Deletion of the Mitochondrial Carrier Genes MRS3 andMRS4 Suppresses Mitochondrial Iron Accumulation in a Yeast Frataxin-deficient Strain
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The mitochondrial solute carriers Mrs3p and Mrs4p were originally isolated as multicopy suppressors of intron splicing defects. We show here that MRS4 is co-regulated with the iron regulon genes, and up-regulated in a strain deficient for Yfh1p, the yeast homologue of human frataxin. Using in vivo 55Fe cell radiolabeling we show that in glucose-grown cells mitochondrial iron accumulation is 5-15 times higher in deltaYFH1 than in wild-type strain. However, although in a deltaYFH1deltaMRS3deltaMRS4 strain, the intracellular 55Fe content is extremely high, the mitochondrial iron concentration is decreased to almost wild-type levels. Moreover, deltaYFH1deltaMRS3deltaMRS4 cells grown in high iron media do not lose their mitochondrial genome. Conversely, a deltaYFH1 strain overexpressing MRS4 has an increased mitochondrial iron content and no mitochondrial genome. Therefore, MRS4 is required for mitochondrial iron accumulation in deltaYFH1 cells. Expression of the iron regulon and intracellular 55Fe content are higher in a deltaMRS3deltaMRS4 strain than in the wild type. Nevertheless, the mitochondrial 55Fe content, a balance between iron uptake and exit, is decreased by a factor of two. Moreover, 55Fe incorporation into heme by ferrochelatase is increased in an MRS4-overexpressing strain. The function of MRS4 in iron import into mitochondria is discussed.
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In yeast, frataxin is involved in mitochondrial iron efflux or iron storage.
“In yeast, it was demonstrated that frataxin is involved in mitochondrial iron efflux (252) or iron storage (96, 234).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [96]
Cites
Functional Discovery via a Compendium of Expression Profiles
Hughes, T. R., Marton, M. J., Jones, A. R., Roberts, C. J., Stoughton, R. B., Armour, C. D., Bennett, H. A., Coffey, E. M., Dai, H. A., He, Y. D., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00015-5 · Cited by 2,534 · see citing works
New heterologous modules for classical or PCR‐based gene disruptions in Saccharomyces cerevisiae
Wach, A., Brachat, A., Pöhlmann, R., & Philippsen, P. (1994) · Yeast · doi:10.1002/yea.320101310 · Cited by 2,532 · see citing works
A new efficient gene disruption cassette for repeated use in budding yeast
Güldener, U. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.13.2519 · Cited by 1,657 · see citing works
Regulation of Mitochondrial Iron Accumulation by Yfh1p, a Putative Homolog of Frataxin
Babcock, M., de Silva, D., Oaks, R., Davis-Kaplan, S., Jiralerspong, S., Montermini, L., Pandolfo, M., & Kaplan, J. (1997) · Science · doi:10.1126/science.276.5319.1709 · Cited by 921 · see citing works
Puccio, H., Simon, D., Cossée, M., Criqui-Filipe, P., Tiziano, F., Melki, J., Hindelang, C., Matyas, R., Rustin, P., & Koenig, M. (2001) · Nature Genetics · doi:10.1038/84818 · Cited by 738 · see citing works
The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins
Kispál, G., Csere, P., Prohl, C., & Lill, R. (1999) · The EMBO Journal · doi:10.1093/emboj/18.14.3981 · Cited by 699 · see citing works
Foury, F., & Cazzalini, O. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00734-5 · Cited by 378 · see citing works
Self-citationAFT1: a mediator of iron regulated transcriptional control in Saccharomyces cerevisiae.
