Cited by 882Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

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Cross-Presentation, Dendritic Cells, Tolerance and Immunity

Heath, William R., Carbone, Francis R.·2001·Annual Review of Immunology

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Abstract

This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.

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Crossref · 10.1146/annurev.immunol.19.1.47

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Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,496
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631
A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
Medzhitov, R., Preston-Hurlburt, P., & Janeway, C. A. J. (1997) · Nature · doi:10.1038/41131 · Cited by 6,137
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848
T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions
Schoenberger, S. P., Toes, R. E. M., van der Voort, E. I. H., Offringa, R., & Melief, C. J. M. (1998) · Nature · doi:10.1038/31002 · Cited by 2,615
Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.
Sallusto, F., Cella, M., Danieli, C., & Lanzavecchia, A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.2.389 · Cited by 2,501
IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE
Steinman, R. M., & Cohn, Z. A. (1973) · The Journal of Experimental Medicine · doi:10.1084/jem.137.5.1142 · Cited by 2,443
Innate Immunity: The Virtues of a Nonclonal System of Recognition
Medzhitov, R., & Janeway, C. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80412-2 · Cited by 2,434
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell
Ridge, J. P., Rosa, F. D., & Matzinger, P. (1998) · Nature · doi:10.1038/30989 · Cited by 2,360
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
Albert, M. L., Sauter, B., & Bhardwaj, N. (1998) · Nature · doi:10.1038/32183 · Cited by 2,350

Show all 92 references

Research works printed but not linked: 2

Ansorge S, 1984, Biomed. Biochim. Acta, 43, 1213
Miceli MV, 1999, Invest. Ophthalmol. Visual Sci., 40, 1238

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Rodolfo, M., Luksch, R., Stockert, E., Chen, Y., Collini, P., Ranzani, T., Lombardo, C., Dalerba, P. D., Rivoltini, L., Arienti, F., et al. (2003) · PubMed · Cited by 67
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Authors: Heath, W. R., & Carbone, F. R.
Affiliations: The Royal Melbourne Hospital (AU)
Immunology Division, The Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, Parkville, Victoria 3052, Australia;
ORCID: Heath, William R.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2001-04
Volume: 19
Issue: 1
Pages: 47-64
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.19.1.47
OpenAlex: W2107140931
Cited by: 882
References: 92
Citations by year: 2026: 2 · 2025: 7 · 2024: 10 · 2023: 12 · 2022: 9 · 2021: 6 · 2020: 10 · 2019: 11 · 2018: 18 · 2017: 23 · 2016: 26 · 2015: 19 · 2014: 20 · 2013: 21 · 2012: 23
FWCI: 8.09
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: cross-presentation, dendritic cells, cross-priming, antigen presentation, immune tolerance, antigen-presenting cells, molecular signals
MeSH terms: Animals, Dendritic Cells, Histocompatibility Antigens, HLA Antigens, Humans, Immune Tolerance, Immunity, Macrophages, Mice, Transgenic, T-Lymphocyte Subsets, Antigen Presentation, Mice

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