An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

C-reactive protein: a critical update

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C-reactive protein: a critical update

Pepys, M. B., & Hirschfield, G. M. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318921 · Cited by 3,436 · see citing works

C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

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Serum amyloid A, the major vertebrate acute‐phase reactant

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Immunoregulatory functions of surfactant proteins

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Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility.

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Genetically elevated C-reactive protein and ischemic vascular disease

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Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense

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Complement evasion by human pathogens

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Evolution of the lectin–complement pathway and its role in innate immunity

Fujita, T. (2002) · Nature reviews. Immunology · doi:10.1038/nri800 · Cited by 697 · see citing works

C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response

Gershov, D., Kim, S., Brot, N., & Elkon, K. B. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1353 · Cited by 695 · see citing works

Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

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By Binding SIRPα or Calreticulin/CD91, Lung Collectins Act as Dual Function Surveillance Molecules to Suppress or Enhance Inflammation

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The lectin‐complement pathway – its role in innate immunity and evolution

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Novel and Conventional Biomarkers for Prediction of Incident Cardiovascular Events in the Community

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The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps

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Anti-Inflammatory Actions of Intravenous Immunoglobulin

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Surfactant proteins SP-A and SP-D: structure, function and receptors

Kishore, U., Greenhough, T. J., Waters, P., Shrive, A. K., Ghai, R., Kamran, M. F., Bernal, A. L., Reid, K. B. M., Madan, T., & Chakraborty, T. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2005.08.004 · Cited by 523 · see citing works

Role of Surfactant Proteins A, D, and C1q in the Clearance of Apoptotic Cells In Vivo and In Vitro: Calreticulin and CD91 as a Common Collectin Receptor Complex

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C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids

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Structure of pentameric human serum amyloid P component

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PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization

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Pentraxins in Innate Immunity: From C-Reactive Protein to the Long Pentraxin PTX3

Mantovani, A., Garlanda, C., Doni, A., & Bottazzi, B. (2007) · Journal of Clinical Immunology · doi:10.1007/s10875-007-9126-7 · Cited by 440 · see citing works

C1q and tumor necrosis factor superfamily: modularity and versatility

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A Seven-transmembrane, G Protein–coupled Receptor, FPRL1, Mediates the Chemotactic Activity of Serum Amyloid A for Human Phagocytic Cells

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Mannose-binding lectin and its genetic variants

Garred, P., Larsen, F., Seyfarth, J., Fujita, R., & MADSEN, H. O. (2006) · Genes and Immunity · doi:10.1038/sj.gene.6364283 · Cited by 418 · see citing works

Interleukin-1-inducible genes in endothelial cells. Cloning of a new gene related to C-reactive protein and serum amyloid P component.

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The Major Receptor for C-Reactive Protein on Leukocytes Is Fcγ Receptor II

Bharadwaj, D., Stein, M., Volzer, M. A., Mold, C., & Clos, T. W. D. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.4.585 · Cited by 391 · see citing works

Localization of Lung Surfactant Protein D on Mucosal Surfaces in Human Tissues

Madsen, J., Kliem, A., Tornøe, I., Skjødt, K., Koch, C., & Holmskov, U. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.11.5866 · Cited by 386 · see citing works

Multimer Formation and Ligand Recognition by the Long Pentraxin PTX3

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C‐reactive protein and coronary heart disease: a critical review

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Complement activation and inhibition: a delicate balance

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Three dimensional structure of human C-reactive protein

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Biochemical and functional characterization of the interaction between pentraxin 3 and C1q

Nauta, A. J., Bottazzi, B., Mantovani, A., Salvatori, G., Kishore, U., Schwaeble, W., Gingras, A. R., Tzima, S., Vivanco, F., Egido, J., et al. (2003) · European Journal of Immunology · doi:10.1002/immu.200310022 · Cited by 348 · see citing works

Serum amyloid A induces IL-8 secretion through a G protein–coupled receptor, FPRL1/LXA4R

He, R., Sang, H., & Ye, R. D. (2003) · Blood · doi:10.1182/blood-2002-05-1431 · Cited by 329 · see citing works

Cardioprotective Function of the Long Pentraxin PTX3 in Acute Myocardial Infarction

Salio, M., Chimenti, S., Angelis, N. D., Molla, F., Maina, V., Nebuloni, M., Pasqualini, F., Latini, R., Garlanda, C., & Mantovani, A. (2008) · Circulation · doi:10.1161/circulationaha.107.749234 · Cited by 326 · see citing works

Structural recognition and functional activation of FcγR by innate pentraxins

Lu, J., Marnell, L. L., Marjon, K. D., Mold, C., Clos, T. W. D., & Sun, P. D. (2008) · Nature · doi:10.1038/nature07468 · Cited by 299 · see citing works

THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD

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Properdin Can Initiate Complement Activation by Binding Specific Target Surfaces and Providing a Platform for De Novo Convertase Assembly

Spitzer, D., Mitchell, L. M., Atkinson, J. P., & Hourcade, D. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2600 · Cited by 281 · see citing works

Complexity and Complementarity of Outer Membrane Protein A Recognition by Cellular and Humoral Innate Immunity Receptors

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Amyloid deposition is delayed in mice with targeted deletion of the serum amyloid P component gene

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Complement Receptor 1/Cd35 Is a Receptor for Mannan-Binding Lectin

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TSG-14, a tumor necrosis factor- and IL-1-inducible protein, is a novel member of the pentaxin family of acute phase proteins

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Human M-Ficolin Is a Secretory Protein That Activates the Lectin Complement Pathway

Liu, Y., Endo, Y., Iwaki, D., Nakata, M., Matsushita, M., Wada, I., Inoue, K., Munakata, M., & Fujita, T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.5.3150 · Cited by 245 · see citing works

Serum amyloid A is an innate immune opsonin for Gram-negative bacteria

Shah, C., Hari-Dass, R., & Raynes, J. G. (2006) · Blood · doi:10.1182/blood-2005-11-011932 · Cited by 244 · see citing works

The Role of Properdin in the Assembly of the Alternative Pathway C3 Convertases of Complement

Hourcade, D. E. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m508928200 · Cited by 233 · see citing works

Recognition and clearance of apoptotic cells: a role for complement and pentraxins

Nauta, A. J., Daha, M. R., van Kooten, C., & Roos, A. (2003) · Trends in Immunology · doi:10.1016/s1471-4906(03)00030-9 · Cited by 231 · see citing works

Justification for the Use of Statins in Primary Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER)—Can C-Reactive Protein Be Used to Target Statin Therapy in Primary Prevention?

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Surfactant Proteins A and D Bind CD14 by Different Mechanisms

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Surfactant Proteins A and D Suppress Alveolar Macrophage Phagocytosis via Interaction with SIRPα

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Regulation of Complement Activation by C-Reactive Protein: Targeting the Complement Inhibitory Activity of Factor H by an Interaction with Short Consensus Repeat Domains 7 and 8–11

Jarva, H., Jokiranta, T. S., Hellwage, J., Zipfel, P. F., & Meri, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.7.3957 · Cited by 197 · see citing works

Structural insights into the innate immune recognition specificities of L‐ and H‐ficolins

Garlatti, V., Belloy, N., Martin, L., Lacroix, M., Matsushita, M., Endo, Y., Fujita, T., Fontecilla-Camps, J. C., Arlaud, G. J., Thielens, N. M., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601500 · Cited by 197 · see citing works

Antiviral Activity of the Long Chain Pentraxin PTX3 against Influenza Viruses

Reading, P. C., Bozza, S., Gilbertson, B. P., Tate, M. D., Moretti, S., Job, E. R., Crouch, E. C., Brööks, A. G., Brown, L. E., Bottazzi, B., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3391 · Cited by 190 · see citing works

TNFα-Induced Long Pentraxin PTX3 Expression in Human Lung Epithelial Cells via JNK

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Topology and Structure of the C1q-Binding Site on C-Reactive Protein

Agrawal, A. C., Shrive, A. K., Greenhough, T. J., & Volanakis, J. E. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.6.3998 · Cited by 187 · see citing works

Purification of a Cell-surface Receptor for Surfactant Protein A

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The long pentraxin PTX3 as a prototypic humoral pattern recognition receptor: interplay with cellular innate immunity

Bottazzi, B., Garlanda, C., Cotena, A., Moalli, F., Jaillon, S., Deban, L., & Mantovani, A. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00719.x · Cited by 186 · see citing works

Mannose‐Binding Lectin Regulates the Inflammatory Response of Human Professional Phagocytes toNeisseria meningitidisSerogroup B

Jack, D. L., Read, R. C., Tenner, A. J., Frosch, M., TURNER, M. W., & Klein, N. J. (2001) · The Journal of Infectious Diseases · doi:10.1086/323803 · Cited by 185 · see citing works

Binding of the Long Pentraxin PTX3 to Factor H: Interacting Domains and Function in the Regulation of Complement Activation

Deban, L., Jarva, H., Lehtinen, M. J., Bottazzi, B., Bastone, A., Doni, A., Jokiranta, T. S., Mantovani, A., & Meri, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.12.8433 · Cited by 185 · see citing works

DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans

Olesen, R., Wejse, C. M., Velez, D. R., Bisseyé, C., Sodemann, M., Aaby, P., Rabna, P., Worwui, A. K., Chapman, H. L., Diatta, M., et al. (2007) · Genes and Immunity · doi:10.1038/sj.gene.6364410 · Cited by 184 · see citing works

