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Hematopoietic Stem Cell Heterogeneity

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Clinical benefit of immune checkpoint inhibitors in elderly cancer patients: Current evidence from immunosenescence pathophysiology to clinical trial results

Ziogas, D. C., Theocharopoulos, C., Aravantinou-Fatorou, K., Boukouris, A. E., Stefanou, D. T., Anastasopoulou, A. N., Lialios, P., Lyrarakis, G., & Gogas, H. J. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104635 · Cited by 19 · see citing works

DNA damage and aging on hematopoietic stem cells: Impact of oxidative stress in ApoE−/− mice

Aires, R., Porto, M. L., de Assis, L. M., Pereira, P. A. N., Carvalho, G. R., Côco, L. Z., Vasquez, E. C., Pereira, T. D. M. C., Campagnaro, B. P., & Meyrelles, S. S. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111607 · Cited by 17 · see citing works

A cellular identity crisis? Plasticity changes during aging and rejuvenationPreprint

Gorelov, R. A., & Hochedlinger, K. (2024) · Genes & Development · doi:10.1101/gad.351728.124 · Cited by 18 · see citing works

Selenomethionine protects hematopoietic stem/progenitor cells against cobalt nanoparticles by stimulating antioxidant actions and DNA repair functions

Zhu, W., Liu, Y., Zhang, W., Fan, W., Wang, S., Gu, J., Sun, H., & Liu, F. (2021) · Aging · doi:10.18632/aging.202865 · Cited by 15 · see citing works

The Roles of Myeloid Cells in Aging-related Liver Diseases

Yao, J., Li, Y., & Wang, H. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.82352 · Cited by 15 · see citing works

Stem cell decoupling underlies impaired lymphoid development during aging

Jang, G., Contreras, S., Esteva, E., Upadhaya, S., Feng, J., Adams, N. M., Richard, É., Awatramani, R. B., Sawai, C. M., & Reizis, B. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2302019120 · Cited by 17 · see citing works

Aging impairs the ability of vascular endothelial stem cells to generate endothelial cells in mice

Shimizu, S., Iba, T., Naito, H., Rahmawati, F. N., Konishi, H., Jia, W., Muramatsu, F., & Takakura, N. (2023) · Angiogenesis · doi:10.1007/s10456-023-09891-8 · Cited by 16 · see citing works

Age-associated changes in the gut microbiome impact efficacy of tumor immunomodulatory treatments

Singh, A., Ashar, H. K., Butcher, J. T., & Ranjan, A. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112268 · Cited by 14 · see citing works

Immune senescence: A key player in cancer biology

Yang, Y., Fan, L., Li, M., & Wang, Z. (2024) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2024.12.001 · Cited by 13 · see citing works

Restoration of aged hematopoietic cells by their young counterparts through instructive microvesicles release

Greco, S. J., Ayer, S., Guiro, K., Sinha, G., DONNELLY, R. J., El-Far, M. H., Pamarthi, S. H., Sandiford, O. A., Gergues, M., Sherman, L. S., et al. (2021) · Aging · doi:10.18632/aging.203689 · Cited by 12 · see citing works

CASIN exerts anti‐aging effects through RPL4 on the skin of naturally aging mice

Zhang, Y., Wang, X., Huang, J., Zhang, X., Bu, L., Zhang, Y., Liang, F., Wu, S., Zhang, M., Zhang, L., et al. (2024) · Aging Cell · doi:10.1111/acel.14333 · Cited by 11 · see citing works

Opportunities and Challenges in Stem Cell Aging

Larijani, B. A., Heravani, N. F., Alaei, S., Rezaei–Tavirani, M., Alavi-Moghadam, S., Payab, M., Goodarzi, P., Tayanloo-Beik, A., Aghayan, H. R., & Arjmand, B. (2021) · Advances in experimental medicine and biology · doi:10.1007/5584_2021_624 · Cited by 10 · see citing works

