Cited by 3,932interferon and immune responsesCytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

The DOI matches its Crossref record; 322 of the 322 references it cites were found in a registry or an index.

HOW CELLS RESPOND TO INTERFERONS

Stark, George R., Kerr, Ian M., Williams, Bryan R. G., Silverman, Robert H., Schreiber, Robert D.·1998·Annual Review of Biochemistry

DOI 10.1146/annurev.biochem.67.1.227

Open this paper in CoChat — free account

Abstract

Interferons play key roles in mediating antiviral and antigrowth responses and in modulating immune response. The main signaling pathways are rapid and direct. They involve tyrosine phosphorylation and activation of signal transducers and activators of transcription factors by Janus tyrosine kinases at the cell membrane, followed by release of signal transducers and activators of transcription and their migration to the nucleus, where they induce the expression of the many gene products that determine the responses. Ancillary pathways are also activated by the interferons, but their effects on cell physiology are less clear. The Janus kinases and signal transducers and activators of transcription, and many of the interferon-induced proteins, play important alternative roles in cells, raising interesting questions as to how the responses to the interferons intersect with more general aspects of cellular physiology and how the specificity of cytokine responses is maintained.

Integrity signals

Registry

Crossref · 10.1146/annurev.biochem.67.1.227

Cites

322 of 322 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Items 201–322 of 322

