Cited by 712DNA Repair MechanismsDNA and Nucleic Acid ChemistryRNA and protein synthesis mechanisms

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FIDELITY MECHANISMS IN DNA REPLICATION

Echols, Harrison, Goodman, Myron F.·1991·Annual Review of Biochemistry

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Abstract

BASE INSERTION SELECTIVITY BY DNA POL YMERASES . The Base 1''lSertion Pathway . Structural Aspects to Base Selection by DNA Polymerases . Polymerase Insertion Errors . Fidelity Assays and Major Conclusions . Error Avoidance in Base Insertion----General Conclusions ..... .

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Crossref · 10.1146/annurev.bi.60.070191.002401

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Molecular Dynamics Free-Energy Simulations of the Binding Contribution to the Fidelity of T7 DNA Polymerase
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Rapid gene cloning using terminator primers and modular vectors
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UV irradiation of Escherichia coli modulates mutagenesis at a site-specific ethenocytosine residue on M13 DNA. Evidence for an inducible recA-independent effect
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Fidelity of Eucaryotic DNA Polymerase δ Holoenzyme fromSchizosaccharomyces pombe
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Das erweiterte genetische Alphabet
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Background
The L561A Substitution in the Nascent Base-Pair Binding Pocket of RB69 DNA Polymerase Reduces Base Discrimination
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“This technique, we term the Magnification via Nucleotide Imbalance Fidelity (MagNIFi) assay, takes advantage of the observation that error rates increase pro-portionally to imbalances in nucleotide concentrations (29– 31).”
Method
Klenow Fragment−DNA Interaction Required for the Incorporation of Nucleotides Opposite Guanine and O6-Methylguanine
Spratt, T. E. (1997) · Biochemistry · doi:10.1021/bi971253g · Cited by 27
Extending the Understanding of Mutagenicity: Structural Insights into Primer-extension Past a Benzo[a]pyrene Diol Epoxide-DNA adduct
Perlow, R. A., & Broyde, S. B. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00187-6 · Cited by 27
UVM, an ultraviolet-inducible RecA-independent mutagenic phenomenon in Escherichia coli.
Palejwala, V. A., Pandya, G. A., Bhanot, O. S., Solomon, J. J., Murphy, H. S., Dunman, P. M., & Humayun, M. Z. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47004-4 · Cited by 27
Structure of Purine−Purine Mispairs during Misincorporation and Extension by Escherichia coli DNA Polymerase I
Kretulskie, A. M., & Spratt, T. E. (2006) · Biochemistry · doi:10.1021/bi052306u · Cited by 26
Rapid incorporation kinetics and improved fidelity of a novel class of 3′-OH unblocked reversible terminators
Gardner, A. F., Wang, J., Wu, W., Karouby, J., Li, H., Stupi, B. P., Jack, W. E., Hersh, M. N., & Metzker, M. L. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks330 · Cited by 26
Selection-induced mutations.
Hall, B. G. (1992) · Current Opinion in Genetics and Development · doi:10.1016/s0959-437x(05)80120-0 · Cited by 26
DNA Mismatch Repair and Colon Cancer
Marra, G., & Jiricny, J. (2006) · Springer eBooks · doi:10.1007/1-4020-3764-3_4 · Cited by 25
[9] DNA polymerases from hyperthermophiles
Hogrefe, H. H., Cline, J., Lovejoy, A. E., & Nielson, K. B. (2001) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(01)34461-0 · Cited by 25
Thermodynamic and in Vitro Replication Studies of an Intrastrand G[8-5]C Cross-Link Lesion
Gu, C., & Wang, Y. (2005) · Biochemistry · doi:10.1021/bi050036+ · Cited by 25
Perspective on Mutagenesis and Repair: The Standard Model and Alternate Modes of Mutagenesis
Miller, J. H. (2005) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230590954153 · Cited by 25
“This fidelity is enhanced both by editing subunits of the polymerase itself (Scheuermann et al., 1983; Scheuermann & Echols, 1984; Echols & Goodman, 1991), and by enzymes that recognize and correct replication errors (mismatch repair; Figure 2; reviewed in Modrich, 1991; Modrich & Lahue, 1996;…”
Background
Roles of replicative and specialized DNA polymerases in frameshift mutagenesis: Mutability of Salmonella typhimurium strains lacking one or all of SOS-inducible DNA polymerases to 26 chemicals
Kokubo, K., Yamada, M., Kanke, Y., & Nohmi, T. (2005) · DNA repair · doi:10.1016/j.dnarep.2005.06.016 · Cited by 25
Functional recA, lexA, umuD, umuC, polA, and polB genes are not required for the Escherichia coli UVM response
Palejwala, V. A., Wang, G. E., Murphy, H. S., et al. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.21.6041-6048.1995 · Cited by 25
“According to a recent interpretation of the SOS hypothesis, a nucleoprotein complex that includes the UmuD9C peptides, the RecA* protein, and the normal replication factors including DNA polymerase III (pol III) holoenzyme (a ‘‘mutasome’’) is assembled at the lesion site and is responsible for translesion synthesis (2…”
BackgroundMethod

Authors: Echols, H., & Goodman, M. F.
Affiliations: University of California, Berkeley (US)
ORCID: Goodman, Myron F.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 1991-06
Volume: 60
Issue: 1
Pages: 477-511
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.bi.60.070191.002401
OpenAlex: W2138476183
Cited by: 712
References: 0
Citations by year: 2026: 3 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 12 · 2014: 16 · 2013: 20 · 2012: 18
FWCI: 12.30
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Francis Crick Institute
Vlaamse regering
National Institutes of Health (5r01ca041655-10, 5r01gm042554-13)
National Cancer Institute (CA 41655)
National Institute of General Medical Sciences (GM 42554, GM 21422)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: DNA replication fidelity, DNA polymerase, insertion errors, polymerase structure, error prevention
MeSH terms: DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Escherichia coli, Kinetics, Mutation, SOS Response, Genetics

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FIDELITY MECHANISMS IN DNA REPLICATION

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