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Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Abstract
▪ Abstract The actin cytoskeleton plays a major role in morphological development of neurons and in structural changes of adult neurons. This article reviews the myriad functions of actin and myosin in axon initiation, growth, guidance and branching, in morphogenesis of dendrites and dendritic spines, in synapse formation and stability, and in axon and dendrite retraction. Evidence is presented that signaling pathways involving the Rho family of small GTPases are key regulators of actin polymerization and myosin function in the context of different aspects of neuronal morphogenesis. These studies support an emerging theme: Different aspects of neuronal morphogenesis may involve regulation of common core signaling pathways, in particular the Rho GTPases.
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“The actin cytoskeleton plays a key role in shaping dendritic spines and is critically important for numerous processes that contribute to the plasticity of synaptic function (Matus, 2000; Hering and Sheng, 2001; Luo, 2002; Ethell and Pasquale, 2005; Hotulainen and Hoogenraad, 2010).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Luo, 2002
In the citing paper
“Actin cytoskeletal dynamics have a key role in the establishment and maintenance of both dendritic arborizations and spines, and are also critical for the structural alterations in spine shape important for cellular forms of synaptic plasticity, such as long-term potentiation and long-term depression.20, 21, 22, 23”
From The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (2014) · cites this paper as [20]
In the citing paper
“The Rho small GTPases (particularly RhoA, Rac1, Cdc42) are regulators of the actin cytoskeleton that have a profound influence on spine morphogenesis (Luo, 2002; Newey et al., 2005).”
From The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning (2017) · cites this paper as Luo, 2002
In the citing paper
“In this regard, the observed changes in pathways related to cytoskeletal regulation and axon guidance in the trigeminal ganglion could potentially explain the observed changes in infraorbital nerve structure, as both are essential for structural plasticity33,34.”
From A deep-learning framework reveals whole-body perturbations at cell level (2026) · cites this paper as [33]
Citations
Cites
Rho GTPases and the Actin Cytoskeleton
Hall, A. (1998) · Science · doi:10.1126/science.279.5350.509 · Cited by 6,138
Nobes, C. D., & Hall, A. (1995) · Cell · doi:10.1016/0092-8674(95)90370-4 · Cited by 4,414
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
Ridley, A. J., Paterson, H. F., Johnston, C. L., Diekmann, D., & Hall, A. (1992) · Cell · doi:10.1016/0092-8674(92)90164-8 · Cited by 3,616
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T., Morishita, T., Tamakawa, H., Yamagami, K., Inui, J., Maekawa, M., et al. (1997) · Nature · doi:10.1038/40187 · Cited by 2,862
Rho GTPases and signaling networksPreprint
Aelst, L. V., & D’Souza‐Schorey, C. (1997) · Genes & Development · doi:10.1101/gad.11.18.2295 · Cited by 2,358
Phosphorylation and Activation of Myosin by Rho-associated Kinase (Rho-kinase)
Amano, M., Ito, M., Kimura, K., Fukata, Y., Chihara, K., Nakano, T., Matsuura, Y., & Kaibuchi, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20246 · Cited by 2,009
The establishment of polarity by hippocampal neurons in culture.
Dotti, C., Sullivan, C., & Banker, G. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-04-01454.1988 · Cited by 1,862
Neurotrophins as synaptic modulators
Poo, M.-M. (2001) · Nature Reviews Neuroscience · doi:10.1038/35049004 · Cited by 1,775
Signaling from Rho to the Actin Cytoskeleton Through Protein Kinases ROCK and LIM-kinase
Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K., & Narumiya, S. (1999) · Science · doi:10.1126/science.285.5429.895 · Cited by 1,640
Research works printed but not linked: 3
- 10.1083/jcb.152.1.1 · DOI
- Luo L, 1996, Perspect. Dev. Neurobiol., 4, 199
- Sin W-C, 2001, Nature.