Serum Amyloid A Binding to CLA-1 (CD36 and LIMPII Analogous-1) Mediates Serum Amyloid A Protein-induced Activation of ERK1/2 and p38 Mitogen-activated Protein Kinases

Baranova, I. N., Vishnyakova, T. G., Bocharov, A. V., Kurlander, R. J., Chen, Z., Kimelman, M., Remaley, A. T., Csákó, G., Fairwell, T., Eggerman, T. L., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405009200 · Cited by 184 · see citing works

Synergy between Ficolin-2 and Pentraxin 3 Boosts Innate Immune Recognition and Complement Deposition

Ma, Y. J., Doni, A., Hummelshøj, T., Honoré, C., Bastone, A., Mantovani, A., Thielens, N. M., & Garred, P. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009225 · Cited by 182 · see citing works

Murine serum amyloid A3 is a high density apolipoprotein and is secreted by macrophages.

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Production of the soluble pattern recognition receptor PTX3 by myeloid, but not plasmacytoid, dendritic cells

Doni, A., Peri, G., Chieppa, M., Allavena, P., Pasqualini, F., Vago, L., Romani, L. R., Garlanda, C., & Mantovani, A. (2003) · European Journal of Immunology · doi:10.1002/eji.200324390 · Cited by 174 · see citing works

Immunodeficiency Associated with FCN3 Mutation and Ficolin-3 Deficiency

Munthe‐Fog, L., Hummelshøj, T., Honoré, C., MADSEN, H. O., Permin, H., & Garred, P. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0900381 · Cited by 171 · see citing works

The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens

He, Y.-W., Li, H., Zhang, J., Hsu, C.-L., Lin, E., Zhang, N., Guo, J., Forbush, K. A., & Bevan, M. J. (2004) · Nature Immunology · doi:10.1038/ni1021 · Cited by 171 · see citing works

PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages

Diniz, S. N., Nomizo, R., Cisalpino, P. S., Teixeira, M. M., Brown, G. D., Mantovani, A., Gordon, S., Reis, L. F. L., & Dias, A. A. M. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0803371 · Cited by 171 · see citing works

Serum amyloid A induces G-CSF expression and neutrophilia via Toll-like receptor 2

He, R. L., Zhou, J. H., Hanson, C. Z., Jia, C., Cheng, N., & Ye, R. D. (2008) · Blood · doi:10.1182/blood-2008-03-139923 · Cited by 169 · see citing works

Human Mannose-binding Lectin and l-Ficolin Function as Specific Pattern Recognition Proteins in the Lectin Activation Pathway of Complement

Ma, Y. G., Cho, M. Y., Zhao, M., Park, J. W., Matsushita, M., Fujita, T., & Lee, B. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400701200 · Cited by 166 · see citing works

Maturation of dendritic cells abrogates C1q production in vivo and in vitro

Castellano, G., Woltman, A. M., Nauta, A. J., Roos, A., Trouw, L. A., Seelen, M. A., Schena, F. P., Daha, M. R., & van Kooten, C. (2004) · Blood · doi:10.1182/blood-2003-09-3046 · Cited by 164 · see citing works

Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome

Ip, W., Takahashi, K., Moore, K. J., Stuart, L. M., & Ezekowitz, R. A. B. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071164 · Cited by 163 · see citing works

Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen.

Noursadeghi, M., Bickerstaff, M., Gallimore, J., Herbert, J., Cohen, J., & Pepys, M. (2000) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.97.26.14584 · Cited by 162 · see citing works

MBL2, FCN1, FCN2 and FCN3—The genes behind the initiation of the lectin pathway of complement

Garred, P., Honoré, C., Ma, Y. J., Munthe‐Fog, L., & Hummelshøj, T. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.05.005 · Cited by 161 · see citing works

M‐ficolin is expressed on monocytes and is a lectin binding to N‐acetyl‐ d ‐glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli

Teh, C., Le, Y., Lee, S. H., & Lu, J. (2000) · Immunology · doi:10.1046/j.1365-2567.2000.00099.x · Cited by 156 · see citing works

Serum Amyloid A Protein Binds to Outer Membrane Protein A of Gram-negative Bacteria

Hari-Dass, R., Shah, C., Meyer, D. J., & Raynes, J. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500490200 · Cited by 152 · see citing works

PTX3 Interacts with Inter-α-trypsin Inhibitor

Scarchilli, L., Camaioni, A., Bottazzi, B., Negri, V., Doni, A., Deban, L., Bastone, A., Salvatori, G., Mantovani, A., Siracusa, G., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703738200 · Cited by 149 · see citing works