Purine metabolism in bone marrow microenvironment inhibits hematopoietic stem cell differentiation under microgravity

Liu, X., Zhang, H., Yan, J., Ye, P., Wang, Y., Zhang, N., Tian, Z., Liu, B., & Yang, H. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04213-9 · Cited by 8 · see citing works

Aging and immunity: the age-old tangoPreprint

Fernández-Maestre, I., Harris, A. S., & Amor, C. (2025) · Genes & Development · doi:10.1101/gad.352644.125 · Cited by 8 · see citing works

Epigenetic Mechanisms in Hematologic Aging and Premalignant Conditions

Yan, B., Yuan, Q., & Guryanova, O. A. (2023) · Epigenomes · doi:10.3390/epigenomes7040032 · Cited by 8 · see citing works

CASIN the joint: immune aging at the stem cell level

Pawelec, G. (2018) · Blood · doi:10.1182/blood-2018-06-858696 · Cited by 7 · see citing works

Age-related schwannomatosis with potential exosome-mediated contribution to prostate hyperplasia: a case report and mini-review

Chignon‐Sicard, B., Hofman, V., Chevallier, D., Cucchi, J. M., Ilié, M., Dadone‐Montaudié, B., Paul, F., Carpentier, X., Quintens, H., Bence-Gauchiez, C., et al. (2019) · Therapeutic Advances in Urology · doi:10.1177/1756287219875578 · Cited by 6 · see citing works

The p53 effector Perp mediates the persistence of CD4+ effector memory T-cell undergoing lymphopenia-induced proliferation

Zhou, Y. N., Leng, X., Mo, C., Zou, Q., Liu, Y., & Wang, Y. (2020) · Immunology Letters · doi:10.1016/j.imlet.2020.05.001 · Cited by 6 · see citing works

Research progress on blood therapy for anti-aging

Liu, S., Wang, S., Dong, Y., Yang, S., & Yao, C. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.039 · Cited by 5 · see citing works

Role of Rho Family Small GTPases in the Regulation of Normal and Pathological Processes

Bobkov, D. E., Lukacheva, A., Gorb, A. I., & Poljanskaya, G. G. (2024) · Cell and Tissue Biology · doi:10.1134/s1990519x24700159 · Cited by 5 · see citing works

A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice

Konturek-Cieśla, A., Zhang, Q., Kharazi, S., & Bryder, D. (2025) · Nature Communications · doi:10.1038/s41467-025-60464-3 · Cited by 5 · see citing works

The aging immune system: Dysregulation, compensatory mechanisms, and prospects for intervention

Müller, L., & Pawelec, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-815962-0.00016-0 · Cited by 5 · see citing works

FGD5 marks a subpopulation of hematopoietic stem and progenitor cells that resist interferon-γ-mediated differentiation

Morales-Mantilla, D. E., & King, K. Y. (2022) · Experimental Hematology · doi:10.1016/j.exphem.2022.06.001 · Cited by 5 · see citing works

Hautalterung – zelluläre Seneszenz

Scharffetter‐­Kochanek, K., Wang, Y., Makrantonaki, E., Crișan, D., Wlaschek, M., Geiger, H., & Maity, P. (2023) · Die Dermatologie · doi:10.1007/s00105-023-05201-x · Cited by 5 · see citing works

Long‐term tracking of haematopoietic clonal dynamics and mutations in non‐human primate undergoing transplantation of lentivirally barcoded haematopoietic stem and progenitor cells

Hosuru, R. V., Yang, J., Zhou, Y.-F., Gin, A. L., Hayal, T. B., Hong, S. G., Dunbar, C. E., & Wu, C. (2024) · British Journal of Haematology · doi:10.1111/bjh.19889 · Cited by 4 · see citing works

Aging of hematopoietic stem cells: Insight into mechanisms and consequences

Chatterjee, B., & Thakur, S. S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820071-1.00016-5 · Cited by 4 · see citing works