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Lamprecht, R., & LeDoux, J. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1301 · Cited by 1,010
Pape, H.-C., & Pare, D. (2010) · Physiological Reviews · doi:10.1152/physrev.00037.2009 · Cited by 994
The role of the Rho GTPases in neuronal developmentPreprint
Govek, E., Newey, S. E., & Aelst, L. V. (2005) · Genes & Development · doi:10.1101/gad.1256405 · Cited by 1,030
Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance
Dent, E. W., & Gertler, F. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00633-0 · Cited by 922
AXON RETRACTION AND DEGENERATION IN DEVELOPMENT AND DISEASE
Luo, L., & O’Leary, D. D. M. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135632 · Cited by 859
Self-citationActin in dendritic spines: connecting dynamics to function
Hotulainen, P., & Hoogenraad, C. C. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003008 · Cited by 815
Huber, A. B., Kolodkin, A. L., Ginty, D. D., & Cloutier, J. (2003) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.010302.081139 · Cited by 720
Branching out: mechanisms of dendritic arborization
Jan, Y.-N., & Jan, L. Y. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2836 · Cited by 693
Rossoll, W., Jablonka, S., Andreassi, C., Kröning, A.-K., Karle, K. N., Monani, U. R., & Sendtner, M. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200304128 · Cited by 637
Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways
Kumar, V., Zhang, M.-X., Swank, M. W., Kunz, J., & Wu, G.-Y. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2284-05.2005 · Cited by 588
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C. (2005) · Nature Neuroscience · doi:10.1038/nn1374 · Cited by 485
The actin cytoskeleton: integrating form and function at the synapse
Dillon, C., & Goda, Y. (2005) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.28.061604.135757 · Cited by 447
Specificity of peripheral nerve regeneration: Interactions at the axon level
Allodi, I., Udina, E., & Navarro, X. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.005 · Cited by 422
Brain-Derived Neurotrophic Factor Is Required for the Maintenance of Cortical Dendrites
Gorski, J. A., Zeiler, S. R., Tamowski, S., & Jones, K. R. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-17-06856.2003 · Cited by 411
Signaling mechanisms and functional roles of cofilin phosphorylation and dephosphorylation
Mizuno, K. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2012.11.001 · Cited by 396
Myosins: Tails (and Heads) of Functional Diversity
Krendel, M., & Mooseker, M. S. (2005) · Physiology · doi:10.1152/physiol.00014.2005 · Cited by 400
Regulation of Dendritic Development by Neuron-Specific Chromatin Remodeling Complexes
Wu, J. I., Lessard, J. A., Olave, I. A., Qiu, Z., Ghosh, A., Graef, I. A., & Crabtree, G. R. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.021 · Cited by 398
Tolias, K. F., Bikoff, J. B., Burette, A., Paradis, S., Harrar, D., Tavazoie, S., Weinberg, R. J., & Greenberg, M. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.024 · Cited by 365
Rho GTPases, dendritic structure, and mental retardation
Newey, S. E., Velamoor, V., Govek, E., & Van Aelst, L. (2005) · Journal of Neurobiology · doi:10.1002/neu.20153 · Cited by 351
Guerrier, S., Coutinho‐Budd, J., Sassa, T., Gresset, A., Jordan, N. V., Chen, K., Jin, W., Frost, A. S., & Polleux, F. (2009) · Cell · doi:10.1016/j.cell.2009.06.047 · Cited by 356
Molecular mechanisms of dendritic spine development and remodeling
Ethell, I. M., & Pasquale, E. B. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.02.003 · Cited by 367
Gu, Y., Fu, Y., Dowd, P. E., Li, S., Vernoud, V., Gilroy, S., & Yang, Z. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200409140 · Cited by 342
Structural and synaptic plasticity in stress-related disorders
Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334
Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J.-L., & Giangrande, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00354-4 · Cited by 316
The Control of Dendrite Development
Jan, Y. N., & Jan, L. Y. (2003) · Neuron · doi:10.1016/s0896-6273(03)00631-7 · Cited by 311
MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation
Yu, J., Chung, K.-H., Deo, M., Thompson, R. C., & Turner, D. L. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.06.002 · Cited by 321
Neuronal Polarity and Trafficking
Horton, A. C., & Ehlers, M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00629-9 · Cited by 301