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products
Reich, N. C., Pine, R. I., Levy, D. E., & Darnell, J. E., Jr. (1988) · Journal of Virology · doi:10.1128/jvi.62.1.114-119.1988 · Cited by 125
Activation of the ppp(A2'p)nA system in interferon-treated, Herpes simplex virus-infected cells and evidence for novel inhibitors of the ppp(A2'p)nA-dependent RNase
CAYLEY, P. J., DAVIES, J. A., McCullagh, K. G., & Kerr, I. M. (1984) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1984.tb08355.x · Cited by 125
Self-citation
The Apoptosis Pathway Triggered by the Interferon-Induced Protein Kinase PKR Requires the Third Basic Domain, Initiates Upstream of Bcl-2, and Involves ICE-like Proteases1
Lee, S. B., Rodrı́guez, D., Rodríguez, J. R., & Estéban, M. (1997) · Virology · doi:10.1006/viro.1997.8494 · Cited by 124
Association of the Interferon-dependent Tyrosine Kinase Tyk-2 with the Hematopoietic Cell Phosphatase
Yetter, A., Shahab Uddin, M. S., Krolewski, J. J., Jiao, H., Yi, T., & Platanias, L. C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.31.18179 · Cited by 123
Tyrosine phosphorylation of the alpha and beta subunits of the type I interferon receptor. Interferon-beta selectively induces tyrosine phosphorylation of an alpha subunit-associated protein.
Platanias, L. C., Shahab Uddin, M. S., & Colamonici, O. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32371-2 · Cited by 122
Tick-borne thogoto virus infection in mice is inhibited by the orthomyxovirus resistance gene product Mx1
Haller, O., Frese, M., Rost, D., Nuttall, P. A., & Kochs, G. (1995) · Journal of Virology · doi:10.1128/jvi.69.4.2596-2601.1995 · Cited by 121
Overlapping sites for constitutive and induced DNA binding factors involved in interferon‐stimulated transcription.
Dale, T. C., Rosen, J. M., Guille, M., Lewin, A. R., Porter, A., Kerr, I. M., & Stark, G. R. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb03444.x · Cited by 121
Self-citation
Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells
Epperson, D. E., Arnold, D., Spies, T. A., et al. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.149.10.3297 · Cited by 119
Janus Kinase-dependent Activation of Insulin Receptor Substrate 1 in Response to Interleukin-4, Oncostatin M, and the Interferons
Burfoot, M. S., Rogers, N. C., Watling, D., Smith, J. M., Pons, S., Paonessaw, G., Pellegrini, S., White, M. F., & Kerr, I. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24183 · Cited by 119
Self-citation
Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity
Ponten, A., Sick, C., Weeber, M., Haller, O., & Kochs, G. (1997) · Journal of Virology · doi:10.1128/jvi.71.4.2591-2599.1997 · Cited by 119
The role of the growth hormone (GH) receptor and JAK1 and JAK2 kinases in the activation of Stats 1, 3, and 5 by GH
Smit, L. S. (1996) · Molecular Endocrinology · doi:10.1210/me.10.5.519 · Cited by 119
The Jak Kinases Differentially Associate with the and (Accessory Factor) Chains of the Interferon Receptor to Form a Functional Receptor Unit Capable of Activating STAT Transcription Factors (*)
Sakatsume, M., Igarashi, K., Winestock, K., Garotta, G., Larner, A., & Finbloom, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.29.17528 · Cited by 118
Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene
Ackrill, A. M., Foster, G. R., Laxton, C. D., et al. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.16.4387 · Cited by 118
Interferons and interleukin 6 suppress phosphorylation of the retinoblastoma protein in growth-sensitive hematopoietic cells.
Resnitzky, D., Tiefenbrun, N., Berissi, H., & Kimchi, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.402 · Cited by 118
Identification of 69‐kd and 100‐kd forms of 2‐5A synthetase in interferon‐treated human cells by specific monoclonal antibodies.
Hovanessian, A. G., Laurent, A. G., Chebath, J., et al. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb02364.x · Cited by 116
Isolation of DAP3, a Novel Mediator of Interferon-γ-induced Cell Death
Kissil, J. L., Deiss, L. P., Bayewitch, M. L., Raveh, T., Khaspekov, G. L., & Kimchi, A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27932 · Cited by 116
Different Relative Activities of Human Cell-Derived Interferon-α Subtypes: IFN-α8 Has Very High Antiviral Potency
Foster, G. R., RODRIGUES, O., Ghouze, F., et al. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.1027 · Cited by 115
A Bipartite Model of 2-5A-dependent RNase L
Dong, B., & Silverman, R. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.35.22236 · Cited by 114
Self-citation
