The DOI matches its Crossref record; 202 of the 202 references it cites were found in a registry or an index.
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
Abstract
▪ Abstract DNA repair is crucial to the well-being of all organisms from unicellular life forms to humans. A rich tapestry of mechanistic studies on DNA repair has emerged thanks to the recent discovery of Y-family DNA polymerases. Many Y-family members carry out aberrant DNA synthesis—poor replication accuracy, the favored formation of non-Watson-Crick base pairs, efficient mismatch extension, and most importantly, an ability to replicate through DNA damage. This review is devoted primarily to a discussion of Y-family polymerase members that exhibit error-prone behavior. Roles for these remarkable enzymes occur in widely disparate DNA repair pathways, such as UV-induced mutagenesis, adaptive mutation, avoidance of skin cancer, and induction of somatic cell hypermutation of immunoglobulin genes. Individual polymerases engaged in multiple repair pathways pose challenging questions about their roles in targeting and trafficking. Macromolecular assemblies of replication-repair “factories” could enable a cell to handle the complex logistics governing the rapid migration and exchange of polymerases.
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“Translesion synthesis (TLS) polymerases copy past lesions in DNA that block the major replicative polymerases (7)(8)(9)(10)(11).”
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Metadata
- Authors
- Goodman, M. F.
- Affiliations
- University of Southern California (US)
- Corresponding author
- Goodman, Myron F.
- ORCID
- Goodman, Myron F.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2002-06
- Volume
- 71
- Issue
- 1
- Pages
- 17-50
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2142513910
- Cited by
- 727
- References
- 202
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 6 · 2023: 9 · 2022: 8 · 2021: 6 · 2020: 14 · 2019: 13 · 2018: 17 · 2017: 18 · 2016: 14 · 2015: 17 · 2014: 30 · 2013: 36 · 2012: 36
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5p01ag017179-03, 5r01gm042554-13)
- National Institute on Aging (AG17179)
- National Institute of General Medical Sciences (GM 42554, GM 21422)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Y-family DNA polymerases, error-prone DNA replication, DNA repair, mismatch extension, UV mutagenesis, adaptive mutation, skin cancer prevention, immunoglobulin genes
- MeSH terms
- Animals, DNA Damage, DNA-Directed DNA Polymerase, DNA Repair, DNA Replication, Escherichia coli, Eukaryotic Cells, Humans, Models, Genetic, Mutation, Nuclear Proteins, SOS Response, Genetics, Protein Structure, Tertiary, Somatic Hypermutation, Immunoglobulin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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