Three-Dimensional Reconstruction of Brain-wide Wiring Networks in Drosophila at Single-Cell Resolution
Open accessAbstract
Background Animal behavior is governed by the activity of interconnected brain circuits. Comprehensive brain wiring maps are thus needed in order to formulate hypotheses about information flow and also to guide genetic manipulations aimed at understanding how genes and circuits orchestrate complex behaviors.Results To assemble this map, we deconstructed the adult Drosophila brain into approximately 16,000 single neurons and reconstructed them into a common standardized framework to produce a virtual fly brain. We have constructed a mesoscopic map and found that it consists of 41 local processing units (LPUs), six hubs, and 58 tracts covering the whole Drosophila brain. Despite individual local variation, the architecture of the Drosophila brain shows invariance for both the aggregation of local neurons (LNs) within specific LPUs and for the connectivity of projection neurons (PNs) between the same set of LPUs. An open-access image database, named FlyCircuit, has been constructed for online data archiving, mining, analysis, and three-dimensional visualization of all single neurons, brain-wide LPUs, their wiring diagrams, and neural tracts.Conclusion We found that the Drosophila brain is assembled from families of multiple LPUs and their interconnections. This provides an essential first step in the analysis of information processing within and between neurons in a complete brain.
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In the fly, large numbers of light microscopy reconstructions of single neurons have been aggregated to map projections between brain regions.
“In the fly, large numbers of light microscopy reconstructions of single neurons have been aggregated to map projections between brain regions77,78.”
From Neuronal wiring diagram of an adult brain (2024) · cites this paper as [78]
The FB2B neurons share the same cell body location and appear to match another type of tdc2-Gal4 expressing neurons in the FlyCircuit database.
“We also found that the FB2B neurons share the same cell body location and appear to match another type of tdc2-Gal4 expressing neurons in the FlyCircuit database.”
From A connectome and analysis of the adult Drosophila central brain (2020) · cites this paper as Chiang et al., 2011
In addition to the three cell types that match the octopaminergic neurons OA-ASM1, 2 and 3, the authors found two neuron types in the same location that appear to match some of the tdc2-Gal4 expressing neurons in the FlyCircuit database.
“in addition to the three cell types that match the octopaminergic (OA) neurons OA-ASM1, 2 and 3 (Busch et al., 2009), we found two neuron types in the same location that appear to match some of the tdc2-Gal4 expressing neurons in the FlyCircuit database of single-cell labeling images (Chiang et al., 2011).”
From A connectome and analysis of the adult Drosophila central brain (2020) · cites this paper as Chiang et al., 2011
With recent advances in computing power and optical imaging techniques, it is now feasible to systematically map connectivity throughout the entire brain.
“With recent advances in both computing power and optical imaging techniques, it is now feasible to systematically map connectivity throughout the entire brain.”
From A mesoscale connectome of the mouse brain (2014) · cites this paper as [7]
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- Authors
- Chiang, A.-S., Lin, C.-Y., Chuang, C.-C., Chang, H.-M., Hsieh, C.-H., Yeh, C.-W., Shih, C.-T., Wu, J.-J., Wang, G.-T., Chen, Y.-C., Wu, C.-C., Chen, G.-Y., Ching, Y.-T., Lee, P.-C., Lin, C.-Y., Lin, H.-H., Wu, C.-C., Hsu, H.-W., Huang, Y.-A., Chen, J.-Y., Chiang, H.-J., Lu, C.-F., Ni, R.-F., Yeh, C.-Y., & Hwang, J.-K.
- Affiliations
- National Tsing Hua University (TW)
- National Yang Ming Chiao Tung University (TW)
- National Center for High-Performance Computing (TW)
- Tunghai University (TW)
- Corresponding author
- Chiang, Ann-Shyn
- ORCID
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 21
- Issue
- 1
- Pages
- 1-11
- ISSN
- 0960-9822 (ISSN-L)
- OpenAlex
- W2169331639
- Cited by
- 767
- References
- 53
- Citations by year
- 2026: 12 · 2025: 21 · 2024: 27 · 2023: 32 · 2022: 28 · 2021: 38 · 2020: 52 · 2019: 47 · 2018: 64 · 2017: 58 · 2016: 60 · 2015: 64 · 2014: 74 · 2013: 80 · 2012: 68
- FWCI
- 24.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Earth Sciences
- National Science Council
- Ministry of Education, India
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- Drosophila brain, neuronal connectivity, projection neurons, local neurons, Virtual Fly Brain, 3D reconstruction, neural circuits
- MeSH terms
- Animals, Brain, Computer Simulation, Drosophila, Female, Male, Models, Biological, Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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