Targeting RNA for degradation with a (2'-5')oligoadenylate-antisense chimera.
Torrence, P. F., Maitra, R. K., Lesiak, K. B., et al. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1300 · Cited by 113
Interferon-γ-dependent Nuclear Import of Stat1 Is Mediated by the GTPase Activity of Ran/TC4
Sekimoto, T., Nakajima, K., Tachibana, T., Hirano, T., & Yoneda, Y. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.49.31017 · Cited by 113
A Nuclear Tyrosine Phosphatase Downregulates Interferon-Induced Gene Expression
David, M., Grimley, P. M., Finbloom, D. S., & Larner, A. C. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7515 · Cited by 110
The activation of major histocompatibility complex class I genes by interferon regulatory factor-1 (IRF-1)
Chang, C., Hammer, J., Loh, J. E., Fodor, W. L., & Flavell, R. (1992) · Immunogenetics · doi:10.1007/bf00179793 · Cited by 109
Beta Interferon and Oncostatin M Activate Raf-1 and Mitogen-Activated Protein Kinase through a JAK1-Dependent Pathway
Stancato, L. F., Sakatsume, M., David, M., Dent, P., Dong, F., Petricoin, E. F., Krolewski, J. J., Silvennoinen, O., Saharinen, P., Pierce, J. H., et al. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3833 · Cited by 106
IFNα induces the expression of the cyclin-dependent kinase inhibitor p21 in human prostate cancer cells
Hobeika, A. C., Subramaniam, P. S., & Johnson, H. M. (1997) · Oncogene · doi:10.1038/sj.onc.1200939 · Cited by 106
Differences in Interferon α and β Signaling
Platanias, L. C., Shahab Uddin, M. S., Domanski, P. J., & Colamonici, O. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.39.23630 · Cited by 105
Identification of an Interferon-γ Receptor α Chain Sequence Required for JAK-1 Binding
Kaplan, D. H., Greenlund, A. C., Tanner, J. W., Shaw, A. S., & Schreiber, R. D. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.1.9 · Cited by 105
Self-citation
The molecular chaperone hsp40 regulates the activity of P58 IPK , the cellular inhibitor of PKR
Melville, M. W., Hansen, W. J., Freeman, B., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.97 · Cited by 104
Interferon-gamma induces receptor dimerization in solution and on cells.
Greenlund, A. C., Schreiber, R. D., Goeddel, D. V., & Pennica, D. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46817-7 · Cited by 101
Self-citation
Transcription Stimulation of the Fas-encoding Gene by Nuclear Factor for Interleukin-6 Expression upon Influenza Virus Infection
Wada, N., Matsumura, M., Ohba, Y., Kobayashi, N., Takizawa, T., & Nakanishi, Y. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.18007 · Cited by 101
The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains.
Marié, I. J., & Hovanessian, A. G. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50182-x · Cited by 100
The SH2 Domain-containing Tyrosine Phosphatase PTP1D Is Required for Interferon α/β-induced Gene Expression
David, M., Zhou, G., Pine, R. I., Dixon, J. E., & Larner, A. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.15862 · Cited by 99
Regulation of IFN‐α/β genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN‐α/β
Harada, H., Matsumoto, M., Sato, M., Kashiwazaki, Y., Kimura, T., Kitagawa, M., Yokochi, T., Tan, R. S., Takasugi, T., Kadokawa, Y., et al. (1996) · Genes to Cells · doi:10.1046/j.1365-2443.1996.870287.x · Cited by 97
Self-citation
Antiproliferative and antiviral activities of human leukocyte interferons
EVINGER, M. J. Q., Rubinstein, M., & Pestka, S. (1981) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(81)90195-8 · Cited by 97
Mx Transgenic Mice — Animal Models of Health
Arnheiter, H., Frese, M., Kambadur, R., Meier, E., & Haller, O. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-85208-4_8 · Cited by 95
Reflections on STAT3, STAT5, and STAT6 as fat STATs.
Darnell, J. E., Jr. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6221 · Cited by 95
Roles of Protein-tyrosine Phosphatases in Stat1α-mediated Cell Signaling
Haque, S. J., Flati, V., Deb, A., & Williams, B. R. G. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25709 · Cited by 95
Self-citation
Cloning, sequencing, and expression of two murine 2‘-5‘-oligoadenylate synthetases. Structure-function relationships
Ghosh, S. K., Kusari, J., Bandyopadhyay, S. K., Samanta, H. K., Kumar, R., & Sen, G. C. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98615-1 · Cited by 94
Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain.
Marsters, S. A., Pennica, D., Bach, E. A., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5401 · Cited by 94
