TCR-signaling events in cellular metabolism and specialization

Modulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis

Meijer, L., Nelson, D. J., Riazanski, V., Gabdoulkhakova, A. G., Héry-Arnaud, G., Berre, R. L., Loaëc, N., Oumata, N., Galons, H., Nowak, E., et al. (2016) · Journal of Innate Immunity · doi:10.1159/000444256 · Cited by 4,992 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 4× · see citing works

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works

Metabolic Pathways in Immune Cell Activation and Quiescence

Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692 · see citing works

Transcriptional control of effector and memory CD8+ T cell differentiation

Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628 · see citing works

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Pearce, E. L., Walsh, M. C., Cejas, P. J., Harms, G. M., Shen, H., Wang, L.-S., Jones, R. G., & Choi, Y. (2009) · Nature · doi:10.1038/nature08097 · Cited by 1,559 · see citing works

Plasticity of CD4+ T Cell Lineage Differentiation

Zhou, L., Chong, M. M. W., & Littman, D. R. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.001 · Cited by 1,551 · see citing works

Metabolic pathways promoting cancer cell survival and growth

Boroughs, L. K., & DeBerardinis, R. J. (2015) · Nature Cell Biology · doi:10.1038/ncb3124 · Cited by 1,459 · see citing works

Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4 + T Cells

O’Shea, J. J., & Paul, W. E. (2010) · Science · doi:10.1126/science.1178334 · Cited by 1,341 · see citing works

HOW TCRS BIND MHCS, PEPTIDES, AND CORECEPTORS

Rudolph, M. G., Stanfield, R. L., & Wilson, I. A. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115658 · Cited by 1,314 · see citing works

A Validated Regulatory Network for Th17 Cell Specification

Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkurst, C. N., Muratet, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.016 · Cited by 1,160 · see citing works

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

Pipkin, M. E., Sacks, J. A., Cruz‐Guilloty, F., Lichtenheld, M. G., Bevan, M. J., & Rao, A. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.012 · Cited by 799 · see citing works

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen

Doedens, A. L., Phan, A. T., Stradner, M. H., Fujimoto, J. K., Nguyen, J. V., Yang, E., Johnson, R. S., & Goldrath, A. W. (2013) · Nature Immunology · doi:10.1038/ni.2714 · Cited by 660 · see citing works

Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral Infection

Kaech, S. M., & Wherry, E. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.007 · Cited by 619 · see citing works

Inflammatory cytokines as a third signal for T cell activation

Curtsinger, J., & Mescher, M. F. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.02.013 · Cited by 618 · see citing works

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells

Finlay, D. K., Rosenzweig, E., Sinclair, L. V., Feijoo-Carnero, C., Hukelmann, J. L., Rolf, J., Panteleyev, A. A., Okkenhaug, K., & Cantrell, D. A. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112607 · Cited by 596 · see citing works

Molecular regulation of effector and memory T cell differentiation

Chang, J. T., Wherry, E. J., & Goldrath, A. W. (2014) · Nature Immunology · doi:10.1038/ni.3031 · Cited by 578 · see citing works

Sterol regulatory element–binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

Kidani, Y., Elsaesser, H., Hock, M. B., Vergnes, L., Williams, K. J., Argus, J. P., Marbois, B. N., Komisopoulou, E., Wilson, E. B., Osborne, T. F., et al. (2013) · Nature Immunology · doi:10.1038/ni.2570 · Cited by 552 · see citing works

Effectors and memories: Bcl-6 and Blimp-1 in T and B lymphocyte differentiation

Crotty, S., Johnston, R. J., & Schoenberger, S. P. (2010) · Nature Immunology · doi:10.1038/ni.1837 · Cited by 525 · see citing works

T-bet: a bridge between innate and adaptive immunity

Lazarevic, V., Glimcher, L. H., & Lord, G. M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3536 · Cited by 486 · see citing works

