Cross-Presentation, Dendritic Cells, Tolerance and Immunity

Dendritic cells and the control of immunity

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Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

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Tolerance, Danger, and the Extended Family

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T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

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Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

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IDENTIFICATION OF A NOVEL CELL TYPE IN PERIPHERAL LYMPHOID ORGANS OF MICE

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Innate Immunity: The Virtues of a Nonclonal System of Recognition

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A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

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Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

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Tolerogenic Dendritic Cells

Steinman, R. M., Hawiger, D., & Nussenzweig, M. C. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141040 · Cited by 3,162

Mouse and human dendritic cell subtypes

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Dendritic Cells

Mellman, I., & Steinman, R. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00449-4 · Cited by 2,256

Cancer immunotherapy via dendritic cells

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Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo

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In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.

Jung, S., Unutmaz, D., Wong, P., Sano, G., Santos, K. D. L., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00365-5 · Cited by 1,953

The Liver as an Immunological Organ

Racanelli, V., & Rehermann, B. (2006) · Hepatology · doi:10.1002/hep.21060 · Cited by 1,377

Immunogenic and tolerogenic cell death

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Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance

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CD8+ T cell differentiation and dysfunction in cancer

Philip, M., & Schietinger, A. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-021-00574-3 · Cited by 1,052

Regulation of T Cell Immunity by Dendritic Cells

Lanzavecchia, A., & Sallusto, F. (2001) · Cell · doi:10.1016/s0092-8674(01)00455-x · Cited by 997

Cross-priming of CD8+ T cells stimulated by virus-induced type I interferon

Bon, A. L., Etchart, N., Rossmann, C., Ashton, M., Hou, S., Gewert, D. R., Borrow, P., & Tough, D. F. (2003) · Nature Immunology · doi:10.1038/ni978 · Cited by 816

ER–phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

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A CENTRAL ROLE FOR CENTRAL TOLERANCE

Kyewski, B., & Klein, L. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115601 · Cited by 768

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

Schietinger, A., & Greenberg, P. D. (2013) · Trends in Immunology · doi:10.1016/j.it.2013.10.001 · Cited by 704

Dendritic cell subsets in cancer immunity and tumor antigen sensing

Prete, A. D., Salvi, V., Soriani, A., Laffranchi, M., Sozio, F., Bosisio, D., & Sozzani, S. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00990-6 · Cited by 682

Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease

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Microbial Stimulation Fully Differentiates Monocytes to DC-SIGN/CD209+ Dendritic Cells for Immune T Cell Areas

Cheong, C., de Matos, I. G., Choi, J., Dandamudi, D. B., Shrestha, E., Longhi, M. P., Jeffrey, K. L., Anthony, R. M., Kluger, C., Nchinda, G., et al. (2010) · Cell · doi:10.1016/j.cell.2010.09.039 · Cited by 640

The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation

Fujii, S., Liu, K., Smith, C., Bonito, A., & Steinman, R. (2004) · Journal of Experimental Medicine · doi:10.1084/jem.20040317 · Cited by 647

Signals required for programming effector and memory development by CD8+ T cells

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Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines

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Shaping and reshaping CD8+ T-cell memory

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Tumour immunity: effector response to tumour and role of the microenvironment

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Targeting tumours with genetically enhanced T lymphocytes

Sadelain, M., Rivière, I., & Brentjens, R. J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc971 · Cited by 541

T Cell Memory

Sprent, J., & Surh, C. D. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100101.151926 · Cited by 539

Mucosal Dendritic Cells

Iwasaki, A. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141634 · Cited by 555

Involvement of LOX-1 in Dendritic Cell-Mediated Antigen Cross-Presentation

Delneste, Y., Magistrelli, G., Gauchat, J., Haeuw, J., Aubry, J., Nakamura, K., Kawakami, N., Goetsch, L., Sawamura, T., Bonnefoy, J., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00388-6 · Cited by 529

Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells

Curtsinger, J., Lins, D. C., & Mescher, M. F. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021910 · Cited by 510

Progressive differentiation and selection of the fittest in the immune response

Lanzavecchia, A., & Sallusto, F. (2002) · Nature Reviews Immunology · doi:10.1038/nri959 · Cited by 495

Cross-presentation in viral immunity and self-tolerance

Heath, W. R., & Carbone, F. (2001) · Nature reviews. Immunology · doi:10.1038/35100512 · Cited by 480

Induction of tumor cell apoptosis in vivo increases tumor antigen cross-presentation, cross-priming rather than cross-tolerizing host tumor-specific CD8 T cells