Analysis of the dynamic changes in the proportion of immune cells and the proportion of cells with stem cell characteristics in the corresponding immune cell population of C57 mice during the natural aging process

Luan, J., Xu, H. Y., Zhang, J., Guan, H., Gao, X., Gou, X., & Xu, L. (2021) · Immunologic Research · doi:10.1007/s12026-021-09229-w · Cited by 4 · see citing works

An inflammatory and quiescent HSC subpopulation expands with age in humans

Safina, K. R., Salik, B., Kotliar, D., Curtis, M. L., Good, J., Weng, C., David, S., Raychaudhuri, S., Kreso, A., Trowbridge, J. J., et al. (2026) · Genome biology · doi:10.1186/s13059-026-03936-z · Cited by 2 · see citing works

Advancing Single-Cell Detection of Senescent Cells: Laboratory Methods and Clinical Applications

Lung, S. H., & Lung, T. (2025) · OBM Geriatrics · doi:10.21926/obm.geriatr.2502307 · Cited by 3 · see citing works

Aging of the adaptive immune system affects the gut microbiome and systemic levels of vitamin B6

Stahl, S., Widmaier, H., Sakk, V., Nalapareddy, K., Kissmann, A., Rosenau, F., Mulaw, M. A., Haslam, D. B., & Geiger, H. (2026) · Microbiome · doi:10.1186/s40168-026-02428-3 · Cited by 2 · see citing works

Mouse Hematopoietic Stem Cell Transplantation

Yuan, S., Liu, B., & Huang, W. (2022) · Springer eBooks · doi:10.1007/978-981-19-6111-3_17 · Cited by 1 · see citing works

The role of the Rho family small GTPases in regulation of normal and pathological processes

Bobkov, D. E., Lukacheva, A., Gorb, A. I., & Poljanskaya, G. G. (2024) · Tsitologiya · doi:10.31857/s0041377124010012 · Cited by 1 · see citing works

Old hematopoietic stem cells retain competence to reconstitute a youthful B cell system that is highly responsive to protein-based vaccination

Kunath, P., Pflumm, D., Moehrle, B., Sakk, V., Seidel, A., Münch, J., Geiger, H., & Schirmbeck, R. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00507-x · Cited by 1 · see citing works

Harnessing Distinct Tissue-Resident Immune Niches via S100A9/TLR4 Improves Ketone, Lipid, and Glucose Metabolism

Lucibello, G., Ursino, G., Teixeira, P. D. S., Zahorán, S., Fanuele, F., Kallikourdis, M., Visentin, F., Veyrat‐Durebex, C., Widmer, A., Wu, Y., et al. (2025) · Endocrinology · doi:10.1210/endocr/bqaf131 · Cited by 1 · see citing works

Age-related changes in the hematopoietic stem cell pool revealed via quantifying the balance of symmetric and asymmetric divisions

Kawahigashi, T., Iwanami, S., Takahashi, M., Bhadury, J., Iwami, S., & Yamazaki, S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0292575 · Cited by 2 · see citing works

Immunology of Ageing

Pawelec, G., & Müller, L. (2024) · Springer eBooks · doi:10.1007/978-3-030-74720-6_104 · Cited by 1 · see citing works

Restoration of Aged Hematopoietic Cells by Their Young Counterparts Through Instructive Microvesicle ReleasePreprint

Greco, S. J., Ayer, S., Guiro, K., Sinha, G., DONNELLY, R. J., El-Far, M. H., Sherman, L. S., Pamarthi, S. H., Gergues, M., Sandiford, O. A., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3862822

Immunology of Ageing

Pawelec, G., & Müller, L. (2021) · Springer eBooks · doi:10.1007/978-3-030-01782-8_104-1

Multiple thymi and no thymic involution in naked mole rats?

