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FIDELITY MECHANISMS IN DNA REPLICATION
Abstract
BASE INSERTION SELECTIVITY BY DNA POL YMERASES . The Base 1''lSertion Pathway . Structural Aspects to Base Selection by DNA Polymerases . Polymerase Insertion Errors . Fidelity Assays and Major Conclusions . Error Avoidance in Base Insertion----General Conclusions ..... .
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“The geometries of A⅐T and G⅐C base pairs are remarkably similar to each other but differ from mismatched base pairs (15,19,24,31,32).”
From DNA Replication Fidelity (2004) · cites this paper as [31]
In the citing paper
“This tight fit is consistent with a concept that emerged about 25 years ago (reviewed in Refs.15 and 31) that nucleotide selectivity largely depends on geometric selection for the shape and size of correct Watson-Crick base pairs.”
From DNA Replication Fidelity (2004) · cites this paper as [31]
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Metadata
- Authors
- Echols, H., & Goodman, M. F.
- Affiliations
- University of California, Berkeley (US)
- ORCID
- Goodman, Myron F.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1991-06
- Volume
- 60
- Issue
- 1
- Pages
- 477-511
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2138476183
- Cited by
- 712
- References
- 0
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 4 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 9 · 2017: 15 · 2016: 9 · 2015: 12 · 2014: 16 · 2013: 20 · 2012: 18
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Francis Crick Institute
- Vlaamse regering
- National Institutes of Health (5r01ca041655-10, 5r01gm042554-13)
- National Cancer Institute (CA 41655)
- National Institute of General Medical Sciences (GM 42554, GM 21422)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- DNA replication fidelity, DNA polymerase, insertion errors, polymerase structure, error prevention
- MeSH terms
- DNA Damage, DNA-Directed DNA Polymerase, DNA Replication, Escherichia coli, Kinetics, Mutation, SOS Response, Genetics
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