The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
HOW TCRS BIND MHCS, PEPTIDES, AND CORECEPTORS
Abstract
Since the first crystal structure determinations of αβ T cell receptors (TCRs) bound to class I MHC-peptide (pMHC) antigens in 1996, a sizable database of 24 class I and class II TCR/pMHC complexes has been accumulated that now defines a substantial degree of structural variability in TCR/pMHC recognition. Recent determination of free and bound γδ TCR structures has enabled comparisons of the modes of antigen recognition by αβ and γδ T cells and antibodies. Crystal structures of TCR accessory (CD4, CD8) and coreceptor molecules (CD3ɛδ, CD3ɛγ) have further advanced our structural understanding of most of the components that constitute the TCR signaling complex. Despite all these efforts, the structural basis for MHC restriction and signaling remains elusive as no structural features that define a common binding mode or signaling mechanism have yet been gleaned from the current set of TCR/pMHC complexes. Notwithstanding, the impressive array of self, foreign (microbial), and autoimmune TCR complexes have uncovered the diverse ways in which antigens can be specifically recognized by TCRs.
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Cites
Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature · doi:10.1038/329512a0 · Cited by 2,377
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Robins, H. S., Campregher, P. V., Srivastava, S. K., Wacher, A., Turtle, C. J., Kahsai, O., Riddell, S. R., Warren, E. H., & Carlson, C. S. (2009) · Blood · doi:10.1182/blood-2009-04-217604 · Cited by 1,122
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Yadav, M., Jhunjhunwala, S., Phung, Q. T., Lupardus, P., Tanguay, J., Bumbaca, S., Franci, C., Cheung, T. K., Fritsche, J., Weinschenk, T., et al. (2014) · Nature · doi:10.1038/nature14001 · Cited by 1,186
Identifying specificity groups in the T cell receptor repertoire
Glanville, J., Huang, H., Nau, A., Hatton, O., Wagar, L. E., Rubelt, F., Ji, X., Han, A., Krams, S. M., Pettus, C., et al. (2017) · Nature · doi:10.1038/nature22976 · Cited by 1,026
CD19 CAR T cell product and disease attributes predict leukemia remission durability
Finney, O. C., Brakke, H., Rawlings-Rhea, S., Hicks, R., Doolittle, D., Lopez, M., Futrell, B., Orentas, R. J., Li, D., Gardner, R., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125423 · Cited by 346
Singh, M., Al-Eryani, G., Carswell, S., Ferguson, J. M., Blackburn, J., Barton, K., Roden, D., Luciani, F., Giang Phan, T., Junankar, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11049-4 · Cited by 308
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Chowell, D., Krishna, S., Becker, P. D., Cocita, C., Shu, J., Tan, X., Greenberg, P. D., Klavinskis, L. S., Blattman, J. N., & Anderson, K. S. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500973112 · Cited by 239
Bioinformatic and Statistical Analysis of Adaptive Immune Repertoires
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Li, G., Iyer, B., Prasath, V. B. S., Ni, Y., & Salomonis, N. (2021) · Briefings in Bioinformatics · doi:10.1093/bib/bbab160 · Cited by 168
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Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination
Brazin, K. N., Mallis, R. J., Das, D. K., Feng, Y., Hwang, W., Wang, J.-H., Wagner, G., Lang, M. J., & Reinherz, E. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00441 · Cited by 70
Wu, D., Yin, R., Chen, G., Ribeiro-Filho, H. V., Cheung, M., Robbins, P. F., Mariuzza, R. A., & Pierce, B. G. (2024) · Science Advances · doi:10.1126/sciadv.adq6150 · Cited by 27
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Quantifying conformational changes in the TCR:pMHC-I binding interface
McMaster, B., Thorpe, C. J., Rossjohn, J., Deane, C. M., & Koohy, H. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1491656 · Cited by 17
Thioamide Analogues of MHC I Antigen Peptides
Gibadullin, R., Morris, R. K., Niu, J., Sidney, J., Sette, A., & Gellman, S. H. (2023) · Journal of the American Chemical Society · doi:10.1021/jacs.3c05300 · Cited by 17
Gunnarsen, K. S., Høydahl, L. S., Neumann, R. S., Bjerregaard-Andersen, K., Nilssen, N. R., Sollid, L. M., Sandlie, I., & Løset, G. Å. (2018) · PLOS ONE · doi:10.1371/journal.pone.0195868 · Cited by 15
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Metadata
- Authors
- Rudolph, M. G., Stanfield, R. L., & Wilson, I. A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2006-04-01
- Volume
- 24
- Issue
- 1
- Pages
- 419-466
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2146074801
- Cited by
- 1,310
- References
- 1
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- closed
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