Yamaguchi‐Iwai, Y., Dancis, A., & Klausner, R. D. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07106.x · Cited by 358 · see citing works
CCC1 Is a Transporter That Mediates Vacuolar Iron Storage in Yeast
Li, L., Chen, O. S., Ward, D. M., & Kaplan, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103944200 · Cited by 354 · see citing works
The Yeast Frataxin Homologue Mediates Mitochondrial Iron Efflux
Radisky, D. C., Babcock, M. C., & Kaplan, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4497 · Cited by 277 · see citing works
Iron-Dependent Self-Assembly of Recombinant Yeast Frataxin: Implications for Friedreich Ataxia
Adamec, J., Rusnak, F., Owen, W. G., Naylor, S., Benson, L. M., Gacy, A. M., & Isaya, G. (2000) · The American Journal of Human Genetics · doi:10.1086/303056 · Cited by 255 · see citing works
Paulsen, I. T., Sliwinski, M. K., Nelissen, B., Goffeau, A., & Saier, M. H. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00629-2 · Cited by 217 · see citing works
Mühlenhoff, U., & Lill, R. (2000) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00174-2 · Cited by 204 · see citing works
Blaiseau, P.-L., Lesuisse, E., & Camadro, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104987200 · Cited by 193 · see citing works
Mitochondrial Control of Iron Homeostasis
Foury, F., & Talibi, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005804200 · Cited by 176 · see citing works
Self-citationMinh, D. B., Gregáň, J., Jarosch, E., Ragnini‐Wilson, A., & Schweyen, R. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20438 · Cited by 175 · see citing works
Kwast, K. E., Burke, P. V., Staahl, B. T., & Poyton, R. O. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.10.5446 · Cited by 175 · see citing works
Mechanism of Iron Transport to the Site of Heme Synthesis inside Yeast Mitochondria
Lange, H., Kispal, G., & Lill, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.27.18989 · Cited by 170 · see citing works
Li, L., & Kaplan, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.35.22181 · Cited by 168 · see citing works
Iron storage in Saccharomyces cerevisiae
Raguzzi, F., Lesuisse, E., & Crichton, R. R. (1988) · FEBS Letters · doi:10.1016/0014-5793(88)80742-7 · Cited by 164 · see citing works
Three Cell Wall Mannoproteins Facilitate the Uptake of Iron in Saccharomyces cerevisiae
Protchenko, O. V., Ferea, T., Rashford, J., Tiedeman, J., Brown, P. O., Botstein, D., & Philpott, C. C. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m109220200 · Cited by 163 · see citing works
The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly
Huynen, M. A. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.21.2463 · Cited by 157 · see citing works
A second iron-regulatory system in yeast independent of Aft1p
Rutherford, J. C., Jaron, S., Ray, E., Brown, P. O., & Winge, D. R. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261381198 · Cited by 153 · see citing works
Low iron concentration and aconitase deficiency in a yeast frataxin homologue deficient strain
Foury, F. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00961-8 · Cited by 145 · see citing works
Self-citationMéthode d'estimation de la concentration des cytochromes dans les cellules entières de levure
CLAISSE, M. L., Péré-Aubert, G., Clavilier, L., & Słonimski, P. P. (1970) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1970.tb01098.x · Cited by 113 · see citing works
Wiesenberger, G., Link, T. A., von Ahsen, U., Waldherr, M., & Schweyen, R. J. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90608-9 · Cited by 99 · see citing works
Characterization of Two Homologous Yeast Genes That Encode Mitochondrial Iron Transporters
Li, L., & Kaplan, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.45.28485 · Cited by 85 · see citing works
A multitude of suppressors of group II intron-splicing defects in yeast
Waldherr, M., Ragnini‐Wilson, A., Jank, B., Teply, R., Wiesenberger, G., & Schweyen, R. J. (1993) · Current Genetics · doi:10.1007/bf00336780 · Cited by 75 · see citing works
Mitochondrial Mg2+ homeostasis is critical for group II intron splicing in vivoPreprint
Gregáň, J., Kolísek, M., & Schweyen, R. J. (2001) · Genes & Development · doi:10.1101/gad.201301 · Cited by 75 · see citing works
Properties of chemically modified Ni(II)Fe(II) hybrid hemoglobins
Shibayama, N., Morimoto, H., & Kitagawa, T. (1986) · Journal of Molecular Biology · doi:10.1016/0022-2836(86)90368-2 · Cited by 58 · see citing works
Belenkiy, R., Haefele, A., Eisen, M. B., & Wohlrab, H. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00222-4 · Cited by 49 · see citing works
Mitochondrial Iron Metabolism in the Yeast Saccharomyces cerevisiae
Craig, E. A., Voisine, C., & Schilke, B. A. (1999) · Biological Chemistry · doi:10.1515/bc.1999.148 · Cited by 43 · see citing works
Li, F., Nikali, K., Gregáň, J., Leibiger, I. B., Leibiger, B., Schweyen, R. J., Larsson, C., & Suomalainen, A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02319-5 · Cited by 42 · see citing works
Role of the Cytoskeleton in Endocytosis of the Yeast Maltose Transporter
Peñalver, É., OJEDA, L., MORENO, E., & Lagunas, R. (1997) · Yeast · doi:10.1002/(sici)1097-0061(199705)13:6 · Cited by 20 · see citing works
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Mitoferrin is essential for erythroid iron assimilation
Shaw, G. C., Cope, J. J., Li, L., Corson, K., Hersey, C., Ackermann, G. E., Gwynn, B., Lambert, A. J., Wingert, R. A., Traver, D., et al. (2006) · Nature · doi:10.1038/nature04512 · Cited by 624 · see citing works
Forging a field: the golden age of iron biology.