Serum Amyloid P Component and C-Reactive Protein Mediate Phagocytosis Through Murine FcγRs

Mold, C., Gresham, H. D., & Clos, T. W. D. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.2.1200 · Cited by 148 · see citing works

Interaction of C1q with IgG1, C-reactive Protein and Pentraxin 3: Mutational Studies Using Recombinant Globular Head Modules of Human C1q A, B, and C Chains

Roumenina, L. T., Ruseva, M. M., Zlatarova, A. S., Ghai, R., Kolev, M. V., Olova, N. N., Gadjeva, M. G., Agrawal, A. C., Bottazzi, B., Mantovani, A., et al. (2006) · Biochemistry · doi:10.1021/bi052646f · Cited by 148 · see citing works

Human Pulmonary Surfactant Protein D Binds the Extracellular Domains of Toll-like Receptors 2 and 4 through the Carbohydrate Recognition Domain by a Mechanism Different from Its Binding to Phosphatidylinositol and Lipopolysaccharide

Ohya, M., Nishitani, C., Sano, H. I., Yamada, C., Mitsuzawa, H., Shimizu, T., Saito, T., Smith, K., Crouch, E. C., & Kuroki, Y. (2006) · Biochemistry · doi:10.1021/bi060176z · Cited by 148 · see citing works

Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells In Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis

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Long Pentraxin 3, a Key Component of Innate Immunity, Is Modulated by High-Density Lipoproteins in Endothelial Cells

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Pulmonary Surfactant Protein A Regulates TLR Expression and Activity in Human Macrophages

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Structural Characterization of PTX3 Disulfide Bond Network and Its Multimeric Status in Cumulus Matrix Organization

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Anti- Aspergillus fumigatus Efficacy of Pentraxin 3 Alone and in Combination with Antifungals

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Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation

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Structure and Function of the Long Pentraxin PTX3 Glycosidic Moiety: Fine-Tuning of the Interaction with C1q and Complement Activation

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Pulmonary Surfactant Protein A Augments the Phagocytosis of Streptococcus pneumoniae by Alveolar Macrophages through a Casein Kinase 2-dependent Increase of Cell Surface Localization of Scavenger Receptor A

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Identification of an Antiangiogenic FGF2-binding Site in the N Terminus of the Soluble Pattern Recognition Receptor PTX3

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Local Inflammation Induces Complement Crosstalk Which Amplifies the Antimicrobial Response

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Cell-specific Regulation of PTX3 by Glucocorticoid Hormones in Hematopoietic and Nonhematopoietic Cells

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Human Serum Amyloid A Protein Inhibits Hepatitis C Virus Entry into Cells

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A Novel Mechanism of Complement Inhibition Unmasked by a Tick Salivary Protein That Binds to Properdin

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The α2β1 integrin: A novel collectin/C1q receptor

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Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?

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Serum amyloid A‐induced IL‐6 production by rheumatoid synoviocytes

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Overexpression of a member of the pentraxin family (PTX3) in human soft tissue liposarcoma

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Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G

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Serum Amyloid P Component Binds to Influenza A Virus Haemagglutinin and Inhibits the Virus Infection In Vitro

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Human C-Reactive Protein Protects Mice from Streptococcus pneumoniae Infection without Binding to Pneumococcal C-Polysaccharide

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Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth

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Genetic Variation in Pentraxin (PTX) 3 Gene Associates with PTX3 Production and Fertility in Women1

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Expression sites of the collectin SP-D suggest its importance in first line host defence: Power of combining in situ hybridisation, RT-PCR and immunohistochemistry

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Pattern Recognition Molecule Mindin Promotes Intranasal Clearance of Influenza Viruses

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Surfactant protein‐A mRNA expression by human fetal membranes is increased in histological chorioamnionitis but not in spontaneous labour at term

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Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

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Neutrophils in the activation and regulation of innate and adaptive immunity

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Macrophage plasticity and polarization in tissue repair and remodelling

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Adverse childhood experiences, allostasis, allostatic load and age-related disease

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Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns

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Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

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Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

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PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

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Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity

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The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis

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Pattern recognition receptors: function, regulation and therapeutic potential

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Humoral Innate Immunity and Acute-Phase Proteins

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Neutrophils in innate and adaptive immunity

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Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype

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Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease

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Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

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Immunomodulatory Effects of Dietary Polyphenols

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Inflammation in sleep apnea: An update

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PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer

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Urinary phthalate metabolites in relation to biomarkers of inflammation and oxidative stress: NHANES 1999–2006

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The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling

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Endogenous and exogenous pentraxin-3 limits postischemic acute and chronic kidney injury

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Pathogen Recognition by the Long Pentraxin PTX3

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Role of epigenetics in transformation of inflammation into colorectal cancer

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