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COPPER-ZINC SUPEROXIDE DISMUTASE AND AMYOTROPHIC LATERAL SCLEROSIS

Valentine, Joan Selverstone, Doucette, Peter A., Zittin Potter, Soshanna·2005·Annual Review of Biochemistry
DOI 10.1146/annurev.biochem.72.121801.161647
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Abstract

▪ Abstract Copper-zinc superoxide dismutase (CuZnSOD, SOD1 protein) is an abundant copper- and zinc-containing protein that is present in the cytosol, nucleus, peroxisomes, and mitochondrial intermembrane space of human cells. Its primary function is to act as an antioxidant enzyme, lowering the steady-state concentration of superoxide, but when mutated, it can also cause disease. Over 100 different mutations have been identified in the sod1 genes of patients diagnosed with the familial form of amyotrophic lateral sclerosis (fALS). These mutations result in a highly diverse group of mutant proteins, some of them very similar to and others enormously different from wild-type SOD1. Despite their differences in properties, each member of this diverse set of mutant proteins causes the same clinical disease, presenting a challenge in formulating hypotheses as to what causes SOD1-associated fALS. In this review, we draw together and summarize information from many laboratories about the characteristics of the individual mutant SOD1 proteins in vivo and in vitro in the hope that it will aid investigators in their search for the cause(s) of SOD1-associated fALS.

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Research works printed but not linked: 133