Andrews, N. C. (2008) · Blood · doi:10.1182/blood-2007-12-077388 · Cited by 623 · see citing works
Maturation of Iron-Sulfur Proteins in Eukaryotes: Mechanisms, Connected Processes, and Diseases
Lill, R., & Mühlenhoff, U. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.052705.162653 · Cited by 595 · see citing works
Richardson, D. R., Lane, D. J. R., Becker, E. M., Huang, M. L.-H., Whitnall, M., Rahmanto, Y. S., Sheftel, A. D., & Ponka, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912925107 · Cited by 536 · see citing works
Intracellular iron transport and storage: from molecular mechanisms to health implications
Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526 · see citing works
The role of mitochondria in cellular iron–sulfur protein biogenesis and iron metabolism
Lill, R., Hoffmann, B., Molik, S., Pierik, A. J., Rietzschel, N., Stehling, O., Uzarska, M. A., Webert, H., Wilbrecht, C., & Mühlenhoff, U. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.009 · Cited by 501 · see citing works
Iron–sulphur cluster biogenesis and mitochondrial iron homeostasis
Rouault, T. A., & Tong, W.-H. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1620 · Cited by 432 · see citing works
Lane, D. J. R., Merlot, A. M., Huang, M. L.-H., Bae, D.-H., Jansson, P. J., Sahni, S., Kalinowski, D. S., & Richardson, D. R. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.01.021 · Cited by 399 · see citing works
Iron-Sulfur Protein Biogenesis in Eukaryotes: Components and Mechanisms
Lill, R., & Mühlenhoff, U. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104538 · Cited by 365 · see citing works
Paradkar, P. N., Zumbrennen, K. B., Paw, B. H., Ward, D. M., & Kaplan, J. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01685-08 · Cited by 362 · see citing works
Haas, H. (2003) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-003-1335-2 · Cited by 334 · see citing works
Rutherford, J. C., & Bird, A. J. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.1.1-13.2004 · Cited by 293 · see citing works
Frataxin-mediated Iron Delivery to Ferrochelatase in the Final Step of Heme Biosynthesis
Yoon, T., & Cowan, J. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400107200 · Cited by 281 · see citing works
Mitochondrial iron–sulfur protein biogenesis and human disease
Stehling, O., Wilbrecht, C., & Lill, R. (2014) · Biochimie · doi:10.1016/j.biochi.2014.01.010 · Cited by 272 · see citing works
Direct interorganellar transfer of iron from endosome to mitochondrion
Sheftel, A. D., Zhang, A., Brown, C. M., Shirihai, O. S., & Ponka, P. (2007) · Blood · doi:10.1182/blood-2007-01-068148 · Cited by 266 · see citing works
Regulation of Cation Balance inSaccharomyces cerevisiae
Cyert, M., & Philpott, C. C. (2013) · Genetics · doi:10.1534/genetics.112.147207 · Cited by 253 · see citing works
The long history of iron in the Universe and in health and disease
Sheftel, A. D., Mason, A. B., & Ponka, P. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.08.002 · Cited by 234 · see citing works
Iron use for haeme synthesis is under control of the yeast frataxin homologue (Yfh1)
Lesuisse, E. (2003) · Human Molecular Genetics · doi:10.1093/hmg/ddg096 · Cited by 226 · see citing works
Chen, W., Paradkar, P. N., Li, L., Pierce, E. L., Langer, N. B., Takahashi‐Makise, N., Hyde, B. B., Shirihai, O. S., Ward, D. M., Kaplan, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904519106 · Cited by 220 · see citing works
Maio, N., & Rouault, T. A. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.09.009 · Cited by 215 · see citing works
Singh, N., Haldar, S., Tripathi, A. K., Horback, K., Wong, J., Sharma, D., Beserra, A., Suda, S., Anbalagan, C., Dev, S., et al. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4931 · Cited by 205 · see citing works
Mitochondrial Iron in Human Health and Disease
Ward, D. M., & Cloonan, S. M. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020518-114742 · Cited by 200 · see citing works
The role of iron in mitochondrial function
