Cited by 658Axon Guidance and Neuronal SignalingNeuroscience and Neuropharmacology ResearchProtein Kinase Regulation and GTPase Signaling

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Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity

Luo, Liqun·2002·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev.cellbio.18.031802.150501

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Abstract

▪ Abstract The actin cytoskeleton plays a major role in morphological development of neurons and in structural changes of adult neurons. This article reviews the myriad functions of actin and myosin in axon initiation, growth, guidance and branching, in morphogenesis of dendrites and dendritic spines, in synapse formation and stability, and in axon and dendrite retraction. Evidence is presented that signaling pathways involving the Rho family of small GTPases are key regulators of actin polymerization and myosin function in the context of different aspects of neuronal morphogenesis. These studies support an emerging theme: Different aspects of neuronal morphogenesis may involve regulation of common core signaling pathways, in particular the Rho GTPases.

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Authors: Luo, L.
Affiliations: Stanford University (US)
Corresponding author: Luo, Liqun
ORCID: Luo, Liqun
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2002-11
Volume: 18
Issue: 1
Pages: 601-635
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev.cellbio.18.031802.150501
OpenAlex: W2148013477
Cited by: 658
References: 151
Citations by year: 2026: 10 · 2025: 16 · 2024: 24 · 2023: 10 · 2022: 14 · 2021: 28 · 2020: 18 · 2019: 18 · 2018: 20 · 2017: 26 · 2016: 32 · 2015: 23 · 2014: 22 · 2013: 40 · 2012: 30
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords: actin cytoskeleton, neuronal morphogenesis, structural plasticity, axon guidance, dendrite formation, dendritic spines, synaptogenesis, axon retraction, dendrite retraction, myosin, Rho GTPases, actin polymerization, signaling pathways
MeSH terms: Actins, Animals, Cell Differentiation, Cytoskeleton, Dendrites, Humans, Nervous System, Neuronal Plasticity, Synapses, Growth Cones, rho GTP-Binding Proteins

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Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity

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