Intracellular signalling: Putting JAKs on the kinase MAP
Winston, L. A., & Hunter, T. R. (1996) · Current Biology · doi:10.1016/s0960-9822(09)00445-x · Cited by 93
Interruption of cytokine networks by poxviruses: lessons from myxoma virus
McFadden, G., Graham, K., Ellison, K., et al. (1995) · Journal of Leukocyte Biology · doi:10.1002/jlb.57.5.731 · Cited by 93
Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK
Takahashi-Tezuka, M., Hibi, M., Fujitani, Y., Fukada, T., Yamaguchi, T., & Hirano, T. (1997) · Oncogene · doi:10.1038/sj.onc.1201071 · Cited by 91
The Human Type I Interferon Receptor
Croze, E., Russell-Harde, D., Wagner, T. C., et al. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33165 · Cited by 91
In Vitro Activation of a Transcription Factor by Gamma Interferon Requires a Membrane-Associated Tyrosine Kinase and Is Mimicked by Vanadate
Igarashi, K., David, M., Larner, A. C., & Finbloom, D. S. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3984 · Cited by 90
Inhibition of Human Parainfluenza Virus-3 Replication by Interferon and Human MxA
Zhao, H. L., De, B. P., Das, T., & Banerjee, A. K. (1996) · Virology · doi:10.1006/viro.1996.0321 · Cited by 90
Tissue-specific targeting of gytokine unresponsiveness in transgenic mice
Dighe, A. S., Campbell, D., Hsieh, C., Clarke, S., Greaves, D. R., Gordon, S., MURPHY, K. M. M., & Schreiber, R. D. (1995) · Immunity · doi:10.1016/1074-7613(95)90136-1 · Cited by 90
Self-citation
Interferon alpha induces the expression of retinoblastoma gene product in human Burkitt lymphoma Daudi cells: role in growth regulation.
Kumar, R., & Atlas, I. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.14.6599 · Cited by 89
Other Kinases Can Substitute for Jak2 in Signal Transduction by Interferon-γ
Kotenko, S. V., Izotova, L. S., Pollack, B. P., Muthukumaran, G., Paukku, K., Silvennoinen, O., Ihle, J. N., & Pestka, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.29.17174 · Cited by 88
Intracellular Tyrosine Residues of the Human Growth Hormone Receptor Are Not Required for the Signaling of Proliferation or Jak-STAT Activation
Wang, Y.-D., Wong, K., & Wood, W. I. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7021 · Cited by 86
Restoration of interferon responses of adenovirus E1A-expressing HT1080 cell lines by overexpression of p48 protein
Leonard, G. T., & Sen, G. C. (1997) · Journal of Virology · doi:10.1128/jvi.71.7.5095-5101.1997 · Cited by 86
Environmental signals influencing expression of the IFN-gamma receptor on human T cells control whether IFN-gamma promotes proliferation or apoptosis.
Novelli, F., Pierro, F. D., di Celle, P. F., Bertini, S., Affaticati, P., Garotta, G., & Forni, G. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.2.496 · Cited by 85
Interferons, Mx Genes, and Resistance to Influenza Virus
Horisberger, M. A. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/152.4_pt_2.s67 · Cited by 85
The role of the dsRNA-activated kinase, PKR, in signal transduction
Williams, B. (1995) · Seminars in Virology · doi:10.1006/smvy.1995.0024 · Cited by 84
Self-citation
Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.
Perez, C., Coeffier, E., Moreau-Gachelin, F., Wietzerbin, J., & Benech, P. D. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.8.5023 · Cited by 84
Adenovirus early region 1A modulation of interferon antiviral activity
Anderson, K., & Fennie, E. H. (1987) · Journal of Virology · doi:10.1128/jvi.61.3.787-795.1987 · Cited by 83
Interferon‐γ arrests proliferation and causes apoptosis in stromal cell/interleukin‐7‐dependent normal murine pre‐B cell lines and clones in vitro, but does not induce differentiation to surface immunoglobulin‐positive B cells
Grawunder, U., Melchers, F., & Rolink, A. G. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230237 · Cited by 82
Function of the Mouse Mx1 Protein Is Inhibited by Overexpression of the PB2 Protein of Influenza Virus
Stranden, A., Staeheli, P., & Pavlovic, J. (1993) · Virology · doi:10.1006/viro.1993.1639 · Cited by 81
Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKR
Mundschau, L. J., & Faller, D. V. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.7.3100 · Cited by 80
Mx-dependent resistance to influenza viruses is induced by mouse interferons α and β but not γ
Staeheli, P., Horisberger, M. A., & Haller, O. (1984) · Virology · doi:10.1016/0042-6822(84)90050-3 · Cited by 80
Vesicular stomatitis virus transcription inhibited by purified MxA protein
Schwemmle, M., Weining, K. C., Richter, M. F., et al. (1995) · Virology · doi:10.1016/s0042-6822(95)80071-9 · Cited by 80