Levi, S., & Rovida, E. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.008 · Cited by 195 · see citing works
Mühlenhoff, U., Stadler, J. A., Richhardt, N., Seubert, A., Eickhorst, T., Schweyen, R. J., Lill, R., & Wiesenberger, G. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307847200 · Cited by 193 · see citing works
Aft1p and Aft2p Mediate Iron-responsive Gene Expression in Yeast through Related Promoter Elements
Rutherford, J. C., Jaron, S., & Winge, D. R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300076200 · Cited by 192 · see citing works
Iron and Copper in Mitochondrial Diseases
Xu, W., Barrientos, T., & Andrews, N. C. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.004 · Cited by 182 · see citing works
The rice mitochondrial iron transporter is essential for plant growth
Bashir, K., Ishimaru, Y., Shimo, H., Nagasaka, S., Fujimoto, M., Takanashi, H., Tsutsumi, N., An, G., Nakanishi, H., & Nishizawa, N. K. (2011) · Nature Communications · doi:10.1038/ncomms1326 · Cited by 172 · see citing works
Mechanisms of iron–sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes
Lill, R., Dutkiewicz, R., Elsässer, H., Hausmann, A., Netz, D. J. A., Pierik, A. J., Stehling, O., Urzica, E. I., & Mühlenhoff, U. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.011 · Cited by 170 · see citing works
Palmieri, F., Agrimi, G., Blanco, E., Castegna, A., Noia, M. A. D., Iacobazzi, V., Lasorsa, F. M., Marobbio, C. M. T., Palmieri, L., Scarcia, P., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.05.023 · Cited by 169 · see citing works
The mitochondrion: a central architect of copper homeostasis
Baker, Z. N., Cobine, P. A., & Leary, S. C. (2017) · Metallomics · doi:10.1039/c7mt00221a · Cited by 167 · see citing works
Iron transport in plants: better be safe than sorry
Thomine, S., & Vert, G. (2013) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2013.01.003 · Cited by 162 · see citing works
Huang, M., Chiang, S., Kalinowski, D. S., Bae, D.-H., Sahni, S., & Richardson, D. R. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/6392763 · Cited by 154 · see citing works
Metal Acquisition and Availability in the Mitochondria
Atkinson, A., & Winge, D. R. (2009) · Chemical Reviews · doi:10.1021/cr900006y · Cited by 146 · see citing works
The Effects of Mitochondrial Iron Homeostasis on Cofactor Specificity of Superoxide Dismutase 2
Yang, M., Cobine, P. A., Molik, S., Naranuntarat, A., Lill, R., Winge, D. R., & Culotta, V. C. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601064 · Cited by 143 · see citing works
Characterization of Iron-Sulfur Protein Assembly in Isolated Mitochondria
Mühlenhoff, U., Richhardt, N., Gerber, J., & Lill, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204675200 · Cited by 122 · see citing works
A non-essential function for yeast frataxin in iron-sulfur cluster assembly
Duby, G. (2002) · Human Molecular Genetics · doi:10.1093/hmg/11.21.2635 · Cited by 117 · see citing works
Ramazzotti, A., Vanmansart, V., & Foury, F. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01498-4 · Cited by 116 · see citing works
Self-citationZebrafish in the sea of mineral (iron, zinc, and copper) metabolism
Zhao, L., Xia, Z., & Wang, F. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00033 · Cited by 114 · see citing works
Zhang, Y., Lyver, E. R., Knight, S. A. B., Lesuisse, E., & Dancis, A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500397200 · Cited by 111 · see citing works
Froschauer, E. M., Schweyen, R. J., & Wiesenberger, G. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.03.004 · Cited by 110 · see citing works
A Mitochondrial-Vacuolar Signaling Pathway in Yeast That Affects Iron and Copper Metabolism
Li, L., & Kaplan, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403146200 · Cited by 109 · see citing works
Courel, M., Lallet, S., Camadro, J., & Blaiseau, P.-L. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.15.6760-6771.2005 · Cited by 108 · see citing works
Cellular and mitochondrial iron homeostasis in vertebrates
Chen, C., & Paw, B. H. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.01.003 · Cited by 106 · see citing works