  1. 10.1056/NEJM200105313442207 · DOI · Paper page
  2. 10.1146/annurev.neuro.27.070203.144244 · DOI · Paper page
  3. 10.1126/science.8209258 · DOI · Paper page
  4. 10.1007/s004010050650 · DOI · Paper page
  5. 10.1038/ng0596-43 · DOI · Paper page
  6. 10.1073/pnas.91.17.8292 · DOI · Paper page
  7. 10.1073/pnas.92.7.3024 · DOI · Paper page
  8. 10.1073/pnas.032539299 · DOI · Paper page
  9. 10.1523/JNEUROSCI.21-23-09246.2001 · DOI · Paper page
  10. 10.1046/j.1440-1789.2001.00361.x · DOI
  11. 10.1002/jcb.10782 · DOI
  12. 10.1074/jbc.M105395200 · DOI · Paper page
  13. Sturtz LA, 2001, J. Biol. Chem., 276, 38084, 10.1074/jbc.M105296200 · DOI · Paper page
  14. 10.1016/S0898-8838(08)60026-4 · DOI
  15. 10.1073/pnas.0305143101 · DOI · Paper page
  16. 10.1021/bi982284u · DOI · Paper page
  17. 10.1142/9781848160699_0010 · DOI
  18. Lyons TJ, 1999, Met. Ions Biol. Syst., 36, 125
  19. 10.1074/jbc.R000006200 · DOI · Paper page
  20. 10.1016/S0065-3233(02)60054-3 · DOI
  21. 10.1038/sj.emboj.7600276 · DOI · Paper page
  22. 10.1073/pnas.0730423100 · DOI · Paper page
  23. 10.1002/jnr.10328 · DOI · Paper page
  24. 10.1016/S0896-6273(01)00177-5 · DOI · Paper page
  25. 10.1038/418291a · DOI · Paper page
  26. 10.1002/(SICI)1097-010X(199809/10)282:1/2<32::AID-JEZ7>3.0.CO;2-O · doi:10.1002/(sici)1097-010x(199809/10)282:1/2<32::aid-jez7>3.0.co;2-o
  27. 10.1016/j.pneurobio.2004.05.004 · DOI
  28. 10.1006/nbdi.2001.0471 · DOI · Paper page
  29. 10.1006/nbdi.2002.0498 · DOI · Paper page
  30. 10.1073/pnas.220417997 · DOI · Paper page
  31. 10.1038/35097565 · DOI · Paper page
  32. 10.1080/14660820310011700 · DOI · Paper page
  33. 10.1038/ng0595-61 · DOI · Paper page
  34. 10.1006/nbdi.2002.0508 · DOI
  35. 10.1074/jbc.M112087200 · DOI · Paper page
  36. 10.1074/jbc.M112088200 · DOI · Paper page
  37. 10.1074/jbc.M210419200 · DOI · Paper page
  38. 10.1007/s00775-003-0447-6 · DOI
  39. 10.1002/ana.410410212 · DOI · Paper page
  40. 10.1159/000191315 · DOI
  41. 10.1038/378342a0 · DOI
  42. 10.1136/jnnp.63.6.814a · doi:10.1136/jnnp.63.6.814a
  43. 10.1016/S0022-510X(99)00216-6 · DOI
  44. 10.1002/humu.9081 · DOI
  45. 10.1016/0022-510X(95)00314-R · DOI
  46. 10.1212/WNL.48.3.746 · DOI
  47. 10.1023/A:1020217818245 · DOI
  48. 10.1073/pnas.95.11.6361 · DOI · Paper page
  49. 10.1073/pnas.91.21.9906 · DOI
  50. 10.1093/hmg/8.8.1451 · DOI · Paper page
  51. 10.1074/jbc.271.45.28331 · DOI
  52. 10.1074/jbc.M305435200 · DOI
  53. 10.1074/jbc.271.45.28335 · DOI
  54. 10.1023/A:1018364130807 · doi:10.1023/a:1018364130807
  55. 10.1074/jbc.M304296200 · DOI · Paper page
  56. 10.1093/hmg/ddg312 · DOI · Paper page
  57. 10.1097/00002281-200311000-00008 · DOI
  58. Robberecht W, 2000, J. Neurol., 247, 2
  59. 10.1021/ja015953r · DOI
  60. 10.1016/j.freeradbiomed.2004.06.006 · DOI
  61. 10.1080/1071576021000016454 · DOI
  62. Uchida K, 1994, J. Biol. Chem., 269, 2405, 10.1016/S0021-9258(17)41960-0 · DOI · Paper page
  63. 10.1074/jbc.M300484200 · DOI
  64. 10.1006/bbrc.1998.8182 · DOI
  65. 10.1016/j.jbiotec.2004.01.002 · doi:10.1016/j.jbiotec.2004.01.002
  66. 10.1016/S0006-291X(03)00809-X · DOI · Paper page
  67. Salo DC, 1990, J. Biol. Chem., 265, 11919, 10.1016/S0021-9258(19)38488-1 · DOI · Paper page
  68. 10.1159/000065693 · DOI
  69. 10.1002/ana.410440510 · DOI · Paper page
  70. 10.1046/j.1471-4159.1998.71052041.x · DOI · Paper page
  71. 10.1016/S0891-5849(02)01080-8 · DOI
  72. 10.1046/j.1471-4159.2003.01841.x · DOI
  73. 10.1093/hmg/10.19.2013 · DOI
  74. 10.1016/S0022-510X(96)00031-7 · DOI
  75. 10.1074/jbc.270.7.3234 · DOI
  76. 10.1016/0304-3940(96)12701-4 · doi:10.1016/0304-3940(96)12701-4
  77. 10.1016/S0014-5793(96)01362-2 · doi:10.1016/s0014-5793(96)01362-2
  78. 10.1046/j.1471-4159.2002.01211.x · DOI · Paper page
  79. 10.1074/jbc.M206559200 · DOI · Paper page
  80. 10.1186/1471-2202-4-16 · DOI · Paper page
  81. 10.1016/0896-6273(95)90259-7 · DOI · Paper page
  82. 10.1046/j.1471-4159.1997.69020675.x · DOI
