HOW CELLS RESPOND TO INTERFERONS

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Functional diversity of helper T lymphocytes

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NITRIC OXIDE AND MACROPHAGE FUNCTION

MacMicking, J. D., Xie, Q. W., & Nathan, C. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.323 · Cited by 4,245

STATs and Gene Regulation

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Virus interference. I. the interferon

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Development of T H 1 CD4 + T Cells Through IL-12 Produced by Listeria -Induced Macrophages

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CELLULAR RESPONSES TO INTERFERON-γ

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Inflammation. Basic principles and clinical correlates

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Interleukin 12: A Proinflammatory Cytokine with Immunoregulatory Functions That Bridge Innate Resistance and Antisen-Specific Adaptive Immunity

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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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A family of cytokine-inducible inhibitors of signalling

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Multiple defects of immune cell function in mice with disrupted interferon-gamma genes.

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Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

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Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

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INTERFERONS AND THEIR ACTIONS

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TRANSCRIPTIONAL RESPONSES TO POLYPEPTIDE LIGANDS: The JAK-STAT Pathway

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Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway

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The cell biology of macrophage activation.

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Immune Response in Mice that Lack the Interferon-γ Receptor

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Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

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A new protein containing an SH2 domain that inhibits JAK kinases

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STATs: Signal Transducers and Activators of Transcription

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Interleukin-6 family of cytokines and gp130.

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The Molecular Cell Biology of Interferon-Gamma and Its Receptor

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Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

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Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN- γ production

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A Mutation in the Interferon-γ –Receptor Gene and Susceptibility to Mycobacterial Infection

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Identification and Characterization of an IκB Kinase

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Activation of Interferon-γ Inducing Factor Mediated by Interleukin-1β Converting Enzyme

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THE IFNγ RECEPTOR:A Paradigm for Cytokine Receptor Signaling

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Structure and function of a new STAT-induced STAT inhibitor

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Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

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Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

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Viral inhibition of inflammation: Cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme

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Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes

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Jaks and Stats in signaling by the cytokine receptor superfamily.

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The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response

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Molecular Mimicry of Human Cytokine and Cytokine Response Pathway Genes by KSHV

Moore, P. S., Boshoff, C., Weiss, R. A., & Chang, Y. (1996) · Science · doi:10.1126/science.274.5293.1739 · Cited by 900

Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor

Schindler, C., Shuai, K., Prezioso, V. R., & Darnell, J. E. (1992) · Science · doi:10.1126/science.1496401 · Cited by 899

Interferon-γ –Receptor Deficiency in an Infant with Fatal Bacille Calmette–Guérin Infection

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Requirement for Transcription Factor IRF-1 in NO Synthase Induction in Macrophages

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Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

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Dynamin self-assembles into rings suggesting a mechanism for coated vesicle budding

Hinshaw, J. E., & Schmid, S. L. (1995) · Nature · doi:10.1038/374190a0 · Cited by 824

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

Gale, M., Korth, M. J., Tang, N., Tan, S., Hopkins, D. A., Dever, T. E., Polyak, S. J., Gretch, D. R., & Katze, M. G. (1997) · Virology · doi:10.1006/viro.1997.8493 · Cited by 810

Inhibition of Viral Replication by Interferon-γ-Induced Nitric Oxide Synthase

Karupiah, G., Xie, Q. W., Buller, R. M. L., Nathan, C., Duarte, C. J., & MacMicking, J. D. (1993) · Science · doi:10.1126/science.7690156 · Cited by 810

A Single Phosphotyrosine Residue of Stat91 Required for Gene Activation by Interferon-γ

Shuai, K., Stark, G. R., Kerr, L. M., & Darnell, J. E. (1993) · Science · doi:10.1126/science.7690989 · Cited by 802

Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development

Russell, S. M., Tayebi, N., Nakajima, H., Riedy, M. C., Roberts, J. L., Aman, M. J., Migone, T., Noguchi, M., Markert, M. L., Buckley, R. H., et al. (1995) · Science · doi:10.1126/science.270.5237.797 · Cited by 801

pppA2'p5'A2'p5'A: an inhibitor of protein synthesis synthesized with an enzyme fraction from interferon-treated cells.

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Interleukin 6 and its receptor: ten years later

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Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein.