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Goda, Y., & Davis, G. W. (2003) · Neuron · doi:10.1016/s0896-6273(03)00608-1 · Cited by 305
Dent, E. W., Barnes, A. M., Tang, F., & Kalil, K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4963-03.2004 · Cited by 290
Signalling mechanisms mediating neuronal responses to guidance cues
Guan, K., & Rao, Y. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1254 · Cited by 287
Wnt signaling in neural circuit assembly
Salinas, P. C., & Zou, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125649 · Cited by 274
The Growing Role of mTOR in Neuronal Development and Plasticity
Jaworski, J., & Sheng, M. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:3:205 · Cited by 239
Effects of Sleep and Wake on Oligodendrocytes and Their Precursors
Bellesi, M., Pfister‐Genskow, M., Maret, S., Keleş, S., Tononi, G., & Cirelli, C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.5102-12.2013 · Cited by 263
Usher syndrome: molecular links of pathogenesis, proteins and pathways
Kremer, H., van Wijk, E., Märker, T., Uwe Wolfrum, B., & Roepman, R. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl205 · Cited by 255
Tashiro, A., & Yuste, R. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.04.001 · Cited by 265
RhoA/ROCK regulation of neuritogenesis via profilin IIa–mediated control of actin stability
Silva, J. S. D., Medina, M., Zuliani, C., Nardo, A. D., Witke, W., & Dotti, C. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200304021 · Cited by 249
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Gaudilliere, B. L., Konishi, Y., de la Iglesia, N., Yao, G.-L., & Bonni, A. (2004) · Neuron · doi:10.1016/s0896-6273(03)00841-9 · Cited by 245
Developmental mechanism of the periodic membrane skeleton in axons
Zhong, G., He, J., Zhou, R., Lorenzo, D. N., Babcock, H. P., Bennett, V., & Zhuang, X. (2014) · eLife · doi:10.7554/elife.04581 · Cited by 246
Ahmad‐Annuar, A., Ciani, L., Simeonidis, I., Herreros, J., Fredj, N. B., Rosso, S. B., Hall, A. C., Brickley, S. G., & Salinas, P. C. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511054 · Cited by 233
Emoto, K., He, Y., Ye, B., Grueber, W. B., Adler, P. N., Jan, L. Y., & Jan, Y.-N. (2004) · Cell · doi:10.1016/j.cell.2004.09.036 · Cited by 235
Rho GTPases and activity-dependent dendrite development
Aelst, L. V., & Cline, H. T. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.05.012 · Cited by 239
The actin cytoskeleton in normal and pathological cell motility
Lambrechts, A., Troys, M. V., & Ampè, C. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.01.024 · Cited by 235
Diverse Modes of Axon Elaboration in the Developing Neocortex
Portera-Cailliau, C., Weimer, R. M., De Paola, V., Caroni, P., & Svoboda, K. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030272 · Cited by 225
Rocca, D. L., Martin, S., Jenkins, E. L., & Hanley, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1688 · Cited by 228
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP‐dependent dendritogenesis
Lee-Hoeflich, S. T., Causing, C. G., Podkowa, M., Zhao, X., Wrana, J. L., & Attisano, L. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600418 · Cited by 220
Ena/VASP Is Required for Neuritogenesis in the Developing Cortex
Kwiatkowski, A. V., Rubinson, D. A., Dent, E. W., van Veen, J. E., Leslie, J. D., Zhang, J., Mebane, L. M., Philippar, U., Pinheiro, E. M., Burds, A. A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.008 · Cited by 222
Wang, H., Lu, F.-M., Jin, I., Udo, H., Kandel, E. R., de Vente, J., Walter, U., Lohmann, S. M., Hawkins, R. D., & Antonova, I. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.011 · Cited by 216
THE NOGO SIGNALING PATHWAY FOR REGENERATION BLOCK
He, Z., & Koprivica, V. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.27.070203.144340 · Cited by 215
Developmental regulation of axon branching in the vertebrate nervous system
Gibson, D. A., & Ma, L. (2010) · Development · doi:10.1242/dev.046441 · Cited by 215
The energetic brain—A review from students to students
Bordone, M. P., Salman, M. M., Titus, H. E., Amini, E., Andersen, J. V., Chakraborti, B., Diuba, A. V., Dubouskaya, T. G., Ehrke, E., Espindola de Freitas, A., et al. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14829 · Cited by 205
“Actin cytoskeleton (re-)modeling underlies neuron morphology and modulates synaptic function and structural plasticity (Luo 2002; Cingolani and Goda 2008), requiring ATP hydrolysis (Wegner 1976; Carlier et al. 1988).”
