The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
MAINTENANCE OF SERUM ANTIBODY LEVELS
Abstract
▪ Abstract In vertebrates, serum antibodies are an essential component of innate and adaptive immunity and immunological memory. They also can contribute significantly to immunopathology. Their composition is the result of tightly regulated differentiation of B lymphocytes into antibody-secreting plasma blasts and plasma cells. The survival of antibody-secreting cells determines their contribution to the immune response in which they were generated and to long-lasting immunity, as provided by stable serum antibody levels. Short-lived plasma blasts and/or plasma cells secrete antibodies for a reactive immune response. Short-lived plasma blasts can become long-lived plasma cells, probably by competition with preexisting plasma cells for occupation of a limited number of survival niches in the body, in a process not yet fully understood. Limitation of the number of long-lived plasma cells allows the immune system to maintain a stable humoral immunological memory over long periods, to react to new pathogenic challenges, and to adapt the humoral memory in response to these antigens.
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Citations
Cites
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Self-citationAn IgG‐transporting Fc receptor expressed in the syncytiotrophoblast of human placenta
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Cited by
Duration of Humoral Immunity to Common Viral and Vaccine Antigens
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T Follicular Helper (TFH) Cells in Normal and Dysregulated Immune Responses
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Self-citationAntibody-independent functions of B cells: a focus on cytokines
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Comprehensive serological profiling of human populations using a synthetic human virome
Xu, G. J., Kula, T., Xu, Q., Li, M. Z., Vernon, S. D., Ndung’u, T., Ruxrungtham, K., Sanchez, J., Brander, C., Chung, R. T., et al. (2015) · Science · doi:10.1126/science.aaa0698 · Cited by 477
Metadata
- Authors
- Manz, R. A., Hauser, A. E., Hiepe, F., & Radbruch, A.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2005-04-01
- Volume
- 23
- Issue
- 1
- Pages
- 367-386
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2136060817
- Cited by
- 539
- References
- 7
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Manz, R. A., Hauser, A. E., Hiepe, F., & Radbruch, A. (2005). MAINTENANCE OF SERUM ANTIBODY LEVELS. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.23.021704.115723
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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