The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
How Does Synaptotagmin Trigger Neurotransmitter Release?
Abstract
Neurotransmitter release at synapses involves a highly specialized form of membrane fusion that is triggered by Ca 2+ions and is optimized for speed. These observations were established decades ago, but only recently have the molecular mechanisms that underlie this process begun to come into view. Here, we summarize findings obtained from genetically modified neurons and neuroendocrine cells, as well as from reconstituted systems, which are beginning to reveal the molecular mechanism by which Ca 2+—acting on the synaptic vesicle (SV) protein synaptotagmin I (syt)—triggers rapid exocytosis. This work sheds light not only on presynaptic aspects of synaptic transmission, but also on the fundamental problem of membrane fusion, which has remained a puzzle that has yet to be solved in any biological system.
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Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,547
Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution
Sutton, R. B., Fasshauer, D., Jahn, R., & Brunger, A. T. (1998) · Nature · doi:10.1038/26412 · Cited by 2,417
Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse
Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C. (1994) · Cell · doi:10.1016/0092-8674(94)90556-8 · Cited by 1,483
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding.
Davletov, B. A., & Südhof, T. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)74326-9 · Cited by 480
Munc18-1 Promotes Large Dense-Core Vesicle Docking
Voets, T., Toonen, R. F., Brian, E. C., de Wit, H., Moser, T., Rettig, J., Südhof, T. C., Neher, E., & Verhage, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00391-9 · Cited by 396
Xu, J., Mashimo, T., & Südhof, T. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.004 · Cited by 336
Araç, D., Chen, X., Khant, H. A., Ubach, J., Ludtke, S. J., Kikkawa, M., Johnson, A. E., Chiu, W., Südhof, T. C., & Rizo, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1056 · Cited by 256
Pang, Z. P., Shin, O.-H., Meyer, A. C., Rosenmund, C., & Südhof, T. C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3804-06.2006 · Cited by 113
Conserved Prefusion Protein Assembly in Regulated Exocytosis
Rickman, C., Jiménez, J. L., Graham, M. E., Archer, D. A., Soloviev, M., Burgoyne, R. D., & Davletov, B. (2006) · Molecular Biology of the Cell · doi:10.1091/mbc.e05-07-0620 · Cited by 74
Cited by
Rizo, J., & Rosenmund, C. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1450 · Cited by 538
Nanodomain coupling between Ca2+ channels and sensors of exocytosis at fast mammalian synapses
Eggermann, E., Bucurenciu, I., Goswami, S. P., & Jonas, P. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3125 · Cited by 500
The mechanisms and functions of synaptic facilitation.
Jackman, S. L., & Regehr, W. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.047 · Cited by 489
Botulinum Neurotoxin: A Marvel of Protein Design
Montal, M. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.051908.125345 · Cited by 411
The Membrane Fusion Enigma: SNAREs, Sec1/Munc18 Proteins, and Their Accomplices—Guilty as Charged?
Rizo, J., & Südhof, T. C. (2012) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155818 · Cited by 386
Metadata
- Authors
- Chapman, E. R.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2008-06-01
- Volume
- 77
- Issue
- 1
- Pages
- 615-641
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2126412071
- Cited by
- 544
- References
- 9
- FWCI
- 2.36
- Type
- journal article
- Language
- en
- Open access
- closed
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