The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Transcriptional Control of Skeletogenesis
Open accessAbstract
The skeleton contains three specific cell types: chondrocytes in cartilage and osteoblasts and osteoclasts in bone. Our understanding of the transcriptional mechanisms that lead to cell differentiation along these three lineages has increased considerably in the past ten years. In the case of chondrocytes and osteoblasts advances have been made possible largely through the molecular elucidation of human skeletal dysplasias. This review discusses the key transcription factors that regulate skeletogenesis and highlights their function, mode of action, and regulation by other factors, with a special emphasis on how human genetics has contributed to this knowledge.
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Cites
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Cited by
Cellular and molecular mechanisms of bone remodeling
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The Role of Hypoxia in Development of the Mammalian Embryo
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Arterial calcification and bone physiology: role of the bone–vascular axis
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Metadata
- Authors
- Karsenty, G.
- Venue
- Annual Review of Genomics and Human Genetics
- Publisher
- Annual Reviews
- Published
- 2008-09-01
- Volume
- 9
- Issue
- 1
- Pages
- 183-196
- ISSN
- 1527-8204 (ISSN-L)
- 1545-293X
- OpenAlex
- W2151417014
- Cited by
- 391
- References
- 78
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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