The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Allosteric Cascade of Spliceosome Activation
Abstract
▪ Abstract Introns are removed from precursor messenger RNAs in the cell nucleus by a large ribonucleoprotein complex called the spliceosome. The spliceosome contains five subcomplexes called snRNPs, each with one RNA and several protein components. Interactions of the snRNPs with each other and the intron are highly dynamic, changing in an ordered progression throughout the splicing process. This allosteric cascade of interactions is programmed into the RNA and protein components of the spliceosome, and is driven by a family of DExD/H-box RNA-dependent ATPases. The dependence of cascade progression on multiple intron-recognition events likely serves to enforce the accuracy of splicing. Here, the progression of the allosteric cascade from the first recognition event to the first catalytic step of splicing is reviewed.
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Citations
Cites
Genome-wide bioinformatic and molecular analysis of introns in Saccharomyces cerevisiae
SPINGOLA, M., GRATE, L., HAUSSLER, D., & ARES, M. (1999) · RNA · doi:10.1017/s1355838299981682 · Cited by 316
A stem/loop in U6 RNA defines a conformational switch required for pre-mRNA splicing.
Fortner, D. M., Troy, R. G., & Brow, D. A. (1994) · Genes & Development · doi:10.1101/gad.8.2.221 · Cited by 110
Self-citation
Cited by
Mechanisms of Alternative Pre-Messenger RNA Splicing
Black, D. L. (2003) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.72.121801.161720 · Cited by 2,704
The Spliceosome: Design Principles of a Dynamic RNP Machine
Wahl, M. C., Will, C. L., & Lührmann, R. (2009) · Cell · doi:10.1016/j.cell.2009.02.009 · Cited by 2,665
Spliceosome Structure and Function
Will, C. L., & Luhrmann, R. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003707 · Cited by 1,829
How did alternative splicing evolve?
Ast, G. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1451 · Cited by 555
Prp8 protein: At the heart of the spliceosome
GRAINGER, R. J., & BEGGS, J. D. (2005) · RNA · doi:10.1261/rna.2220705 · Cited by 372
Metadata
- Authors
- Brow, D. A.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2002-12
- Volume
- 36
- Issue
- 1
- Pages
- 333-360
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2166437079
- Cited by
- 372
- References
- 2
- FWCI
- 1.23
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