Mitochondrial Mayhem: The Mitochondrion as a Modulator of Iron Metabolism and Its Role in Disease
Huang, M. L.-H., Lane, D. J. R., & Richardson, D. R. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3921 · Cited by 103 · see citing works
Metal Ion availability in mitochondria
Pierrel, F., Cobine, P. A., & Winge, D. R. (2007) · BioMetals · doi:10.1007/s10534-006-9052-9 · Cited by 105 · see citing works
Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria
Troadec, M.-B., Warner, D., Wallace, J., Thomas, K., Spangrude, G. J., Phillips, J., Khalimonchuk, O., Paw, B. H., Ward, D. M., & Kaplan, J. (2011) · Blood · doi:10.1182/blood-2010-11-319483 · Cited by 97 · see citing works
Mrs3p, Mrs4p, and Frataxin Provide Iron for Fe-S Cluster Synthesis in Mitochondria
Zhang, Y., Lyver, E. R., Knight, S. A. B., Pain, D., Lesuisse, E., & Dancis, A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604246200 · Cited by 98 · see citing works
Mitochondrial ferritin in the regulation of brain iron homeostasis and neurodegenerative diseases
Gao, G., & Chang, Y. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00019 · Cited by 97 · see citing works
Compartmentalization of iron between mitochondria and the cytosol and its regulation
Mühlenhoff, U., Hoffmann, B., Richter, N., Rietzschel, N., Spantgar, F., Stehling, O., Uzarska, M. A., & Lill, R. (2015) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2015.05.003 · Cited by 95 · see citing works
New mitochondrial carriers: an overview
del Arco, A., & Satrústegui, J. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5197-x · Cited by 93 · see citing works
MDL1 is a High Copy Suppressor of ATM1: Evidence for a Role in Resistance to Oxidative Stress
Chloupková, M., LeBard, L. S., & Koeller, D. M. (2003) · Journal of Molecular Biology · doi:10.1016/s0022-2836(03)00666-1 · Cited by 92 · see citing works
The Ferroxidase Activity of Yeast Frataxin
Park, S., Gakh, O., Mooney, S. M., & Isaya, G. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206711200 · Cited by 88 · see citing works
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Dietz, J. V., Fox, J. L., & Khalimonchuk, O. (2021) · Cells · doi:10.3390/cells10092198 · Cited by 89 · see citing works
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Kozlov, S. O., Afonin, A. М., Evsyukov, I., & Бондаренко, А. Б. (2017) · Reviews in the Neurosciences · doi:10.1515/revneuro-2017-0006 · Cited by 84 · see citing works
Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae
Hildyard, J. C. W., & Halestrap, A. P. (2003) · Biochemical Journal · doi:10.1042/bj20030995 · Cited by 82 · see citing works
Metzendorf, C., & Lind, M. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-68 · Cited by 79 · see citing works
From the discovery to molecular understanding of cellular iron-sulfur protein biogenesis
Lill, R. (2020) · Biological Chemistry · doi:10.1515/hsz-2020-0117 · Cited by 75 · see citing works
Mitochondrial iron transport and homeostasis in plants
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Mitoferrin, Cellular and Mitochondrial Iron Homeostasis
Ali, M. Y., Oliva, C. R., Flor, S., & Griguer, C. E. (2022) · Cells · doi:10.3390/cells11213464 · Cited by 66 · see citing works
Iron Metabolism and Mitochondrial Abnormalities in Friedreich Ataxia
Pandolfo, M. (2002) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2002.0591 · Cited by 65 · see citing works
Irazusta, V. P., Cabiscol, E., Reverter‐Branchat, G., Ros, J., & Tamarit, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511649200 · Cited by 63 · see citing works
Loguinov, A. V., Mian, S. I., & Vulpe, C. D. (2004) · Genome biology · doi:10.1186/gb-2004-5-3-r18 · Cited by 65 · see citing works
Seguin, A., Jia, X., Earl, A. M., Li, L., Wallace, J. A., Qiu, A., Bradley, T., Shrestha, R., Troadec, M., Hockin, M., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013229 · Cited by 60 · see citing works
Mitoferrin modulates iron toxicity in a Drosophila model of Friedreich׳s ataxia