Identification and characterization of an interferon (IFN)-stimulated response element-IFN-stimulated gene factor 3-independent signaling pathway for IFN-alpha.
Haque, S. J., & Williams, B. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32200-7 · Cited by 77
Self-citation
Constitutive nuclear localization of Janus kinases 1 and 2.
Lobie, P. E., Ronsin, B., Silvennoinen, O., et al. (1996) · Endocrinology · doi:10.1210/endo.137.9.8756581 · Cited by 77
Stoichiometry of interaction between interferon γ and its receptor
Fountoulakis, M., Zulauf, M., Lustig, A., et al. (1992) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1992.tb17248.x · Cited by 76
Targeting RNA decay with 2′,5′ oligoadenylate-antisense in respiratory syncytial virus-infected cells
Cirino, N. M., Li, G., Xiao, W., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.5.1937 · Cited by 76
Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells.
Hovanessian, A. G., Svab, J., Marié, I. J., et al. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68878-7 · Cited by 75
Inducible Expression of the 2-5A Synthetase/RNase L System Results in Inhibition of Vaccinia Virus Replication
Díaz‐Guerra, M., Rivas, C., & Estéban, M. (1997) · Virology · doi:10.1006/viro.1996.8294 · Cited by 73
Two cis-DNA Elements Involved in Myeloid-Cell-Specific Expression and Gamma Interferon (IFN-γ) Activation of the Human High-Affinity Fcγ Receptor Gene: a Novel IFN Regulatory Mechanism
Perez, C., Wietzerbin, J., & Benech, P. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.4.2182 · Cited by 73
Transcription factors induced by interferons α and γ
Imam, A., Ackrill, A. M., Dale, T. C., Kerr, I. M., & Stark, G. R. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.22.6573 · Cited by 72
Self-citation
Structure of mouse Mx1 protein. Molecular assembly and GTP-dependent conformational change
Nakayama, M., Yazaki, K., Kusano, A., Nagata, K., Hanai, N., & Ishihama, A. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82434-6 · Cited by 71
Interferon-induced MxA Protein.
Richter, M. F., Schwemmle, M., Herrmann, C., Wittinghofer, A., & Staeheli, P. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13512 · Cited by 71
Elongation mechanism and substrate specificity of 2',5'-oligoadenylate synthetase.
Justesen, J., Ferbus, D., & THANG, M. N. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.8.4618 · Cited by 70
Interferons and interleukin-6 suppress the DNA-binding activity of E2F in growth-sensitive hematopoietic cells.
Melamed, D., Tiefenbrun, N., Yarden, A., et al. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5255 · Cited by 70
Virus proteins that bind cytokines, chemokines or interferons
Smith, G. L. (1996) · Current Opinion in Immunology · doi:10.1016/s0952-7915(96)80032-x · Cited by 69
Double-stranded RNA-dependent Protein Kinase Mediates c-Myc Suppression Induced by Type I Interferons
Raveh, T. B., Hovanessian, A. G., MEURS, E. F., Sonenberg, N., & Kimchi, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.41.25479 · Cited by 68
Activation of the Double‐Stranded‐RNA‐Activated Protein Kinase and Induction of Vascular Cell Adhesion Molecule‐1 by Poly (I) · Poly (C) in Endothelial Cells
Offermann, M. K., Zimring, J. C., Mellits, K. H., Hagan, M. K., Shaw, R. N., Medford, R. M., Mathews, M. B., Goodbourn, S., & Jagus, R. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.tb20777.x · Cited by 67
A Base Substitution within the GTPase-associated Domain of Mammalian 28 S Ribosomal RNA Causes High Thiostrepton Accessibility
Uchiumi, T., Wada, A., & Kominami, R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.50.29889 · Cited by 66
The Epstein-Barr virus encoded cytokine viral interleukin-10 enhances transformation of human B lymphocytes.
Stuart, A. D., Stewart, J. P., Arrand, J. R., et al. (1995) · PubMed · Cited by 66
Virus-mediated inhibition of the ppp(A2′p)n A system and its prevention by interferon
CAYLEY, P. J., Knight, M., & Kerr, I. M. (1982) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(82)90647-7 · Cited by 64
Self-citation
69‐kDa and 100‐kDa Isoforms of Interferon‐Induced (2′‐5′)Oligoadenylate Synthetase Exhibit Differential Catalytic Parameters
Marié, I., Blanco, J., Rebouillat, D., & Hovanessian, A. G. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.t01-1-00558.x · Cited by 63
Interferon augments PML and PML/RAR alpha expression in normal myeloid and acute promyelocytic cells and cooperates with all-trans retinoic acid to induce maturation of a retinoid-resistant promyelocytic cell line
