The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY
Abstract
▪ Abstract The underlying basis for the accuracy of protein synthesis has been the subject of over four decades of investigation. Recent biochemical and structural data make it possible to understand at least in outline the structural basis for tRNA selection, in which codon recognition by cognate tRNA results in the hydrolysis of GTP by EF-Tu over 75 Å away. The ribosome recognizes the geometry of codon-anticodon base pairing at the first two positions but monitors the third, or wobble position, less stringently. Part of the additional binding energy of cognate tRNA is used to induce conformational changes in the ribosome that stabilize a transition state for GTP hydrolysis by EF-Tu and subsequently result in accelerated accommodation of tRNA into the peptidyl transferase center. The transition state for GTP hydrolysis is characterized, among other things, by a distorted tRNA. This picture explains a large body of data on the effect of antibiotics and mutations on translational fidelity. However, many fundamental questions remain, such as the mechanism of activation of GTP hydrolysis by EF-Tu, and the relationship between decoding and frameshifting.
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Cites
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Self-citationCrystal structure of the ribosome at 5.5 Å resolution
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Cited by
Ribosome-targeting antibiotics and mechanisms of bacterial resistance
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What recent ribosome structures have revealed about the mechanism of translation
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Self-citationtRNA’s Wobble Decoding of the Genome: 40 Years of Modification
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The evolutionary consequences of erroneous protein synthesis
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Fidelity at the Molecular Level: Lessons from Protein Synthesis
Zaher, H. S., & Green, R. (2009) · Cell · doi:10.1016/j.cell.2009.01.036 · Cited by 386
Metadata
- Authors
- Ogle, J. M., & Ramakrishnan, V.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2005-06-01
- Volume
- 74
- Issue
- 1
- Pages
- 129-177
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2117430673
- Cited by
- 588
- References
- 16
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ogle, J. M., & Ramakrishnan, V. (2005). STRUCTURAL INSIGHTS INTO TRANSLATIONAL FIDELITY. Annual Review of Biochemistry. https://doi.org/10.1146/annurev.biochem.74.061903.155440
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