BackgroundSchreiber, T., Gaßmann, K., Götz, C., Hübenthal, U., Moors, M., Krause, G., Merk, H. F., Nguyen, N.-H., Scanlan, T. S., Abel, J., et al. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901435 · Cited by 203
Control of axonal branching and synapse formation by focal adhesion kinase
Rico, B., Beggs, H. E., Schahin-Reed, D., Kimes, N. E., Schmidt, A., & Reichardt, L. F. (2004) · Nature Neuroscience · doi:10.1038/nn1317 · Cited by 194
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Kalil, K., & Dent, E. W. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.005 · Cited by 196
Meng, J., Meng, Y., Hanna, A., Janus, C., & Jia, Z. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0028-05.2005 · Cited by 202
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Zito, K., Knott, G. W., Shepherd, G. M., Shenolikar, S., & Svoboda, K. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.022 · Cited by 202
Pathania, M., Davenport, E. C., Muir, J., Sheehan, D. F., López-Doménech, G., & Kittler, J. T. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.16 · Cited by 189
Arp2/3 Is a Negative Regulator of Growth Cone Translocation
Strasser, G. A., Rahim, N. A., Mills, K. V., Gertler, F. B., & Lanier, L. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.015 · Cited by 189
He, J., Zhou, R., Wu, Z., Carrasco, M. A., Kurshan, P. T., Farley, J. E., Simon, D. J., Wang, G., Han, B., Hao, J., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1605707113 · Cited by 184
Axon Initial Segment Cytoskeleton: Architecture, Development, and Role in Neuron Polarity
Jones, S. L., & Svitkina, T. (2016) · Neural Plasticity · doi:10.1155/2016/6808293 · Cited by 191
CDKL5, a Protein Associated with Rett Syndrome, Regulates Neuronal Morphogenesis via Rac1 Signaling
Chen, Q., Zhu, Y., Yu, J., Miao, S., Zheng, J., Xu, L., Zhou, Y., Li, D., Zhang, C., Tao, J., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1102-10.2010 · Cited by 181
The axonal cytoskeleton: from organization to function
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Telomere Shortening in Neural Stem Cells Disrupts Neuronal Differentiation and Neuritogenesis
Ferrón, S. R., Marqués-Torrejón, M. Á., Mira, H., Flores, I., Taylor, K., Blasco, M. A., & Fariñas, I. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3836-09.2009 · Cited by 179
Lai, K., & Ip, N. Y. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.08.012 · Cited by 182
Lee, J., Gravel, M., Zhang, R., Thibault, P., & Braun, P. E. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411047 · Cited by 186
Dehmelt, L., Smart, F. M., Ozer, R. S., & Halpain, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-29-09479.2003 · Cited by 172
Coyle, I. P., Koh, Y.-H., Lee, W.-C. M., Slind, J. K., Fergestad, T., Littleton, J. T., & Ganetzky, B. (2004) · Neuron · doi:10.1016/s0896-6273(04)00016-9 · Cited by 168
Shi, Y., Pontrello, C. G., DeFea, K., Reichardt, L. F., & Ethell, I. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4681-08.2009 · Cited by 171
Hernández-Deviez, D. J., Roth, M. G., Casanova, J. E., & Wilson, J. M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-06-0410 · Cited by 162
FMRP interferes with the Rac1 pathway and controls actin cytoskeleton dynamics in murine fibroblasts
Castets, M., Schaeffer, C., Bechara, E., Schenck, A., Khandjian, E. W., Luche, S., Moine, H., Rabilloud, T., Mandel, J.-L., & Bardoni, B. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi077 · Cited by 162
McLennan, Y., Polussa, J., Tassone, F., & Hagerman, R. (2011) · Current Genomics · doi:10.2174/138920211795677886 · Cited by 160
Ball, R. W., Warren-Paquin, M., Tsurudome, K., Liao, E. H., Elazzouzi, F., Cavanagh, C., An, B., Wang, T. T., White, J. H., & Haghighi, A. P. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.011 · Cited by 153
Transmitting on actin: synaptic control of dendritic architecture
Schubert, V., & Dotti, C. G. (2007) · Journal of Cell Science · doi:10.1242/jcs.03337 · Cited by 151
Laub, F., Lei, L., Sumiyoshi, H., Kajimura, D., Dragomir, C. L., Smaldone, S., Puché, A. C., Petros, T. J., Mason, C. A., Parada, L. F., et al. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5699-5711.2005 · Cited by 151
Integrin-Mediated Dendrite Branch Maintenance Requires Abelson (Abl) Family Kinases
Moresco, E. M. Y., Donaldson, S., Williamson, A., & Koleske, A. J. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1432-05.2005 · Cited by 144
Synaptic Wnt signaling—a contributor to major psychiatric disorders?