Pawelec, G. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00253-w

Age-related changes in the haematopoietic stem cell pool revealed via quantifying the balance of symmetric and asymmetric divisions.Preprint

Kawahigashi, T., Iwanami, S., Takahashi, M., Bhadury, J., Iwami, S., & Yamazaki, S. (2022) · Research Square · doi:10.21203/rs.3.rs-2300063/v1

Advances in the study of exercise to delay immune aging

Niu, Y.-M., & Shi, C.-L. (2024) · New discovery. · doi:10.61958/ndph7343

Research progress of immune cell senescence and anti-senescence strategy with exercise

Dong, X., & Cai, X.-X. (2024) · New cell · doi:10.61958/nchz1574

Stem-Cell Therapy for Anti-Aging

Sureshkumar, T., Krishnasreya, M., Elakkiya, M. R., Saraswathy, C. D. B., & Moin, S. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-9730-5.ch006

UPS delivers apolarity and senescence to HSCs

Geiger, H. (2025) · Blood · doi:10.1182/blood.2025030420

Hematopoietic (stem) cells—The elixir of life?

Cerezo, E. L., Anderson, J., Vedrenne, E. D., Martín, N. Y., & Lengefeld, J. (2025) · FEBS Letters · doi:10.1002/1873-3468.70215

The extent of myeloid skewing in blood is a biomarker of biological aging in mice and humansPreprint

Niemann, J., Stahl, S., Sakk, V., Perez-Correa, J.-F., Wagner, W., Jaensch, A., Rothenbacher, D., Zheng, Y., Mulaw, M. A., Geiger, H., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.20.700344

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

He, H., & Wang, J. (2026) · Aging and Cancer · doi:10.1002/aac2.70016

Étude de l'inflammation et de la sénescence impliquées dans la fragilité musculaire associée au Syndrome de Noonan

Mazeyrie, L. (2024) · theses.fr (ABES) · doi:10.70675/04dabd62z8f26z4393zac25z0070faaa4fb9

Hematopoietic Stem Cell Metabolism during Stress and Aging

Sharma, D., & Filippi, M. (2026) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20260018

Integrated Analysis of Hematopoietic Changes Following Heterochronic Bone Marrow Transplantation Between Young and Aged Mice

Bejarano-García, J. A., Nufer, M., Caracuel-García, R., Caballero‐Velázquez, T., Gil, A. R., Jimenes, A. J., Muñoz, R., Piruat, J. I., & Pérez‐Simón, J. A. (2026) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2026.09.011

Targeting BIRC6 rejuvenates hematopoietic stem cell aging and immunosenescence

Liao, W., Shao, F., Wang, S., Wang, Y., Chen, X., Zhang, Y., Zhang, Z., Zai, X., Yang, Y., Yin, Y., et al. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02787-1

RESTORING YOUTHFUL CELLULAR IMMUNITY BY REJUVENATION OF AGED HEMATOPOIETIC STEM CELLS

Leins, H., Denkinger, M. D., Schirmbeck, R., & Geiger, H. (2017) · Innovation in Aging · doi:10.1093/geroni/igx004.2037

Lymphohematopoietic Stem Cells and Their Aging

Leins, H., & Geiger, H. (2018) · Springer eBooks · doi:10.1007/978-3-319-64597-1_30-1

CASIN the joint: immune aging at the stem cell level

Pawelec, G. (2018) · Blood · doi:10.1182/blood-2018-06-858696 · Cited by 7 · see citing works

HSC Aging and Senescent Immune Remodeling

Denkinger, M. D., Leins, H., Schirmbeck, R., Florian, M. C., & Geiger, H. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.10.008 · Cited by 105 · see citing works

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

Wahlestedt, M., Norddahl, G. L., Sten, G., Ugale, A., Frisk, M.-A. M., Mattsson, R., Deierborg, T., Sigvardsson, M., & Bryder, D. (2013) · Blood · doi:10.1182/blood-2012-11-469080 · Cited by 106 · see citing works