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Tubular membrane invaginations coated by dynamin rings are induced by GTP-γS in nerve terminals

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Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

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Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters

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The human interferon $alpha;/$beta; receptor: Characterization and molecular cloning

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Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development

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Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

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Defective Lymphoid Development in Mice Lacking Jak3

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Deficient signaling in mice devoid of double‐stranded RNA‐dependent protein kinase.

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Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

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ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

York, I. A., & Rock, K. L. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.369 · Cited by 604

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death.Preprint

Deiss, L. P., Feinstein, E., Berissi, H., Cohen, O., & Kimchi, A. (1995) · Genes & Development · doi:10.1101/gad.9.1.15 · Cited by 591

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

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Interferon action and apoptosis are defective in mice devoid of 2′,5′‐oligoadenylate‐dependent RNase L

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Requirement of endogenous interferon-gamma production for resolution of Listeria monocytogenes infection.

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Requirement for MAP Kinase (ERK2) Activity in Interferon α- and Interferon β-Stimulated Gene Expression Through STAT Proteins

David, M., Petricoin, E., Benjamin, C. D., Pine, R. I., Weber, M. J., & Larner, A. C. (1995) · Science · doi:10.1126/science.7569900 · Cited by 543

A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain.Preprint

Horvath, C. M., Wen, Z., & Darnell, J. E., Jr. (1995) · Genes & Development · doi:10.1101/gad.9.8.984 · Cited by 537

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

Koromilas, A. E., Roy, S., Barber, G. N., Katze, M. G., & Sonenberg, N. (1992) · Science · doi:10.1126/science.1382315 · Cited by 532

Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

Zhou, A. (1993) · Cell · doi:10.1016/0092-8674(93)90403-d · Cited by 515

Defective TNF-α-Induced Apoptosis in STAT1-Null Cells Due to Low Constitutive Levels of Caspases

Kumar, A., Commane, M., Flickinger, T. W., Horvath, C. M., & Stark, G. R. (1997) · Science · doi:10.1126/science.278.5343.1630 · Cited by 508

Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α

Bhattacharya, S., Eckner, R., Grossman, S., Oldread, E., Arany, Z., D'Andrea, A., & Livingston, D. M. (1996) · Nature · doi:10.1038/383344a0 · Cited by 493

Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species soecificity

Symons, J. A., Alcamı́, A., & Smith, G. L. (1995) · Cell · doi:10.1016/0092-8674(95)90076-4 · Cited by 491

Two contact regions between Stat1 and CBP/p300 in interferon γ signaling

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REGULATION OF MHC CLASS II GENES: Lessons from a Disease

Mach, B., Steimle, V., Martínez-Soria, E., & Reith, W. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.301 · Cited by 487

Cooperative DNA Binding and Sequence-Selective Recognition Conferred by the STAT Amino-Terminal Domain

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Regulation of Interleukin 12 p40 Expression through an NF-κB Half-Site

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Cathepsin D protease mediates programmed cell death induced by interferon‐gamma, Fas/APO‐1 and TNF‐alpha.

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Ligand‐induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

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Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

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GAS Elements: A Few Nucleotides with a Major Impact on Cytokine-Induced Gene Expression

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An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

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Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

Heim, M. H., Kerr, L. M., Stark, G. R., & Darnell, J. E., Jr. (1995) · Science · doi:10.1126/science.7871432 · Cited by 430

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

MEURS, E. F., GALABRU, J., Barber, G. N., Katze, M. G., & Hovanessian, A. G. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.1.232 · Cited by 427

DAP‐kinase is a Ca2+/calmodulin‐dependent, cytoskeletal‐associated protein kinase, with cell death‐inducing functions that depend on its catalytic activity

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Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300

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Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon‐alpha and ‐gamma signal transduction pathways.

Müller, M., Laxton, C., Briscoe, J., Schindler, C., Improta, T., Darnell, J. E., Stark, G. R., & Kerr, I. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb06106.x · Cited by 411

Developmental commitment to the Th2 lineage by extinction of IL-12 signaling

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Regulation of Interferon-γ-Activated STAT1 by the Ubiquitin-Proteasome Pathway

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DAP kinase links the control of apoptosis to metastasis

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A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

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Virus proteins that counteract host immune defenses

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Use of a Selectable Marker Regulated by Alpha Interferon To Obtain Mutations in the Signaling Pathway

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Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

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An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes

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