Okerlund, N. D., & Cheyette, B. N. R. (2011) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-011-9083-6 · Cited by 149
PRPS1 Mutations: Four Distinct Syndromes and Potential Treatment
de Brouwer, A. P. M., van Bokhoven, H., Nabuurs, S. B., ARTS, W. F. M., Christodoulou, J., & Duley, J. A. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.02.024 · Cited by 150
Sigoillot, S. M., Iyer, K., Binda, F., González-Calvo, I., Talleur, M., Vodjdani, G., Isope, P., & Selimi, F. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.01.034 · Cited by 144
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Cornell, B., & Toyo‐oka, K. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00318 · Cited by 149
Bowerman, M., Shafey, D., & Kothary, R. (2007) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0024-5 · Cited by 140
Ma, X., Huang, J., Wang, Y., Eipper, B. A., & Mains, R. E. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-33-10593.2003 · Cited by 142
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Scott, E. K., Reuter, J. E., & Luo, L. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-08-03118.2003 · Cited by 134
Self-citationAneuploidy: From a Physiological Mechanism of Variance to Down Syndrome
Dierssen, M., Hérault, Y., & Estivill, X. (2009) · Physiological Reviews · doi:10.1152/physrev.00032.2007 · Cited by 143
Meixner, A., Boldt, K., Troys, M. V., Askenazi, M., Gloeckner, C. J., Bauer, M., Marto, J. A., Ampè, C., Kinkl, N., & Ueffing, M. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.001172 · Cited by 136
Regulation of hippocampal long-term potentiation by p21-activated protein kinase 1 (PAK1)
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Wang, C., Chang, K., Petralia, R. S., Wang, Y., Seabold, G. K., & Wenthold, R. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3799-05.2006 · Cited by 130
Tsubouchi, A., Caldwell, J. C., & Tracey, W. D. (2012) · Current Biology · doi:10.1016/j.cub.2012.09.019 · Cited by 127
Sfakianos, M. K., Eisman, A. S., Gourley, S. L., Bradley, W. D., Scheetz, A. J., Settleman, J. E., Taylor, J. R., Greer, C. A., Williamson, A., & Koleske, A. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0793-07.2007 · Cited by 123
Huang, F., Chotiner, J. K., & Steward, O. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2410-07.2007 · Cited by 127
Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus
Matas-Rico, E., García-Díaz, B., Llebrez-Zayas, P., López-Barroso, D., Santín, L. J., Pedraza, C., Smith‐Fernández, A., Fernández‐Llebrez, P., Téllez, T., Redondo, M., et al. (2008) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2008.07.014 · Cited by 127
Axon Guidance by Growth Cones and Branches: Common Cytoskeletal and Signaling Mechanisms
Dent, E. W., Tang, F., & Kalil, K. (2003) · The Neuroscientist · doi:10.1177/1073858403252683 · Cited by 123
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Lundström, A., Gallio, M., Englund, C., Steneberg, P., Hemphälä, J., Aspenström, P., Keleman, K., Falileeva, L., Dickson, B. J., & Samakovlis, C. (2004) · Genes & Development · doi:10.1101/gad.310204 · Cited by 121
Alfonso, J., Fernández, M. E., Cooper, B. H., Flügge, G., & Frasch, A. C. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504262102 · Cited by 120
Takemoto‐Kimura, S., Ageta‐Ishihara, N., Nonaka, M., Adachi-Morishima, A., Mano, T., Okamura, M., Fujii, H., Fuse, T., Hoshino, M., Suzuki, S., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.021 · Cited by 117
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Beg, A. A., Sommer, J. E., Martin, J. H., & Scheiffele, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.036 · Cited by 115
Metadata
- Authors
- Luo, L.
- Affiliations
- Stanford University (US)
- Corresponding author
- Luo, Liqun
- ORCID
- Luo, Liqun
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2002-11
- Volume
- 18
- Issue
- 1
- Pages
- 601-635
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2148013477
- Cited by
- 658
- References
- 151
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 24 · 2023: 10 · 2022: 14 · 2021: 28 · 2020: 18 · 2019: 18 · 2018: 20 · 2017: 26 · 2016: 32 · 2015: 23 · 2014: 22 · 2013: 40 · 2012: 30
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Cell and Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- actin cytoskeleton, neuronal morphogenesis, structural plasticity, axon guidance, dendrite formation, dendritic spines, synaptogenesis, axon retraction, dendrite retraction, myosin, Rho GTPases, actin polymerization, signaling pathways
- MeSH terms
- Actins, Animals, Cell Differentiation, Cytoskeleton, Dendrites, Humans, Nervous System, Neuronal Plasticity, Synapses, Growth Cones, rho GTP-Binding Proteins
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