The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
DOCOSAHEXAENOIC ACID, FATTY ACID–INTERACTING PROTEINS, AND NEURONAL FUNCTION: Breastmilk and Fish Are Good for You
Abstract
In contrast to other tissues, the nervous system is enriched in the polyunsaturated fatty acids (PUFAs): arachidonic acid (AA, 20:4 n-6) and docosahexaenoic acid (DHA, 22:6 n-3). Despite their abundance in the nervous system, AA and DHA cannot be synthesized de novo by mammals; they, or their precursors, must be ingested from dietary sources and transported to the brain. During late gestation and the early postnatal period, neurodevelopment is exceptionally rapid, and substantial amounts of PUFAs, especially DHA, are critical to ensure neurite outgrowth as well as proper brain and retina development. Here, we review the various functions of DHA in the nervous system, the proteins involved in its internalization and metabolism into phospholipids, and its relationship to several neurological disorders, including Alzheimer's disease and depression.
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Cites
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Cited by
A lipidomic analysis of nonalcoholic fatty liver disease
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Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins
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Metadata
- Authors
- Marszalek, J. R., & Lodish, H. F.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2005-11-01
- Volume
- 21
- Issue
- 1
- Pages
- 633-657
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2098132849
- Cited by
- 270
- References
- 11
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: DOCOSAHEXAENOIC ACID, FATTY ACID–INTERACTING PROTEINS, AND NEURONAL FUNCTION: Breastmilk and Fish Are Good for You. https://app.cochat.ai/papers/10.1146/annurev.cellbio.21.122303.120624
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- Marszalek, J. R., & Lodish, H. F. (2005). DOCOSAHEXAENOIC ACID, FATTY ACID–INTERACTING PROTEINS, AND NEURONAL FUNCTION: Breastmilk and Fish Are Good for You. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev.cellbio.21.122303.120624
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