Cited by 532Neurobiology and Insect Physiology ResearchSteroid Chemistry and BiochemistryLipid metabolism and biosynthesis

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Control and Biochemical Nature of the Ecdysteroidogenic Pathway

Gilbert, Lawrence I., Rybczynski, Robert, Warren, James T.·2002·Annual Review of Entomology

DOI 10.1146/annurev.ento.47.091201.145302

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Abstract

Molting is elicited by a critical titer of ecdysteroids that includes the principal molting hormone, 20-hydroxyecdysone (20E), and ecdysone (E), which is the precursor of 20E but also has morphogenetic roles of its own. The prothoracic glands are the predominate source of ecdysteroids, and the rate of synthesis of these polyhydroxylated sterols is critical for molting and metamorphosis. This review concerns three aspects of ecdysteroidogenesis: (a) how the brain neuropeptide prothoracicotropic hormone (PTTH) initiates a transductory cascade in cells of the prothoracic gland, which results in an increased rate of ecdysteroid biosynthesis (upregulation); (b) how the concentrations of 20E in the hemolymph feed back on the prothoracic gland to decrease rates of ecdysteroidogenesis (downregulation); and (c) how the prothoracic gland cells convert cholesterol to the precursor of E and then 20E, a series of reactions only now being understood because of the use of a combination of classical biochemistry and molecular genetics.

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The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,394
Comprehensive insect physiology, biochemistry and pharmacology
(1985) · Journal of Insect Physiology · doi:10.1016/0022-1910(85)90117-9 · Cited by 4,819
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
Pratt, W. B., & Toft, D. O. (1997) · Endocrine Reviews · doi:10.1210/edrv.18.3.0303 · Cited by 1,791
Signal Transduction through MAP Kinase Cascades
Lewis, T. S., Shapiro, P. S., & Ahn, N. G. (1998) · Advances in cancer research · doi:10.1016/s0065-230x(08)60765-4 · Cited by 1,759
Evidence for a clade of nematodes, arthropods and other moulting animals
Aguinaldo, A. M. A., Turbeville, J. M., Linford, L. S., Rivera, M. C., Garey, J. R., Raff, R. A., & Lake, J. A. (1997) · Nature · doi:10.1038/387489a0 · Cited by 1,609
Comprehensive insect physiology, biochemistry and pharmacology
Brooks, G. T. (1985) · Insect Biochemistry · doi:10.1016/0020-1790(85)90131-3 · Cited by 1,595
Mutations affecting the pattern of the larval cuticle inDrosophila melanogaster
N�sslein-Volhard, C., Wieschaus, E. F., & Kluding, H. (1984) · Development Genes and Evolution · doi:10.1007/bf00848156 · Cited by 1,552
A Family of cAMP-Binding Proteins That Directly Activate Rap1
Kawasaki, H., Springett, G. M., Mochizuki, N., Toki, S., Nakaya, M., Matsuda, M., Housman, D. E., & Graybiel, A. M. (1998) · Science · doi:10.1126/science.282.5397.2275 · Cited by 1,386
Regulation of the acute production of steroids in steroidogenic cells
STOCCO, D. M., & CLARK, B. J. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-3-221 · Cited by 1,057
The drosophila EcR gene encodes an ecdysone receptor, a new member of the steroid receptor superfamily
Koelle, M. R., Talbot, W. S., Segraves, W. A., Bender, M. T., Cherbas, P. T., & Hogness, D. S. (1991) · Cell · doi:10.1016/0092-8674(91)90572-g · Cited by 966

Show all 185 references

Research works printed but not linked: 14

Bergamasco R, Horn DHS. 1980. The biological activities of ecdysteroids and ecdysteroid analogues. In Progress in Ecdysone Research , ed. JA Hoffmann, 7:299–324. Amsterdam/New York/Oxford: Elsevier/North Holland Biomed.
Böcking D, 1994, C. R. Acad. Sci. Paris, 317, 891
10.1210/me.9.11.1549 · DOI
10.1210/me.8.12.1731 · DOI
Fujimoto Y, 2000, AOCS Press, 35, 279
Gelman DB, 1995, Eur. J. Entomol., 92, 123
Gilbert LI, 1967, Adv. Insect Physiol., 4, 169
Ishizaki H, 1994, Int. J. Dev., 38, 301
Kappler C, Hetru C, Durst F, Hoffmann JA. 1989. Enzymes involved in ecdysone biosynthesis. In Ecdysone: From Chemistry to Mode of Action , ed. J Koolman, pp. 161–66. Stuttgart: Georg Thieme-Verlag
10.1210/me.9.7.838 · DOI
Nakanishi K, 1966, J. Chem. Soc. Chem. Commun., 915
Rees HH, 1995, Eur. J. Entomol., 92, 9
Rybczynski R, 2001, Mol. Cell. Endocrinol.
Smith WA, 1997, Arch. Insect Biochem. Physiol., 30, 579

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Authors: Gilbert, L. I., Rybczynski, R., & Warren, J. T.
Affiliations: University of North Carolina at Chapel Hill (US)
Venue: Annual Review of Entomology
Publisher: Annual Reviews
Published: 2002-01
Volume: 47
Issue: 1
Pages: 883-916
ISSN: 0066-4170 (ISSN-L)
1545-4487
DOI: 10.1146/annurev.ento.47.091201.145302
OpenAlex: W2157228103
Cited by: 532
References: 185
Citations by year: 2026: 15 · 2025: 20 · 2024: 16 · 2023: 14 · 2022: 14 · 2021: 21 · 2020: 32 · 2019: 20 · 2018: 11 · 2017: 13 · 2016: 20 · 2015: 21 · 2014: 31 · 2013: 28 · 2012: 26
FWCI: 2.40
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Entomology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: ecdysteroid biosynthesis, 20-hydroxyecdysone, ecdysone, prothoracic gland, prothoracicotropic hormone, molting, metamorphosis, cholesterol conversion, steroidogenesis, insect endocrinology
MeSH terms: Animals, Insecta, Down-Regulation, Ecdysteroids

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Control and Biochemical Nature of the Ecdysteroidogenic Pathway

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