Nowak, A. K., Lake, R. A., Marzo, A. L., Scott, B., Heath, W. R., Collins, E. J., Frelinger, J. A., & Robinson, B. W. S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.4905 · Cited by 463

The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens

Belz, G. T., Behrens, G. M. N., Smith, C. M., Miller, J. F. A. P., Jones, C. M., Lejon, K., Fathman, C. G., Mueller, S. N., Shortman, K., Carbone, F., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020861 · Cited by 467

Zoned Out: Functional Mapping of Stromal Signaling Microenvironments in the Thymus

Petrie, H. T., & Zúñiga-Pflücker, J. C. (2007) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115715 · Cited by 454

Recent Advances in Hyperthermia Therapy‐Based Synergistic Immunotherapy

Chang, M., Hou, Z., Wang, M., Li, C., & Lin, J. (2020) · Advanced Materials · doi:10.1002/adma.202004788 · Cited by 457

Cross‐presentation: underlying mechanisms and role in immune surveillance

Rock, K. L., & Shen, L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00301.x · Cited by 469

Dying cells actively regulate adaptive immune responses

Yatim, N., Cullen, S., & Albert, M. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.9 · Cited by 442

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection

Badovinac, V. P., Haring, J. S., & Harty, J. T. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.013 · Cited by 406

Accelerated CD8+ T-cell memory and prime-boost response after dendritic-cell vaccination

Badovinac, V. P., Messingham, K. N., Jabbari, A., Haring, J. S., & Harty, J. T. (2005) · Nature Medicine · doi:10.1038/nm1257 · Cited by 403

Dynamic programming of CD8+ T lymphocyte responses

van Stipdonk, M. J. B., Hardenberg, G., Bijker, M. S., Lemmens, E. E., Droin, N. M., Green, D. R., & Schoenberger, S. P. (2003) · Nature Immunology · doi:10.1038/ni912 · Cited by 401

Immunopathogenic mechanisms in psoriasis

Gudjonsson, J. E., Johnston, A. W. B., Sigmundsdóttir, H., & Valdimarsson, H. (2003) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02310.x · Cited by 398

Important Role of Cathepsin S in Generating Peptides for TAP-Independent MHC Class I Crosspresentation In Vivo

Shen, L., Sigal, L. J., Boes, M. L., & Rock, K. L. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.004 · Cited by 391

Dendritic Cell Development and Survival Require Distinct NF-κB Subunits

Ouaaz, F., Arron, J. R., Zheng, Y., Choi, Y., & Beg, A. A. (2002) · Immunity · doi:10.1016/s1074-7613(02)00272-8 · Cited by 389

Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis

Schiavoni, G., Sistigu, A., Valentini, M., Mattei, F., Sestili, P., Spadaro, F., Sanchez, M., Lorenzi, S., D'Urso, M. T., Belardelli, F., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2788 · Cited by 362

Apoptosis: Programmed cell death at a molecular level

Schultz, D. R., & Harringto, W. J. (2003) · Seminars in Arthritis and Rheumatism · doi:10.1053/sarh.2003.50005 · Cited by 358

Peripheral antigen display by lymph node stroma promotes T cell tolerance to intestinal self

Lee, J., Epardaud, M., Sun, J., Becker, J. E., Cheng, A. C., Yonekura, A.-R., Heath, J. K., & Turley, S. J. (2006) · Nature Immunology · doi:10.1038/ni1427 · Cited by 368

A nanovaccine for antigen self-presentation and immunosuppression reversal as a personalized cancer immunotherapy strategy

Liu, C., Liu, X., Xiang, X., Pang, X., Chen, S., Zhang, Y., Ren, E., Zhang, L., Liu, X., Lv, P., et al. (2022) · Nature Nanotechnology · doi:10.1038/s41565-022-01098-0 · Cited by 364

Antitumor Monoclonal Antibodies Enhance Cross-Presentation of Cellular Antigens and the Generation of Myeloma-specific Killer T Cells by Dendritic Cells

Dhodapkar, K. M., Krasovsky, J., Williamson, B., & Dhodapkar, M. V. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011097 · Cited by 348

Memory CD8+ T Cells Provide Innate Immune Protection against Listeria monocytogenes in the Absence of Cognate Antigen

Berg, R. E., Crossley, E. C., Murray, S. E., & Forman, J. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20031051 · Cited by 352

Mesothelin-specific CD8+ T Cell Responses Provide Evidence of In Vivo Cross-Priming by Antigen-Presenting Cells in Vaccinated Pancreatic Cancer Patients

Thomas, A. M., SANTARSIERO, L., Lutz, E. R., Armstrong, T. D., Chen, Y.-C., Huang, L.-Q., Laheru, D. A., Goggins, M., Hruban, R. H., & Jaffee, E. M. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031435 · Cited by 347

