The DOI matches its Crossref record; 322 of the 322 references it cites were found in a registry or an index.
HOW CELLS RESPOND TO INTERFERONS
Abstract
Interferons play key roles in mediating antiviral and antigrowth responses and in modulating immune response. The main signaling pathways are rapid and direct. They involve tyrosine phosphorylation and activation of signal transducers and activators of transcription factors by Janus tyrosine kinases at the cell membrane, followed by release of signal transducers and activators of transcription and their migration to the nucleus, where they induce the expression of the many gene products that determine the responses. Ancillary pathways are also activated by the interferons, but their effects on cell physiology are less clear. The Janus kinases and signal transducers and activators of transcription, and many of the interferon-induced proteins, play important alternative roles in cells, raising interesting questions as to how the responses to the interferons intersect with more general aspects of cellular physiology and how the specificity of cytokine responses is maintained.
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“The TELmediated repression may be an example of negative regulation acting at the level of transcription, which may be particularly important for ISRE-carrying genes that are normally stimulated by IFN𝛂 / 𝛃 (47).”
From Gamma Interferon Triggers Interaction between ICSBP (IRF-8) and TEL, Recruiting the Histone Deacetylase HDAC3 to the Interferon-Responsive Element (2002) · cites this paper as [47]
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“IL-12 governs production of IFNg in natural killer (NK) cells and CD4 1 T cells.”
From Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid Cells (2002) · cites this paper as [43]
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Metadata
- Authors
- Stark, G. R., Kerr, I. M., Williams, B. R. G., Silverman, R. H., & Schreiber, R. D.
- Affiliations
- Cleveland Clinic (US)
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 1998-06
- Volume
- 67
- Issue
- 1
- Pages
- 227-264
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2103565638
- Cited by
- 3,932
- References
- 322
- Citations by year
- 2026: 23 · 2025: 22 · 2024: 63 · 2023: 56 · 2022: 53 · 2021: 69 · 2020: 71 · 2019: 73 · 2018: 63 · 2017: 67 · 2016: 78 · 2015: 102 · 2014: 131 · 2013: 130 · 2012: 151
- FWCI
- 15.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Keywords
- interferon, interferon signaling, Janus tyrosine kinases, signal transducer and activator of transcription, tyrosine phosphorylation, antiviral response, cell growth inhibition, interferon-induced proteins, immunomodulation
- MeSH terms
- Antiviral Agents, Interferons, Signal Transduction
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