The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Stem and Progenitor Cells: Origins, Phenotypes, Lineage Commitments, and Transdifferentiations
Abstract
▪ Abstract Multipotent stem cells are clonal cells that self-renew as well as differentiate to regenerate adult tissues. Whereas stem cells and their fates are known by unique genetic marker studies, the fate and function of these cells are best studied by their prospective isolation. This review is about the properties of various highly purified tissue-specific multipotent stem cells and purified oligolineage progenitors. We contend that unless the stem or progenitor cells in question have been purified to near homogeneity, one cannot know whether their generation of expected (or unexpected) progeny is a property of a known cell type. It is interesting that in the hematopoietic system the only long-term self-renewing cells in the stem and progenitors pool are the hematopoietic stem cells. This fact is discussed in the context of normal and leukemic hematopoiesis.
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“By utilizing BrdU as a tracing molecule, it was observed that exercise not only increased proliferation of the progenitor cells in the subgranular zone, but also increased their survival rate as they differentiated and matured (van Praag et al., 1999; Seri et al., 2001; for reviews of neural progenitors and lineage progression see Weissman et al., 2001; Seri et al., 2004; Göritz and Frisén, 2012).”
From Exercise-Mediated Neurogenesis in the Hippocampus via BDNF (2018) · cites this paper as Weissman et al., 2001
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Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Bonnet, D. A., & Dick, J. E. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,197
Neurogenesis in the adult human hippocampus
Eriksson, P. S., Perfilieva, E., Björk-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998) · Nature Medicine · doi:10.1038/3305 · Cited by 6,369
Self-citationBone marrow cells regenerate infarcted myocardium
Orlic, D., Kajstura, J., Chimenti, S., Jakoniuk, I., Anderson, S. M., Li, B., Pickel, J. M., McKay, R. D. G., Nadal‐Ginard, B., Bodine, D. M., et al. (2001) · Nature · doi:10.1038/35070587 · Cited by 5,149
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Self-citationReynolds, B. A., & Weiss, S. (1992) · Science · doi:10.1126/science.1553558 · Cited by 4,482
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells1
Till, J. E., & McCulloch, E. A. (2010) · Radiation Research · doi:10.1667/rrxx28.1 · Cited by 4,036
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
Till, J. E., & McCulloch, E. A. (1961) · Radiation Research · doi:10.2307/3570892 · Cited by 3,848
More hippocampal neurons in adult mice living in an enriched environment
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1997) · Nature · doi:10.1038/386493a0 · Cited by 3,586
Self-citationPurification and Characterization of Mouse Hematopoietic Stem Cells
Spangrude, G. J., Heimfeld, S., & Weissman, I. L. (1988) · Science · doi:10.1126/science.2898810 · Cited by 2,908
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Research works printed but not linked: 3
- 10.1182/blood.V93.9.2755 · DOI
- Shizuru JA, 1996, Biol. Blood Marrow Transplant., 2, 3
- Tsukamoto A, Weissman IL, Chen B, DiGiusto D, Baum C, et al. 1995. Phenotypic and functional analysis of hematopoietic stem cells in mouse and human. InHematopoietic Stem Cells: Biology and Therapeutic Applications, ed. D Levitt, R Mertelsmann, pp. 85–124. New York: Dekker
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Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Beltrami, A. P., Barlucchi, L., Torella, D., Baker, M., Limana, F., Chimenti, S., Kasahara, H., Rota, M., Musso, E., Urbanek, K., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00687-1 · Cited by 3,528
A Stem Cell Molecular Signature
Ivanova, N. B., Dimos, J. T., Schaniel, C., Hackney, J. A., Moore, K. A., & Lemischka, I. R. (2002) · Science · doi:10.1126/science.1073823 · Cited by 1,543
Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L., & Fuchs, E. (2004) · Cell · doi:10.1016/j.cell.2004.08.012 · Cited by 1,428
Milestones of neuronal development in the adult hippocampus
Kempermann, G., Jessberger, S., Steiner, B., & Kronenberg, G. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.013 · Cited by 1,460
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Ito, K., Hirao, A., Arai, F., Takubo, K., Matsuoka, S., Miyamoto, K., Ohmura, M., Naka, K., Hosokawa, K., Ikeda, Y., et al. (2006) · Nature Medicine · doi:10.1038/nm1388 · Cited by 1,362
Metadata
- Authors
- Weissman, I. L., Anderson, D. J., & Gage, F.
- Affiliations
- Stanford Medicine (US)
- California Institute of Technology (US)
- Salk Institute for Biological Studies (US)
- Corresponding author
- Gage, Fred
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2001-11
- Volume
- 17
- Issue
- 1
- Pages
- 387-403
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2172294715
- Cited by
- 948
- References
- 100
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 15 · 2023: 10 · 2022: 28 · 2021: 27 · 2020: 38 · 2019: 25 · 2018: 28 · 2017: 39 · 2016: 29 · 2015: 46 · 2014: 43 · 2013: 41 · 2012: 45
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- CaltechAUTHORS (California Institute of Technology) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- multipotent stem cells, progenitor cells, self-renewal, tissue regeneration, lineage commitment, transdifferentiation, hematopoietic stem cells, hematopoiesis, cell purification
- MeSH terms
- Animals, Cell Differentiation, Cell Separation, Cell Transformation, Neoplastic, Clone Cells, Hematopoiesis, Hematopoietic Stem Cells, Humans, Nervous System, Phenotype, Regeneration, Stem Cells, Cell Lineage
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