Navarro, J. A., Botella, J., Metzendorf, C., Lind, M., & Schneuwly, S. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.014 · Cited by 60 · see citing works
Essential and Detrimental — an Update on Intracellular Iron Trafficking and Homeostasis
Vigani, G., Solti, Ï., Thomine, S. ⁄. B., & Philippar, K. (2019) · Plant and Cell Physiology · doi:10.1093/pcp/pcz091 · Cited by 60 · see citing works
Iron Dysregulation in Friedreich Ataxia
Wilson, R. B. (2006) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2006.08.005 · Cited by 59 · see citing works
Holmes‐Hampton, G. P., Jhurry, N. D., McCormick, S. P., & Lindahl, P. A. (2012) · Biochemistry · doi:10.1021/bi3015339 · Cited by 56 · see citing works
Fixing frataxin: ‘ironing out’ the metabolic defect in F riedreich's ataxia
Anzovino, A., Lane, D. J. R., Huang, M. L. H., & Richardson, D. R. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12470 · Cited by 55 · see citing works
Gómez-Gallardo, M., Pérez‐Gallardo, R. V., Sánchez, L. A., Díaz-Pérez, A. L., Cortés‐Rojo, C., Meza‐Carmen, V., Saavedra‐Molina, A., Lara‐Romero, J., Jiménez‐Sandoval, S., Rodríguez, F., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111585 · Cited by 54 · see citing works
Mittra, B., Laranjeira‐Silva, M. F., de Menezes, J. P. B., Jensen, J., Michailowsky, V., & Andrews, N. W. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005340 · Cited by 54 · see citing works
Bailão, M. G. S., Schrank, A., Bailão, E. F. L. C., Bailão, A. M., Borges, C. L., Staats, C. C., Parente, J. A., Pereira, M., Salem‐Izacc, S. M., Mendes‐Giannini, M. J. S., et al. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00049 · Cited by 53 · see citing works
Christenson, E. T., Gallegos, A. S., & Banerjee, A. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.817478 · Cited by 50 · see citing works
Misslinger, M., Lechner, B. E., Bacher, K., & Haas, H. (2018) · Metallomics · doi:10.1039/c8mt00263k · Cited by 49 · see citing works
Mechanisms of cellular iron sensing, regulation of erythropoiesis and mitochondrial iron utilization
Maio, N., Zhang, D., Ghosh, M. C., Jain, A., SantaMaria, A. M., & Rouault, T. A. (2021) · Seminars in Hematology · doi:10.1053/j.seminhematol.2021.06.001 · Cited by 49 · see citing works
Sheftel, A. D., & Lill, R. (2008) · Annals of Medicine · doi:10.1080/07853890802322229 · Cited by 48 · see citing works
Exploratory and Confirmatory Gene Expression Profiling of mac1Δ
Freitas, J. M. D., Kim, J. H., Poynton, H. C., Su, T., Henri Wintz, A., Fox, T. C., Holman, P., Loguinov, A. V., Keleş, S., van der Laan, M. J., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m212308200 · Cited by 48 · see citing works
Metzendorf, C., Wu, W., & Lind, M. (2009) · Biochemical Journal · doi:10.1042/bj20082231 · Cited by 47 · see citing works
Busi, M. V., & Gomez‐Casati, D. F. (2011) · IUBMB Life · doi:10.1002/iub.577 · Cited by 46 · see citing works
Moreno-Cermeño, A., Òbis, È., Bellı́, G., Cabiscol, E., Ros, J., & Tamarit, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.149443 · Cited by 43 · see citing works
Jain, A., Dashner, Z. S., & Connolly, E. L. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01449 · Cited by 42 · see citing works
Kim, L. J., Tsuyuki, K. M., Hu, F., Park, E. Y., Zhang, J., Iraheta, J. G., Chia, J., Huang, R., Tucker, A. E., Clyne, M., et al. (2021) · The Plant Journal · doi:10.1111/tpj.15286 · Cited by 44 · see citing works
Ren, Y., Yang, S., Tan, G., Ye, W., Liu, D., Xu, Q., Ding, Z., Zhong, Y., Zhang, J., Jiang, D., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029666 · Cited by 41 · see citing works
Hudder, B. N., Morales, J. G., Stubna, A., Münck, E., Hendrich, M. P., & Lindahl, P. A. (2007) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-007-0275-1 · Cited by 40 · see citing works
Li, L., Murdock, G., Bagley, D., Jia, X., Ward, D. M., & Kaplan, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.096859 · Cited by 38 · see citing works
Long, N., Xu, X., Qian, H., Zhang, S., & Lü, L. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00716 · Cited by 36 · see citing works
