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Cross-Presentation, Dendritic Cells, Tolerance and Immunity
Abstract
This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.
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“Perhaps paradoxically, tolerance induction by apoptotic cells depends on MHC class I molecules and involves immune suppression by CD8+ T cells10,24,25.”
From Immunogenic and tolerogenic cell death (2009) · cites this paper as [25]
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Santos, K., Simon, D. A. L., Conway, E., Bowers, W. J., Mitra, S., Foster, T. H., Lugade, A. A., Lord, E. M., Federoff, H. J., Dewhurst, S., et al. (2007) · Human Gene Therapy · doi:10.1089/hum.2006.082 · Cited by 13
Metadata
- Authors
- Heath, W. R., & Carbone, F. R.
- Affiliations
- The Royal Melbourne Hospital (AU)
- Immunology Division, The Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, Parkville, Victoria 3052, Australia;
- ORCID
- Heath, William R.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2001-04
- Volume
- 19
- Issue
- 1
- Pages
- 47-64
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2107140931
- Cited by
- 882
- References
- 92
- Citations by year
- 2026: 2 · 2025: 7 · 2024: 10 · 2023: 12 · 2022: 9 · 2021: 6 · 2020: 10 · 2019: 11 · 2018: 18 · 2017: 23 · 2016: 26 · 2015: 19 · 2014: 20 · 2013: 21 · 2012: 23
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- cross-presentation, dendritic cells, cross-priming, antigen presentation, immune tolerance, antigen-presenting cells, molecular signals
- MeSH terms
- Animals, Dendritic Cells, Histocompatibility Antigens, HLA Antigens, Humans, Immune Tolerance, Immunity, Macrophages, Mice, Transgenic, T-Lymphocyte Subsets, Antigen Presentation, Mice
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