The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Apoptosis Signaling
Abstract
▪ Abstract Apoptosis, a physiological process for killing cells, is critical for the normal development and function of multicellular organisms. Abnormalities in cell death control can contribute to a variety of diseases, including cancer, autoimmunity, and degenerative disorders. Signaling for apoptosis occurs through multiple independent pathways that are initiated either from triggering events within the cell or from outside the cell, for instance, by ligation of death receptors. All apoptosis signaling pathways converge on a common machinery of cell destruction that is activated by a family of cysteine proteases (caspases) that cleave proteins at aspartate residues. Dismantling and removal of doomed cells is accomplished by proteolysis of vital cellular constituents, DNA degradation, and phagocytosis by neighboring cells. This article reviews current knowledge of apoptosis signaling, lists several pressing questions, and presents a novel model to explain the biochemical and functional interactions between components of the cell death regulatory machinery.
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Citations
Cites
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Self-citationMolecular characterization of mitochondrial apoptosis-inducing factor
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Cited by
The Bcl2 family: regulators of the cellular life-or-death switch
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How does p53 induce apoptosis and how does this relate to p53-mediated tumour suppression
Aubrey, B. J., Kelly, G. L., Janic, A., Herold, M. J., & Strasser, A. (2018) · Cell Death & Differentiation · doi:10.1038/cdd.2017.169 · Cited by 1,395
Self-citationJNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
Lei, K., & Davis, R. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438011100 · Cited by 1,068
Programmed Anuclear Cell Death Delimits Platelet Life Span
Mason, K. D., Carpinelli, M. R., Fletcher, J. I., Collinge, J. E., Hilton, A. A., Ellis, S., Kelly, P. N., Ekert, P. G., Metcalf, D., Roberts, A. W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.037 · Cited by 1,031
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Self-citation
Metadata
- Authors
- Strasser, A., O'Connor, L., & Dixit, V. M.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2000-06
- Volume
- 69
- Issue
- 1
- Pages
- 217-245
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W4239718055
- Cited by
- 1,351
- References
- 10
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
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