The mitochondrial carrier Rim2 co-imports pyrimidine nucleotides and iron
Froschauer, E. M., Rietzschel, N., Hassler, M. R., Binder, M., Schweyen, R. J., Lill, R., Mühlenhoff, U., & Wiesenberger, G. (2013) · Biochemical Journal · doi:10.1042/bj20130144 · Cited by 35 · see citing works
Vallières, C., Trouillard, M., Dujardin, G., & Meunier, B. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.02548-10 · Cited by 35 · see citing works
Jensen, L. T., Sanchez, R. J., Srinivasan, C., Valentine, J., & Culotta, V. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402795200 · Cited by 35 · see citing works
pÃrek, M. Å., Poláková, S., Jatzová, K., & Sulo, P. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2014.00454 · Cited by 34 · see citing works
Ward, D. M., Chen, O. S., Li, L., Kaplan, J., Bhuiyan, S. A., Natarajan, S. K., Bard, M., & Cox, J. E. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.001781 · Cited by 32 · see citing works
Li, L., Miao, R., Jia, X., Ward, D. M., & Kaplan, J. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.574723 · Cited by 30 · see citing works
Biophysical Investigation of the Iron in Aft1-1up and Gal-YAH1 Saccharomyces cerevisiae
Miao, R., Holmes‐Hampton, G. P., & Lindahl, P. A. (2011) · Biochemistry · doi:10.1021/bi102015s · Cited by 30 · see citing works
Power2: The power of yeast genetics applied to the powerhouse of the cell
Rutter, J. P., & Hughes, A. L. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.12.002 · Cited by 29 · see citing works
The regulation of iron homeostasis in the fungal human pathogen Candida glabrata
Devaux, F., & Thiébaut, A. (2019) · Microbiology · doi:10.1099/mic.0.000807 · Cited by 29 · see citing works
Drosophila melanogaster Mitochondrial Carriers: Similarities and Differences with the Human Carriers
Curcio, R., Lunetti, P., Zara, V., Ferramosca, A., Marra, F., Fiermonte, G., Cappello, A. R., Leonardis, F. D., Capobianco, L., & Dolce, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176052 · Cited by 28 · see citing works
Mammalian iron sulfur cluster biogenesis and human diseases
Maio, N., & Rouault, T. A. (2022) · IUBMB Life · doi:10.1002/iub.2597 · Cited by 28 · see citing works
Llorens, J. V., Metzendorf, C., Missirlis, F., & Lind, M. (2015) · JBIC Journal of Biological Inorganic Chemistry · doi:10.1007/s00775-015-1302-2 · Cited by 28 · see citing works
Identification and functional characterization of mitochondrial carrier Mrs4 inCandida albicans
Xu, N., Cheng, X., Yu, Q., Zhang, B., Ding, X., Xing, L., & Li, M. (2012) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2012.00835.x · Cited by 27 · see citing works
Wofford, J. D., & Lindahl, P. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.676668 · Cited by 27 · see citing works
Mitochatting – If only we could be a fly on the cell wall
Eisenberg‐Bord, M., & Schuldiner, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2017.04.012 · Cited by 26 · see citing works
- Authors
- Foury, F., & Roganti, T.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Foury, Françoise
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2002-07
- Volume
- 277
- Issue
- 27
- Pages
- 24475-24483
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2035410822
- Cited by
- 171
- References
- 34
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 4 · 2015: 8 · 2014: 12 · 2013: 10 · 2012: 5
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- mitochondrial carrier protein, mitochondrial iron accumulation, frataxin, iron regulon, mitochondrial genome stability, heme biosynthesis, ferrochelatase, Saccharomyces cerevisiae
- MeSH terms
- Frataxin, Base Sequence, Carrier Proteins, Cell Division, DNA, Mitochondrial, Fungal Proteins, Kinetics, Mitochondria, Repressor Proteins, Saccharomyces cerevisiae, Suppression, Genetic, Genome, Fungal, Gene Deletion, Phosphotransferases (Alcohol Group Acceptor), DNA Primers, Mitochondrial Proteins, Cation Transport Proteins, Saccharomyces cerevisiae Proteins, Iron-Binding Proteins
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