The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
The Organization of the Bacterial Genome
Abstract
Many bacterial cellular processes interact intimately with the chromosome. Such interplay is the major driving force of genome structure or organization. Interactions take place at different scales—local for gene expression, global for replication—and lead to the differentiation of the chromosome into organizational units such as operons, replichores, or macrodomains. These processes are intermingled in the cell and create complex higher-level organizational features that are adaptive because they favor the interplay between the processes. The surprising result of selection for genome organization is that gene repertoires change much more quickly than chromosomal structure. Comparative genomics and experimental genomic manipulations are untangling the different cellular and evolutionary mechanisms causing such resilience to change. Since organization results from cellular processes, a better understanding of chromosome organization will help unravel the underlying cellular processes and their diversity.
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Cites
Single-cell proteomic analysis of S. cerevisiae reveals the architecture of biological noise
Newman, J. R. S., Ghaemmaghami, S., Ihmels, J., Breslow, D. K., Noble, M., DeRisi, J. L., & Weissman, J. S. (2006) · Nature · doi:10.1038/nature04785 · Cited by 1,483
Parkhill, J., Sebaihia, M., Preston, A., Murphy, L. D., Thomson, N., Harris, D. E., Holden, M. T. G., Churcher, C. M., Bentley, S. D., Mungall, K. L., et al. (2003) · Nature Genetics · doi:10.1038/ng1227 · Cited by 1,037
Kobayashi, I. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.18.3742 · Cited by 513
Evolution of gene order conservation in prokaryotes
Tamames, J. (2001) · Genome Biology · doi:10.1186/gb-2001-2-6-research0020 · Cited by 213 · cited 1×
“The frequency with which pairs of colocalized genes in a genome have orthologues that are also colocalized in the other genome is a measure of the disruption of gene order at a local scale since the last common ancestor of the two genomes (45, 106) (Figure 3a).”
BackgroundGene essentiality determines chromosome organisation in bacteria
Rocha, E. P. C. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg859 · Cited by 166
Self-citationPersistence drives gene clustering in bacterial genomes
Fang, G., Rocha, E. P., & Danchin, A. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-4 · Cited by 112 · cited 1×
“Essential genes stay for such long periods in the chromosome that they are bound to cluster at a given moment (30).”
BackgroundSelf-citationHighly variable rates of genome rearrangements between hemiascomycetous yeast lineages
Fischer, G., Rocha, E. P. C., Brunet, F., Vergassola, M., & Dujon, B. (2006) · PLoS Genetics · doi:10.1371/journal.pgen.0020032 · Cited by 101
Self-citationDetection and possible role of two large nondivisible zones on the Escherichia coli chromosome.
Rebollo, J. E., François, V, & Louarn, J. M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.24.9391 · Cited by 90
Chromosomal constraints in Gram‐positive bacteria revealed by artificial inversions
Campo, N., Dias, M. J., Daveran‐Mingot, M. ‐., Ritzenthaler, P., & Le Bourgeois, P. (2004) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03847.x · Cited by 68 · cited 2×
“Rearrangements changing the distance of a gene from the origin of replication will thus change its expression rate and affect optimal growth rates (11, 42).”
BackgroundDNA repeats lead to the accelerated loss of gene order in bacteria
Rocha, E. P. C. (2003) · Trends in Genetics · doi:10.1016/j.tig.2003.09.011 · Cited by 59 · cited 1×
“Therefore, there is a negative association between genome stability and repeat density (91), which is particularly striking if these repeats are transposable elements (103).”
BackgroundSelf-citation
Cited by
Applications of bioluminescence in biotechnology and beyond
Syed, A. J., & Anderson, J. C. (2021) · Chemical Society Reviews · doi:10.1039/d0cs01492c · Cited by 341
The GbsR family of transcriptional regulators: functional characterization of the OpuAR repressor.
Ronzheimer, S., Warmbold, B., Arnhold, C., & Bremer, E. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02536 · Cited by 9
Co-regulation of translation in protein complexes
Siwiak, M., & Zielenkiewicz, P. (2015) · Biology Direct · doi:10.1186/s13062-015-0048-7 · Cited by 8
Arnoux, J. (2026) · Thèse de doctorat, Université Paris-Saclay / PPanGGOLiN · doi:10.70675/eee354d9zf63dz48ebz9444zd1809f8fb74d
Metadata
- Authors
- Rocha, E. P. C.
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2008-12-01
- Volume
- 42
- Issue
- 1
- Pages
- 211-233
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2137119243
- Cited by
- 330
- References
- 11
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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