  83. McCord JM, 1969, J. Biol. Chem., 244, 6049, 10.1016/S0021-9258(18)63504-5 · DOI · Paper page
  84. 10.1046/j.1471-4159.1997.69051936.x · DOI · Paper page
  85. Lepock JR, 1990, J. Biol. Chem., 265, 21612, 10.1016/S0021-9258(18)45784-5 · DOI
  86. 10.1073/pnas.1237797100 · DOI · Paper page
  87. 10.1016/S0022-2836(02)01090-2 · DOI
  88. 10.1016/S0022-2836(03)00889-1 · DOI · Paper page
  89. 10.1021/bi026704y · DOI
  90. 10.1126/science.271.5248.515 · DOI · Paper page
  91. 10.1074/jbc.275.2.1007 · DOI · Paper page
  92. Rodriguez JA. 2004. Thermal stability, catalytic activity and spectroscopic properties of amyotrophic lateral sclerosis-associated copper-zinc superoxide dismutases. PhD thesis. Univ. Calif., Los Angeles. 244pp.
  93. Doucette PA. 2004. Biophysical studies of human copper-zinc superoxide dismutase and mutants associated with the neurodegenerative disease amyotrophic lateral sclerosis. PhD thesis. Univ. Calif., Los Angeles. 249pp.
  94. Valentine JS, Pantoliano MW. 1981. Protein-Metal Ion Interactions in Cuprozinc Protein(Superoxide Dismutase), pp.291–358. New York: Wiley
  95. Beem KM, 1974, J. Biol. Chem., 249, 7298, 10.1016/S0021-9258(19)42105-4 · doi:10.1016/s0021-9258(19)42105-4
  96. 10.1073/pnas.93.22.12240 · DOI · Paper page
  97. Schulz GE, Schirmer RH. 1979. Principles of Protein Structure. New York/Heidelberg: Springer-Verlag. 314pp. · DOI · Paper page
  98. 10.1002/pro.5560070302 · DOI
  99. 10.1038/nsb935 · DOI · Paper page
  100. 10.1074/jbc.M406021200 · DOI · Paper page
  101. 10.1016/j.jmb.2003.09.069 · DOI
  102. 10.1006/jmbi.1999.2681 · DOI
  103. 10.1073/pnas.87.13.5006 · DOI · Paper page
  104. Cabelli DE, 1989, J. Biol. Chem., 264, 9967, 10.1016/S0021-9258(18)81754-9 · DOI
  105. 10.1021/bi00695a011 · DOI · Paper page
  106. Yim MB, 1993, J. Biol. Chem., 268, 4099, 10.1016/S0021-9258(18)53585-7 · DOI · Paper page
  107. 10.1021/ic00264a014 · doi:10.1021/ic00264a014
  108. 10.1016/j.abb.2003.11.015 · DOI
  109. 10.1074/jbc.274.3.1226 · DOI
  110. 10.1016/j.freeradbiomed.2004.03.006 · DOI
  111. 10.1073/pnas.0307635100 · DOI
  112. 10.1021/ja9927467 · DOI · Paper page
  113. 10.1074/jbc.M302051200 · DOI
  114. 10.1073/pnas.93.12.5709 · DOI · Paper page
  115. 10.1074/jbc.272.14.8861 · DOI
  116. 10.1016/S0891-5849(01)00778-X · DOI
  117. 10.1006/jmbi.1999.2610 · DOI
  118. 10.1021/bi010655s · DOI
  119. 10.1016/S0022-2836(03)00355-3 · DOI · Paper page
  120. 10.1073/pnas.052706099 · DOI · Paper page
  121. 10.1016/0014-5793(78)80917-X · DOI
  122. 10.1016/0006-291X(78)91557-7 · DOI
  123. 10.3181/00379727-131-34110 · DOI · Paper page
  124. 10.1006/jsbi.2000.4221 · DOI · Paper page
  125. 10.1016/j.bbrc.2003.11.008 · DOI
  126. 10.1021/bi00403a017 · DOI
  127. Senoo Y, 1988, Acta Med. Okayama, 42, 169
  128. 10.1021/bi00590a005 · DOI
  129. Forman HJ, 1973, J. Biol. Chem., 248, 2645, 10.1016/S0021-9258(19)44055-6 · DOI · Paper page
  130. 10.1073/pnas.262527099 · DOI · Paper page
  131. 10.1021/bi000846f · DOI
  132. 10.1006/abbi.1997.0298 · doi:10.1006/abbi.1997.0298
  133. 10.1074/jbc.M409744200 · DOI · Paper page

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Metadata

Authors
Valentine, J. S., Doucette, P. A., & Zittin Potter, S.
Venue
Annual Review of Biochemistry
Publisher
Annual Reviews
Published
2005-06-01
Volume
74
Issue
1
Pages
563-593
ISSN
  • 0066-4154 (ISSN-L)
  • 1545-4509
DOI
10.1146/annurev.biochem.72.121801.161647
OpenAlex
W2105442888
Cited by
785
References
7
FWCI
1.82
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: COPPER-ZINC SUPEROXIDE DISMUTASE AND AMYOTROPHIC LATERAL SCLEROSIS. https://app.cochat.ai/papers/10.1146/annurev.biochem.72.121801.161647
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Valentine, J. S., Doucette, P. A., & Zittin Potter, S. (2005). COPPER-ZINC SUPEROXIDE DISMUTASE AND AMYOTROPHIC LATERAL SCLEROSIS. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.72.121801.161647

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