Metabolic checkpoints in activated T cells

Wang, R., & Green, D. R. (2012) · Nature Immunology · doi:10.1038/ni.2386 · Cited by 457 · see citing works

BATF–JUN is critical for IRF4-mediated transcription in T cells

Li, P., Spolski, R. J., Liao, W., Wang, L., Murphy, T. L., MURPHY, K. M. M., & Leonard, W. J. (2012) · Nature · doi:10.1038/nature11530 · Cited by 453 · see citing works

Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection

Tubo, N. J., Pagán, A. J., Taylor, J. J., Nelson, R. W., Linehan, J. L., Ertelt, J. M., Huseby, E. S., Way, S. S., & Jenkins, M. K. (2013) · Cell · doi:10.1016/j.cell.2013.04.007 · Cited by 444 · see citing works

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

Man, K., Miasari, M., Shi, W., Xin, A., Henstridge, D. C., Preston, S., Pellegrini, M., Belz, G. T., Smyth, G. K., Febbraio, M. A., et al. (2013) · Nature Immunology · doi:10.1038/ni.2710 · Cited by 407 · see citing works

Intrinsic and extrinsic control of peripheral T‐cell tolerance by costimulatory molecules of the CD28/ B7 family

Bour‐Jordan, H., Esensten, J. H., Martinez‐Llordella, M., Penaranda, C., Stumpf, M., & Bluestone, J. A. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01011.x · Cited by 391 · see citing works

Metabolism in T cell activation and differentiation

Pearce, E. L. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.01.018 · Cited by 314 · see citing works

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

Oestreich, K. J., Mohn, S. E., & Weinmann, A. S. (2012) · Nature Immunology · doi:10.1038/ni.2242 · Cited by 314 · see citing works

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function

Hogquist, K. A., & Jameson, S. C. (2014) · Nature Immunology · doi:10.1038/ni.2938 · Cited by 265 · see citing works

T-bet in disease

Lazarevic, V., & Glimcher, L. H. (2011) · Nature Immunology · doi:10.1038/ni.2059 · Cited by 248 · see citing works

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

Yao, S., Buzo, B. F. D., Pham, D., Jiang, L., Taparowsky, E. J., Kaplan, M. H., & Sun, J. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.007 · Cited by 236 · see citing works

Distinct TCR signaling pathways drive proliferation and cytokine production in T cells

Guy, C. S., Vignali, K. M., Temirov, J. P., Bettini, M. L., Overacre-Delgoffe, A. E., Smeltzer, M. P., Zhang, H., Huppa, J. B., Tsai, Y.-H., Lobry, C., et al. (2013) · Nature Immunology · doi:10.1038/ni.2538 · Cited by 229 · see citing works

The genetic network controlling plasma cell differentiation

Nutt, S. L., Taubenheim, N., Hasbold, J., Corcoran, L. M., & Hodgkin, P. D. (2011) · Seminars in Immunology · doi:10.1016/j.smim.2011.08.010 · Cited by 224 · see citing works

How T Cells Earn the Follicular Rite of Passage

Vinuesa, C. G., & Cyster, J. G. (2011) · Immunity · doi:10.1016/j.immuni.2011.11.001 · Cited by 211 · see citing works

Bcl-6 directly represses the gene program of the glycolysis pathway

Oestreich, K. J., Read, K. A., Gilbertson, S. E., Hough, K. P., McDonald, P. W., Krishnamoorthy, V., & Weinmann, A. S. (2014) · Nature Immunology · doi:10.1038/ni.2985 · Cited by 189 · see citing works

TCR signal quantity and quality in CD4+ T cell differentiation

Tubo, N. J., & Jenkins, M. K. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.09.008 · Cited by 146 · see citing works

Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors

Oestreich, K. J., & Weinmann, A. S. (2012) · Nature reviews. Immunology · doi:10.1038/nri3321 · Cited by 138 · see citing works

