Cited by 882Immunotherapy and Immune ResponsesT-cell and B-cell ImmunologyImmune Response and Inflammation

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Cross-Presentation, Dendritic Cells, Tolerance and Immunity

Heath, William R., Carbone, Francis R.·2001·Annual Review of Immunology

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Abstract

This review examines the role of cross-presentation in tolerance and immunity. We discuss (a) the antigenic requirements for cross-presentation, (b) the phenotype of the antigen presenting cell (APC), (c) the cellular interactions and molecular signals involved in cross-priming, and (d) the factors that direct the immune system toward tolerance or immunity. A large part of this review is dedicated to summarizing our current knowledge of the cross-presenting APC.

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Crossref · 10.1146/annurev.immunol.19.1.47

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Authors: Heath, W. R., & Carbone, F. R.
Affiliations: The Royal Melbourne Hospital (AU)
Immunology Division, The Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, Parkville, Victoria 3052, Australia;
ORCID: Heath, William R.
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2001-04
Volume: 19
Issue: 1
Pages: 47-64
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev.immunol.19.1.47
OpenAlex: W2107140931
Cited by: 882
References: 92
Citations by year: 2026: 2 · 2025: 7 · 2024: 10 · 2023: 12 · 2022: 9 · 2021: 6 · 2020: 10 · 2019: 11 · 2018: 18 · 2017: 23 · 2016: 26 · 2015: 19 · 2014: 20 · 2013: 21 · 2012: 23
FWCI: 8.09
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: cross-presentation, dendritic cells, cross-priming, antigen presentation, immune tolerance, antigen-presenting cells, molecular signals
MeSH terms: Animals, Dendritic Cells, Histocompatibility Antigens, HLA Antigens, Humans, Immune Tolerance, Immunity, Macrophages, Mice, Transgenic, T-Lymphocyte Subsets, Antigen Presentation, Mice

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