Nason-Burchenal, K., Gandini, D., Botto, M., et al. (1996) · Blood · doi:10.1182/blood.v88.10.3926.bloodjournal88103926 · Cited by 63
Stoichiometry of 2′,5′-Oligoadenylate-induced Dimerization of Ribonuclease L
Cole, J. L., Carroll, S. S., & Kuo, L. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.3979 · Cited by 62
Virus-induced cell death in plants expressing the mammalian 2′,5′ oligoadenylate system
Ogawa, T., Hori, T., & Ishida, I. (1996) · Nature Biotechnology · doi:10.1038/nbt1196-1566 · Cited by 61
Cleavage of Oligoribonucleotides by the 2′,5′-Oligoadenylate- dependent Ribonuclease L
Carroll, S. S., Chen, E., Viscount, T., Geib, J., Sardana, M. K., Gehman, J. D., & Kuo, L. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4988 · Cited by 61
Interferon‐alpha‐induced phosphorylation and activation of cytosolic phospholipase A2 is required for the formation of interferon‐stimulated gene factor three.
Flati, V., Haque, S. J., & Williams, B. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00501.x · Cited by 60
Self-citation
A mammalian 2-5A system functions as an antiviral pathway in transgenic plants.
Mitra, A., Higgins, D. W., Langenberg, W. G., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6780 · Cited by 58
Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes
Swaminathan, S., Huneycutt, B. S., Reiss, C. S., et al. (1992) · Journal of Virology · doi:10.1128/jvi.66.8.5133-5136.1992 · Cited by 57
IFN-γ induces a p91/Stat1 α-related transcription factor with distinct activation and binding properties
Guyer, N. B., Severns, C. W., Wong, P., Feghali, C. A., & Wright, T. M. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.7.3472 · Cited by 55
Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos
Conway, G. C., Margoliath, A., Wong-Madden, S., Roberts, R. J., & Gilbert, W. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.7.3082 · Cited by 53
Synthesis, Characterisation and Biological Significance of (2′‐5′)Oiigoadenylate Derivatives of NAD+, ADP‐Ribose and Adenosine(5′)Tetraphosph0(5′)Adenosine
CAYLEY, P. J., & Kerr, I. M. (1982) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1982.tb06481.x · Cited by 52
Self-citation
The Short Form of the Interferon α/β Receptor Chain 2 Acts as a Dominant Negative for Type I Interferon Action
Pfeffer, L. M., Basu, L., Pfeffer, S. R., Yang, C. H., Murti, A., Russell-Harde, D., & Croze, E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11002 · Cited by 51
Oncostatin M induces association of Grb2 with Janus kinase JAK2 in multiple myeloma cells.
Chauhan, D., Kharbanda, S. M., Ogata, A., Urashima, M., Frank, D. A., Malik, N., Kufe, D. W., & Anderson, K. C. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1801 · Cited by 50
Partial Inhibition of Vesicular Stomatitis Virus by the Interferon-Induced Human 9-27 Protein
Alber, D., & Staeheli, P. (1996) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1996.16.375 · Cited by 46
Inhibition of Alpha Interferon but Not Gamma Interferon Signal Transduction by Phorbol Esters Is Mediated by a Tyrosine Phosphatase
Petricoin, E. F., David, M., Igarashi, K., Benjamin, C. D., Ling, L. E., Goelz, S. E., Finbloom, D. S., & Larner, A. C. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1419 · Cited by 44
Interaction of p59fynwith Interferon-Activated Jak Kinases
Shahab Uddin, M. S., Sher, D. A., Alsayed, Y. M., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6741 · Cited by 44
Mx1 but Not MxA Confers Resistance against Tick-Borne Dhori Virus in Mice
Thimme, R., Frese, M., Kochs, G., et al. (1995) · Virology · doi:10.1006/viro.1995.1404 · Cited by 44
The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin κ Gene
Koromilas, A. E., Cantin, C., Craig, A. W., Jagus, R., Hiscott, J. B., & Sonenberg, N. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25426 · Cited by 44
Modified subcellular localization of interferon-induced p68 kinase during encephalomyocarditis virus infection
Dubois, M.-F., & Hovanessian, A. G. (1990) · Virology · doi:10.1016/0042-6822(90)90126-c · Cited by 42
Reconstitution of a High Affinity Binding Site for Type I Interferons
Russell-Harde, D., Pu, H., Betts, M., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.44.26033 · Cited by 42
Interferon induction of gene expression through the Jak–Stat pathway
Levy, D. E. (1995) · Seminars in Virology · doi:10.1006/smvy.1995.0023 · Cited by 41
The murine 2-5A synthetase locus: three distinct transcripts from two linked genes
Ruthertord, M. N., Kumar, A., Nissim, A., Chebath, J., & Williams, B. R. G. (1991) · Nucleic Acids Research · doi:10.1093/nar/19.8.1917 · Cited by 38