The Costimulatory Molecule CD27 Maintains Clonally Diverse CD8+ T Cell Responses of Low Antigen Affinity to Protect against Viral Variants

van Gisbergen, K. P. J. M., Klarenbeek, P. L., Kragten, N. A. M., Unger, P. A., Nieuwenhuis, M. B. B., Wensveen, F. M., ten Brinke, A., Tak, P. P., Eldering, E., Nolte, M. A., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.04.020 · Cited by 133 · see citing works

Graded Levels of IRF4 Regulate CD8+ T Cell Differentiation and Expansion, but Not Attrition, in Response to Acute Virus Infection

Nayar, R., Schutten, E., Bautista, B., Daniels, K. A., Prince, A., Enos, M., Brehm, M. A., Swain, S. L., Welsh, R. M., & Berg, L. J. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1303187 · Cited by 118 · see citing works

TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8 + T-cell differentiation

Nayar, R., Enos, M., Prince, A., Shin, H., Hemmers, S., Jiang, J., Klein, U., Thomas, C. J., & Berg, L. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1205742109 · Cited by 106 · see citing works

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysisPreprint

Liu, X., Haines, J. E., Mehanna, E. K., GENET, M. D., Ben‐Sahra, I., Asara, J. M., Manning, B. D., & Yuan, Z.-M. (2014) · Genes & Development · doi:10.1101/gad.245910.114 · Cited by 104 · see citing works

c-Myc-induced transcription factor AP4 is required for host protection mediated by CD8+ T cells

Chou, C., Pinto, A. K., Curtis, J. D., Persaud, S. P., Cella, M., Lin, C., Edelson, B. T., Allen, P. M., Colonna, M., Pearce, E. L., et al. (2014) · Nature Immunology · doi:10.1038/ni.2943 · Cited by 95 · see citing works

The BTB-ZF Family of Transcription Factors: Key Regulators of Lineage Commitment and Effector Function Development in the Immune System

Beaulieu, A. M., & Sant’Angelo, D. B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004006 · Cited by 86 · see citing works

Bcl-6 gets T cells off the sugar

Man, K., & Kallies, A. (2014) · Nature Immunology · doi:10.1038/ni.2993 · Cited by 4 · see citing works

Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention

Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Luo, Z., Tian, M., Yang, G., Tan, Q., Chen, Y., Li, G., Zhang, Q., Li, Y., Wan, P., & Wu, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01080-1 · Cited by 499 · see citing works

Aging of the immune system: Focus on inflammation and vaccination

Pinti, M., Appay, V., Campisi, J., Frasca, D., Fülöp, T., Sauce, D., Larbi, A., Weinberger, B., & Cossarizza, A. (2016) · European Journal of Immunology · doi:10.1002/eji.201546178 · Cited by 439 · see citing works

Engagement of a T cell receptor by major histocompatibility complex irrespective of peptide

Vessey, S. J. R., Barouch, D. H., McAdam, S. N., et al. (1997) · European Journal of Immunology · doi:10.1002/eji.1830270412 · Cited by 7 · see citing works

Current status and future challenges in T-cell receptor/peptide/MHC molecular dynamics simulations

Knapp, B., Demharter, S., Esmaielbeiki, R., & Deane, C. M. (2015) · Briefings in Bioinformatics · doi:10.1093/bib/bbv005 · Cited by 52 · see citing works

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Burrows, S. R., Chen, Z., Archbold, J. K., Tynan, F. E., Beddoe, T., Kjer‐Nielsen, L., Miles, J. J., Khanna, R., Moss, D. J., Liu, Y. C., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004926107 · Cited by 116 · see citing works

Molecular modeling of a T-cell receptor bound to a major histocompatibility complex molecule: Implications for T-cell recognition

Almagro, J. C., Vargas‐Madrazo, E., Lara‐Ochoa, F., & Horjales, E. (1995) · Protein Science · doi:10.1002/pro.5560040906 · Cited by 12 · see citing works

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

Adams, J., Narayanan, S., Liu, B., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.013 · Cited by 273 · see citing works