Alpha-alumina nanoparticles induce efficient autophagy-dependent cross-presentation and potent antitumour response

Li, H., Li, Y., Jiao, J., & Hu, H. (2011) · Nature Nanotechnology · doi:10.1038/nnano.2011.153 · Cited by 347

Protein degradation and the generation of MHC class I-presented peptides

Rock, K. L., York, I. A., Šarić, T., & Goldberg, A. L. (2002) · Advances in immunology · doi:10.1016/s0065-2776(02)80012-8 · Cited by 342

Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development

Aspord, C., Pedroza‐González, A., Gallegos, M., Tindle, S., Burton, E. C., Su, D., Marches, F., Banchereau, J., & Palucka, A. K. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061120 · Cited by 356

The Yin and Yang of Toll-like receptors in cancer

Pradère, J., Dapito, D. H., & Schwabe, R. F. (2013) · Oncogene · doi:10.1038/onc.2013.302 · Cited by 345

Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells

Engelhardt, J., Boldajipour, B. A., Beemiller, P., Pandurangi, P., Sorensen, C. M., Werb, Z., Egeblad, M., & Krummel, M. F. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.008 · Cited by 347

NADPH oxidase controls phagosomal pH and antigen cross-presentation in human dendritic cells

Mantegazza, A. R., Savina, A., Vermeulen, M., Pérez, L., Geffner, J., Hermine, O., Rosenzweig, S. D., Faure, F., & Amigorena, S. (2008) · Blood · doi:10.1182/blood-2008-01-134791 · Cited by 329

Design considerations for liposomal vaccines: Influence of formulation parameters on antibody and cell-mediated immune responses to liposome associated antigens

Watson, D. S., Endsley, A. N., & Huang, L. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.01.070 · Cited by 339

CD103− and CD103+ Bronchial Lymph Node Dendritic Cells Are Specialized in Presenting and Cross-Presenting Innocuous Antigen to CD4+ and CD8+ T Cells

del Rio, M., Rodríguez-Barbosa, J.-I., Kremmer, E., & Förster, R. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.6861 · Cited by 319

Immunity in response to particulate antigen-delivery systems

Storni, T., Kündig, T. M., Senti, G., & Johansen, P. (2004) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2004.09.008 · Cited by 315

On regulation of phagosome maturation and antigen presentation

Blander, J. M., & Medzhitov, R. M. (2006) · Nature Immunology · doi:10.1038/ni1006-1029 · Cited by 317

T cell homeostatic proliferation elicits effective antitumor autoimmunity

Dummer, W., Niethammer, A. G., Baccalà, R., Lawson, B. R., Wagner, N., Reisfeld, R. A., & Theofilopoulos, A. N. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15175 · Cited by 316

Monoclonal antibodies for cancer immunotherapy

Weiner, L. M., Dhodapkar, M. V., & Ferrone, S. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60251-8 · Cited by 312

Efficient Cross-presentation Depends on Autophagy in Tumor Cells

Li, Y., Wang, L., Yang, G., Fang, H., Urba, W. J., & Hu, H. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0161 · Cited by 302

A Subset of Toll-Like Receptor Ligands Induces Cross-presentation by Bone Marrow-Derived Dendritic Cells

Datta, S. K., Redecke, V., Prilliman, K. R., Takabayashi, K., Corr, M., Tallant, T. C., DiDonato, J. A., Dziarski, R., Akira, S., Schoenberger, S. P., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4102 · Cited by 309

Targeting dendritic cells with nano-particulate PLGA cancer vaccine formulations

Hamdy, S. I., Haddadi, A., Hung, R., & Lavasanifar, A. (2011) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.05.021 · Cited by 301

Current Developments in Cancer Vaccines and Cellular Immunotherapy

Ribas, A., Butterfield, L. H., Glaspy, J. A., & Economou, J. S. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.06.041 · Cited by 293

The Immune Revolution: A Case for Priming, Not Checkpoint

Vonderheide, R. H. (2018) · Cancer Cell · doi:10.1016/j.ccell.2018.03.008 · Cited by 301

Autoimmunity through Cytokine-Induced Dendritic Cell Activation

Banchereau, J., Pascual, V., & Palucka, A. K. (2004) · Immunity · doi:10.1016/s1074-7613(04)00108-6 · Cited by 295

Generation of effector CD8 + T cells and their conversion to memory T cells

Cui, W., & Kaech, S. M. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00926.x · Cited by 299

Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

Millar, D. G., Garza, K. M., Odermatt, B., Elford, A. R., Ono, N., Li, Z., & Ohashi, P. S. (2003) · Nature Medicine · doi:10.1038/nm962 · Cited by 290

Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies

Ponce, R. A., Abad, L. W., Amaravadi, L. S., Gelzleichter, T. R., Gore, E. R., Green, J., Gupta, S., Herzyk, D. J., Hurst, C. H., Ivens, I. A., et al. (2009) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2009.03.012 · Cited by 271

T cell homeostatic proliferation elicits effective antitumor autoimmunity

Dummer, W., Niethammer, A. G., Baccalà, R., Lawson, B. R., Wagner, N., Reisfeld, R. A., & Theofilopoulos, A. N. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215175 · Cited by 267

Immune complex–mediated antigen presentation induces tumor immunity

Rafiq, K., Bergtold, A., & Clynes, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15640 · Cited by 266

Development and functional specialization of CD103+ dendritic cells

del Rio, M., Bernhardt, G., Rodríguez-Barbosa, J.-I., & Förster, R. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2009.00874.x · Cited by 274

HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation

Granelli‐Piperno, A., Golebiowska, A., Trumpfheller, C., Siegal, F. P., & Steinman, R. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402431101 · Cited by 260

IDO and tolerance to tumors

Munn, D. H., & Mellor, A. L. (2003) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2003.11.003 · Cited by 257

Both Dendritic Cells and Macrophages Can Stimulate Naive CD8 T Cells In Vivo to Proliferate, Develop Effector Function, and Differentiate into Memory Cells

Pozzi, L.-A. M., Maciaszek, J. W., & Rock, K. L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.4.2071 · Cited by 258

Inflaming the CD8+ T Cell Response

Haring, J. S., Badovinac, V. P., & Harty, J. T. (2006) · Immunity · doi:10.1016/j.immuni.2006.07.001 · Cited by 264

Integrin‐Mediated Interactions Control Macrophage Polarization in 3D Hydrogels

Cha, B., Shin, S. R., Leijten, J., Li, Y., Singh, S., Liu, J. C., Annabi, N., Abdi, R., Dokmeci, M. R., Vrana, N. E., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700289 · Cited by 256

Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?

Friese, M. A., & Fugger, L. H. (2005) · Brain · doi:10.1093/brain/awh578 · Cited by 251

Rapamycin-Treated, Alloantigen-Pulsed Host Dendritic Cells Induce Ag-Specific T Cell Regulation and Prolong Graft Survival

Taner, T., Hackstein, H., Wang, Z., Morelli, A. E., & Thomson, A. W. (2005) · American Journal of Transplantation · doi:10.1046/j.1600-6143.2004.00673.x · Cited by 250

Langerhans cells – dendritic cells of the epidermis

Romani, N., Holzmann, S., Tripp, C. H., Koch, F., & Stoitzner, P. (2003) · Apmis · doi:10.1034/j.1600-0463.2003.11107805.x · Cited by 259

Presentation of Exogenous Antigens on Major Histocompatibility Complex (MHC) Class I and MHC Class II Molecules Is Differentially Regulated during Dendritic Cell Maturation

Delamarre, L., Holcombe, H. R., & Mellman, I. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021542 · Cited by 247

T‐cell tolerance or function is determined by combinatorial costimulatory signals

Nurieva, R., Thomas, S., Nguyen, T. D., Martín‐Orozco, N., Wang, Y., Murali‐Krishna, K., Yu, X., & Dong, C. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601146 · Cited by 250

Selective blockade of inhibitory Fcγ receptor enables human dendritic cell maturation with IL-12p70 production and immunity to antibody-coated tumor cells

Dhodapkar, K. M., Kaufman, J. L., Ehlers, M., Banerjee, D. K., Bonvini, E., Koenig, S., Steinman, R. M., Ravetch, J. V., & Dhodapkar, M. V. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500014102 · Cited by 247

Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cells

Cools, N., Ponsaerts, P., Tendeloo, V. F. V., & Berneman, Z. N. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0307166 · Cited by 238

The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria

Stagg, A. J., Hart, A. L., Knight, S. C., & Kamm, M. A. (2003) · Gut · doi:10.1136/gut.52.10.1522 · Cited by 237

Immune complex–mediated antigen presentation induces tumor immunity

Rafiq, K., Bergtold, A., & Clynes, R. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215640 · Cited by 232

Peripheral Tolerance of CD8 T Lymphocytes

Redmond, W. L., & Sherman, L. A. (2005) · Immunity · doi:10.1016/j.immuni.2005.01.010 · Cited by 234

Chloroquine enhances human CD8 + T cell responses against soluble antigens in vivo

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Langerhans cells cross-present antigen derived from skin

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