Self-citation
Enhancement by retinoic acid and dibutyryl cyclic adenosine 3':5'-monophosphate of the differentiation and gene expression of human neuroblastoma cells induced by interferon.
Higuchi, T., Hannigan, G. E., Malkin, D. M., Yeger, H., & Williams, B. R. G. (1991) · PubMed · Cited by 36
Self-citation
Protein phosphorylation in cell growth regulation
Clemens, M. J. (1996) · Cited by 35
Two Molecular Weight Forms of Human 2′,5′-Oligoadenylate Synthetase Have Different Activation Requirements
Ilson, D. H., Torrence, P. F., & Vilček, J. (1986) · Journal of Interferon Research · doi:10.1089/jir.1986.6.5 · Cited by 34
Activation of RNase L by 2′,5′-Oligoadenylates
Cole, J. L., Carroll, S. S., Blue, E. S., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19187 · Cited by 34
Inhibition of apoptotic cell death in B-CLL by interferon gamma correlates with clinical stage.
Rojas, R., Roman, J., Torres, A., et al. (1996) · PubMed · Cited by 33
The vav proto‐oncogene product (p95vav) interacts with the Tyk‐2 protein tyrosine kinase
Shahab Uddin, M. S., Sweet, M., Colamonici, O. R., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00023-9 · Cited by 33
The IL-4-induced tyrosine phosphorylation of the insulin receptor substrate is dependent on JAK1 expression in human fibrosarcoma cells
Wang, H. Y., Zamorano, J., Yoerkie, J. L., Paul, W. E., & Keegan, A. D. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.3.1037 · Cited by 32
Interaction of thec-cblProto-oncogene Product with the Tyk-2 Protein Tyrosine Kinase
Shahab Uddin, M. S., Gardziola, C., Dangat, A., Yi, T., & Platanias, L. C. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1259 · Cited by 31
Nomenclature of the Human Interferon Genes a
Dı́az, M. O., Bohlander, S. K., & Allen, G. F. G. (1993) · Journal of Interferon Research · doi:10.1089/jir.1993.13.243 · Cited by 27
Viruses Launch their Own 'Star Wars'
Barinaga, M. (1992) · Science · doi:10.1126/science.1334571 · Cited by 25
Activation of RNase L by 2′,5′-Oligoadenylates
Carroll, S. S., Cole, J. L., Viscount, T., et al. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19193 · Cited by 25
Modulation of interferon signaling in human fibroblasts by phorbol esters.
Petricoin, E. F., Hackett, R. H., Akai, H., et al. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4486 · Cited by 24
Ap3A and Ap4A are primers for oligoadenylate synthesis catalyzed by interferon‐inducible 2–5A synthetase1
Turpaev, K. T., Hartmann, R., Kisselev, L. L., et al. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00365-7 · Cited by 23
Dimerization of a chimeric CD4-interferon-alpha receptor reconstitutes the signaling events preceding STAT phosphorylation.
Krishnan, K., Yan, H., Jt, L., et al. (1996) · PubMed · Cited by 23
Simian Virus 40 Large-T Bypasses the Translational Block Imposed by the Phosphorylation of eIF-2α
Swaminathan, S., Rajan, P., Савинова, О. В., Jagus, R., & Thimmapaya, B. (1996) · Virology · doi:10.1006/viro.1996.0255 · Cited by 22
Transcriptional Regulation in the Interferon System
Sen, G. C., & Ransohoff, R. M. (1997) · Cited by 21
Occurrence of 2-5A and RNA degradation in the chick oviduct during rapid estrogen withdrawal
Cohrs, R. J., Goswami, B. B., & Sharma, O. K. (1988) · Biochemistry · doi:10.1021/bi00409a019 · Cited by 19
Analysis of 2′,5′-oligoadenylates in cells and tissues
Reid, T. R., Hersh, C. L., Kerr, I. M., et al. (1984) · Analytical Biochemistry · doi:10.1016/0003-2697(84)90315-4 · Cited by 17
Self-citation
Specific Binding of the ETS-Domain Protein to the Interferon-Stimulated Response Element
Rutherford, M., Kumar, A., Haque, S., Ghysdael, J., & Williams, B. R. G. (1997) · Journal of Interferon and Cytokine Research · doi:10.1089/jir.1997.17.1 · Cited by 15
Self-citation
INDUCTION, PURIFICATION, AND PROPERTIES OF 2′5′-OLIGOADENYLATE SYNTHETASE
Ball, L. A., & White, C. N. (1979) · Elsevier eBooks · doi:10.1016/b978-0-12-417580-8.50032-0 · Cited by 13
The interferon-induced enzyme 2–5A synthetase adenylates tRNA
Justesen, J., Worm-Leonhard, H., Ferbus, D., et al. (1985) · Biochimie · doi:10.1016/s0300-9084(85)80207-8 · Cited by 10
Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms
Perea, S. E., López-Ocejo, O., von Gabain, A., et al. (1997) · International Journal of Oncology · doi:10.3892/ijo.11.1.169 · Cited by 9
(2′‐5′)An‐dependent endoribonuclease: Enzyme levels are regulated by IFNβ, IFNγ, and cell culture conditions
Floyd-Smith, G. (1988) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240380103 · Cited by 9

