, M. L. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkq1293 · Cited by 46
Incorporation of cytosine arabinoside monophosphate into DNA at internucleotide linkages by human DNA polymerase alpha
Perrino, F. W., & Mekosh, H. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50053-3 · Cited by 45
Exonucleolytic proofreading by p53 protein
Bakhanashvili, M. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02075.x · Cited by 47
Fidelity of DNA synthesis exhibited in vitro by the reverse transcriptase of the lentivirus equine infectious anemia virus
Bakhanashvili, M., & Hizi, A. (1993) · Biochemistry · doi:10.1021/bi00080a030 · Cited by 46
Molecular Evolution of 18S rDNA in Angiosperms: Implications for Character Weighting in Phylogenetic Analysis
Soltis, P. S., & Soltis, D. E. (1998) · Springer eBooks · doi:10.1007/978-1-4615-5419-6_7 · Cited by 44
The origin of spontaneous point mutations in DNA via Löwdin mechanism of proton tunneling in DNA base pairs: Cure with covalent base pairing*
Kryachko, E. S. (2002) · International Journal of Quantum Chemistry · doi:10.1002/qua.975 · Cited by 46
Genetic adaptation of bacteria to chlorinated aromatic compounds
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Kinetic Analysis of the Coding Properties of O6-Methylguanine in DNA: The Crucial Role of the Conformation of the Phosphodiester Bond
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DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase
Xia, S., Wang, J., & Konigsberg, W. H. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3079048 · Cited by 44
Is there adequate ionization mechanism of the spontaneous transitions? Quantum-chemical investigation
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Abortive recombination in Escherichia coli ruv mutants blocks chromosome partitioning
Ishioka, K., Fukuoh, A., Iwasaki, H., et al. (1998) · Genes to Cells · doi:10.1046/j.1365-2443.1998.00185.x · Cited by 44
“By a mechanism yet to be elucidated, replication resumes downstream of the lesion (Khidhir et al. 1985; Echols & Goodman 1991), leaving a gap opposite the lesion (Rupp & Howard-Flanders 1968).”
Background
Development and use of an in vitro HSV-tk forward mutation assay to study eukaryotic DNA polymerase processing of DNA alkyl lesions
Eckert, K. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.7.1450 · Cited by 44
Exploring the role of large conformational changes in the fidelity of DNA polymerase β
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“Of course, there might be additional challenging problems, such as the fact that in reality when Dg<Dg(2)–(3) there may be transitions between these states that are not sampled by the FEP/US simulation.”
BackgroundSelf-citation
Heterogeneity of Genome and Proteome Content in Bacteria, Archaea, and Eukaryotes
Karlin, S., Brocchieri, L., Trent, J. D., Blaisdell, B. E., & Mrázek, J. (2002) · Theoretical Population Biology · doi:10.1006/tpbi.2002.1606 · Cited by 43
“Many DNA repair enzymes recognize shapes or lesions in DNA structures more than specific sequences (Echols and Goodman, 1991).”
Background

Authors: Echols, H., & Goodman, M. F.
Affiliations: University of California, Berkeley (US)
ORCID: Goodman, Myron F.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 1991-06
Volume: 60
Issue: 1
Pages: 477-511
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.bi.60.070191.002401
OpenAlex: W2138476183
Cited by: 712
References: 0
Citations by year: 2026: 3 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 12 · 2014: 16 · 2013: 20 · 2012: 18
FWCI: 12.30
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Francis Crick Institute
Vlaamse regering
National Institutes of Health (5r01ca041655-10, 5r01gm042554-13)
National Cancer Institute (CA 41655)
National Institute of General Medical Sciences (GM 42554, GM 21422)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: DNA replication fidelity, DNA polymerase, insertion errors, polymerase structure, error prevention
MeSH terms: DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Escherichia coli, Kinetics, Mutation, SOS Response, Genetics

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FIDELITY MECHANISMS IN DNA REPLICATION

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