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Cited by 1,655

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells

Auffray, Cedric, Sieweke, Michael H., Geissmann, Frederic·2009·Annual Review of Immunology

Abstract

Monocytes are circulating blood leukocytes that play important roles in the inflammatory response, which is essential for the innate response to pathogens. But inflammation and monocytes are also involved in the pathogenesis of inflammatory diseases, including atherosclerosis. In adult mice, monocytes originate in the bone marrow in a Csf-1R (MCSF-R, CD115)-dependent manner from a hematopoietic precursor common for monocytes and several subsets of macrophages and dendritic cells (DCs). Monocyte heterogeneity has long been recognized, but in recent years investigators have identified three functional subsets of human monocytes and two subsets of mouse monocytes that exert specific roles in homeostasis and inflammation in vivo, reminiscent of those of the previously described classically and alternatively activated macrophages. Functional characterization of monocytes is in progress in humans and rodents and will provide a better understanding of the pathophysiology of inflammation.

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Crossref · 10.1146/annurev.immunol.021908.132557

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Metadata

Authors
Auffray, C., Sieweke, M. H., & Geissmann, F.
Venue
Annual Review of Immunology
Published
2009-04-01
Volume
27
Issue
1
Pages
669-692
ISSN
  • 0732-0582 (ISSN-L)
  • 1545-3278
OpenAlex
W2156013098
Cited by
1,655
References
34
FWCI
6.92
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells. https://app.cochat.ai/papers/10.1146/annurev.immunol.021908.132557
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Auffray, C., Sieweke, M. H., & Geissmann, F. (2009). Blood Monocytes: Development, Heterogeneity, and Relationship with Dendritic Cells. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.021908.132557

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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