Flagged first, then by citations

Research works printed but not linked: 12

Leaman DW, 1998, Prog. Mol. Subcell. Biol.
Krishnan K, 1996, Oncogene, 13, 125
10.1073/pnas.92.12.5645 · DOI
10.1128/MCB.13.1.588 · DOI · Paper page
Vilcek J, Sen GC. 1996. InFields Virology, ed. BN Fields, DM Knipe, PM Howley, pp. 375–400. Philadelphia: Lippincott-Raven. 3rd ed.
Arnheiter H, 1996, Curr. Top. Microbiol. Immunol., 206, 119
Shen Y, 1995, Curr. Biol., 5, 105
Stuart AD, 1995, Oncogene, 11, 1711
Higuchi T, 1991, Cancer Res., 51, 3958
Rojas R, 1996, Leukemia, 10, 1782
Wang XY, 1995, Blood, 86, 608
Novick D, 1996, Eur. Cytokine Netw., 7, 523

Sorted by citations

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
STATs in cancer inflammation and immunity: a leading role for STAT3
Yu, H., Pardoll, D., & Jove, R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2734 · Cited by 4,383
Interferon-γ: an overview of signals, mechanisms and functions
Schroder, K., Hertzog, P. J., Ravasi, T., & Hume, D. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0603252 · Cited by 4,120
A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing
Landgraf, P., Rusu, M., Sheridan, R., Sewer, A., Iovino, N., Aravin, A., Pfeffer, S., Rice, A., Kamphorst, A. O., Landthaler, M., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.040 · Cited by 3,626

See all 3,932

Authors: Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D.
Affiliations: Cleveland Clinic (US)
ORCID: Stark, George R.
Williams, Bryan R. G.
Silverman, Robert H.
Schreiber, Robert D.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 1998-06
Volume: 67
Issue: 1
Pages: 227-264
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev.biochem.67.1.227
OpenAlex: W2103565638
Cited by: 3,932
References: 322
Citations by year: 2026: 23 · 2025: 22 · 2024: 63 · 2023: 56 · 2022: 53 · 2021: 69 · 2020: 71 · 2019: 73 · 2018: 63 · 2017: 67 · 2016: 78 · 2015: 102 · 2014: 131 · 2013: 130 · 2012: 151
FWCI: 15.02
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Keywords: interferon, interferon signaling, Janus tyrosine kinases, signal transducer and activator of transcription, tyrosine phosphorylation, antiviral response, cell growth inhibition, interferon-induced proteins, immunomodulation
MeSH terms: Antiviral Agents, Interferons, Signal Transduction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

HOW CELLS RESPOND TO INTERFERONS

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks