Cited by 145Evolution and Paleontology StudiesGenomics and Phylogenetic StudiesEvolution and Genetic Dynamics

Time scale of eutherian evolution estimated without assuming a constant rate of molecular evolution.

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Hasegawa, Masami, Thorne, Jeffrey L., Kishino, Hirohisa·2003·Genes & Genetic Systems

Abstract

Controversies over the molecular clock hypothesis were reviewed. Since it is evident that the molecular clock does not hold in an exact sense, accounting for evolution of the rate of molecular evolution is a prerequisite when estimating divergence times with molecular sequences. Recently proposed statistical methods that account for this rate variation are overviewed and one of these procedures is applied to the mitochondrial protein sequences and to the nuclear gene sequences from many mammalian species in order to estimate the time scale of eutherian evolution. This Bayesian method not only takes account of the variation of molecular evolutionary rate among lineages and among genes, but it also incorporates fossil evidence via constraints on node times. With denser taxonomic sampling and a more realistic model of molecular evolution, this Bayesian approach is expected to increase the accuracy of divergence time estimates.

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Research works printed but not linked: 3

  1. Graur, D., and Li, W.-H. (2000) Fundamentals of Molecular Evo- lution (2nd ed.). Sinauer Associates, Sunderland, MA.
  2. McKenna, M. C., and Bell, S. K. (1997) Classification of Mam- mals: Above the Species Level, Columbia Univ. Press, New York.
  3. Zuckerkandl, E., and Pauling, L. (1962) Molecular disease, evo- lution, and genic heterogeneity. In: Horizons in Biochemis- try (eds. M. Kasha and B. Pullman), pp. 189-225. Academic Press, New York.

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Authors
Hasegawa, M., Thorne, J. L., & Kishino, H.
Affiliations
  • The Graduate University for Advanced Studies, SOKENDAI (JP)
  • North Carolina State University (US)
  • The University of Tokyo (JP)
Venue
Genes & Genetic Systems
Published
2003
Volume
78
Issue
4
Pages
267-283
ISSN
  • 1341-7568 (ISSN-L)
  • 1880-5779
OpenAlex
W2001967468
Cited by
145
References
98
Citations by year
2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 21 · 2013: 3 · 2012: 7
FWCI
2.28
Type
journal article
Language
en
Open access
Locations
  • Genes & Genetic Systems (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Science Foundation
  • Mitsubishi Foundation
  • Japan Society for the Promotion of Science
Topics
  • Physical Sciences › Earth and Planetary Sciences › Paleontology › Evolution and Paleontology Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
Keywords
divergence time estimation, molecular clock, rate variation, Bayesian phylogenetics, fossil calibration, molecular evolution rate
MeSH terms
Animals, Bayes Theorem, Fossils, Humans, Mathematics, Models, Biological, Models, Genetic, Phylogeny, Probability, Time Factors, Genetic Variation, Evolution, Molecular

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