The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM
Abstract
▪ Abstract The immune system relies on cell death to maintain lymphoid homeostasis and avoid disease. Recent evidence has indicated that the caspase family of cysteine proteases is a central effector in apoptotic cell death and is absolutely responsible for many of the morphological features of apoptosis. Cell death, however, can occur through caspase-independent and caspase-dependent pathways. In the case of cells that are irreversibly neglected or damaged, death occurs even in the absence of caspase activity. In contrast, healthy cells require caspase activation to undergo cell death induced by surface receptors. This review summarizes the current understanding of these two pathways of cell death in the immune system.
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Cites
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CD95-Induced Apoptosis of Lymphocytes in an Immune Privileged Site Induces Immunological Tolerance
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Cited by
Delves, P. J., & Roitt, I. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007063430107 · Cited by 1,666
Lymphocyte-Mediated Cytotoxicity
Russell, J. H., & Ley, T. J. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100201.131730 · Cited by 1,122
Keel, M., & Trentz, O. (2005) · Injury · doi:10.1016/j.injury.2004.12.037 · Cited by 885
Hepatic T cells and liver tolerance
Crispe, I. N. (2003) · Nature Reviews Immunology · doi:10.1038/nri981 · Cited by 661
Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes
Pua, H. H., Guo, J., Komatsu, M., & He, Y.-W. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801143 · Cited by 423
Metadata
- Authors
- Rathmell, J. C., & Thompson, C. B.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1999-04
- Volume
- 17
- Issue
- 1
- Pages
- 781-828
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2157549025
- Cited by
- 379
- References
- 9
- FWCI
- 2.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rathmell, J. C., & Thompson, C. B. (1999). THE CENTRAL EFFECTORS OF CELL DEATH IN THE IMMUNE SYSTEM. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.17.1.781
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
