The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Clinical Pharmacology of Caffeine
Abstract
Caffeine is the most widely consumed stimulant drug in the world. This chapter reviews the human pharmacology of caffeine; the evidence for its role in causing human disease, including addiction; and its potential usefulness as a therapeutic agent.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Effects of Caffeine on Plasma Renin Activity, Catecholamines and Blood Pressure
Robertson, D., Frölich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., & Oates, J. A. (1978) · New England Journal of Medicine · doi:10.1056/nejm197801262980403 · Cited by 757
Tolerance to the humoral and hemodynamic effects of caffeine in man.
Robertson, D., Wade, D., Workman, R., Woosley, R. L., & Oates, J. A. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110124 · Cited by 501
The effects of low doses of caffeine on human performance and mood
Lieberman, H. R., Wurtman, R. J., Emde, G. G., Roberts, C., & Coviella, I. L. G. (1987) · Psychopharmacology · doi:10.1007/bf00210835 · Cited by 413
Caffeine physical dependence: a review of human and laboratory animal studies
Griffiths, R. R., & Woodson, P. P. (1988) · Psychopharmacology · doi:10.1007/bf00212836 · Cited by 276
Coffee consumption and the incidence of coronary heart disease.
LaCroix, A. Z., Mead, L. A., Liang, K.-Y., Thomas, C. B., & Pearson, T. A. (1986) · New England Journal of Medicine · doi:10.1056/nejm198610163151601 · Cited by 183
Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men
Pincomb, G. A., Lovallo, W. R., Passey, R. B., Whitsett, T. L., Silverstein, S. M., & Wilson, M. F. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)90578-8 · Cited by 137
Freestone, S., & Ramsay, L. E. (1982) · The American Journal of Medicine · doi:10.1016/0002-9343(82)90725-2 · Cited by 117
Cited by
Effects of caffeine on human health
Nawrot, P., Jordan, S., Eastwood, J., Rotstein, J., Hugenholtz, A., & Feeley, M. (2003) · Food Additives and Contaminants · doi:10.1080/0265203021000007840 · Cited by 1,199
Haller, C. A., & Benowitz, N. L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200012213432502 · Cited by 956
Self-citationCaffeine and Exercise: Metabolism, Endurance and Performance
Graham, T. E. (2001) · Sports Medicine · doi:10.2165/00007256-200131110-00002 · Cited by 819
Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug?
Cappelletti, S., Daria, P., Sani, G., & Aromatario, M. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13666141210215655 · Cited by 631
“Caffeine’s half-life in humans ranges from a minimum of 2 to a maximum of 12 hours [21, 22], mainly due to the interindividual variability in absorption and metabolism.”
BackgroundAre we dependent upon coffee and caffeine? A review on human and animal data
Nehlig, A. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(98)00050-5 · Cited by 453
Individual variability in human blood metabolites identifies age-related differences
Chaleckis, R., Murakami, I., Takada, J., Kondoh, H., & Yanagida, M. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1603023113 · Cited by 373
Coffee components and cardiovascular risk: beneficial and detrimental effects
Godos, J., Pluchinotta, F. R., Marventano, S., Buscemi, S., Li Volti, G., Galvano, F., & Grosso, G. (2014) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.940287 · Cited by 210
Caffeine effects on resting-state arousal
Barry, R. J., Rushby, J. A., Wallace, M. J., Clarke, A. R., Johnstone, S. J., & Zlojutro, I. (2005) · Clinical Neurophysiology · doi:10.1016/j.clinph.2005.08.008 · Cited by 190
Pharmacokinetic-pharmacodynamic modeling of caffeine: tolerance to pressor effects.
Shi, J., Benowitz, N. L., Denaro, C. P., & Sheiner, L. B. (1993) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1993.3 · Cited by 99
Self-citationFatal Caffeine Intoxication: A Series of Eight Cases from 1999 to 2009
Banerjee, P., Ali, Z., Levine, B., & Fowler, D. R. (2014) · Journal of Forensic Sciences · doi:10.1111/1556-4029.12387 · Cited by 93
Doepker, C., Lieberman, H. R., Smith, A. P., Peck, J. D., El-Sohemy, A., & Welsh, B. T. (2016) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-041715-033243 · Cited by 87
The effects of caffeine on ambulatory blood pressure, heart rate, and mood in coffee drinkers
Green, P. J., & Suls, J. (1996) · Journal of Behavioral Medicine · doi:10.1007/bf01857602 · Cited by 84
The Role of Genetics in Moderating the Inter-Individual Differences in the Ergogenicity of Caffeine
Southward, K., Rutherfurd-Markwick, K., Badenhorst, C., & Ali, A. (2018) · Nutrients · doi:10.3390/nu10101352 · Cited by 81
A pilot study of plasma caffeine concentrations in a US sample of smoker and nonsmoker volunteers
de Leon, J., Diaz, F. J., Rogers, T., Browne, D., Dinsmore, L., Ghosheh, O. H., Dwoskin, L. P., & Crooks, P. A. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00348-2 · Cited by 77
Shen, J. G., Brooks, M. B., Cincotta, J., & Manjourides, J. D. (2019) · Journal of Science and Medicine in Sport · doi:10.1016/j.jsams.2018.07.022 · Cited by 75
Effect of Green Tea Phytochemicals on Mood and Cognition
Dietz, C., & Dekker, M. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666170105151800 · Cited by 70
Assessing a hyperarousal hypothesis of insomnia in adults with autism spectrum disorder
Baker, E. K., Richdale, A. L., Hazi, A., & Prendergast, L. A. (2019) · Autism Research · doi:10.1002/aur.2094 · Cited by 42
Kahathuduwa, C. N., Dhanasekara, C. S., Chin, S.-H., Davis, T., Weerasinghe, V. S., Dassanayake, T. L., & Binks, M. (2018) · Nutrition Research · doi:10.1016/j.nutres.2017.11.002 · Cited by 46
Cola-induced hypokalaemia: pathophysiological mechanisms and clinical implications
Tsimihodimos, V., Kakaidi, V., & Elisaf, M. (2009) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02051.x · Cited by 40
Portuguese Football Federation consensus statement 2020: nutrition and performance in football
Abreu, R., Figueiredo, P., Beckert, P., Marques, J. P., Amorim, S., Caetano, C., Carvalho, P., Sá, C., Cotovio, R., Cruz, J., et al. (2021) · BMJ Open Sport & Exercise Medicine · doi:10.1136/bmjsem-2021-001082 · Cited by 38
Influence of age on the thermic response to caffeine in women
Arciero, P. J., Bougopoulos, C. L., Nindl, B. C., & Benowitz, N. L. (2000) · Metabolism · doi:10.1016/s0026-0495(00)90888-6 · Cited by 34
Self-citationDoes caffeine confound relationships among adrenergic tone, blood pressure and sleep apnoea?
Bardwell, Ziegler, Ancoli‐Israel, Berry, Nelesen, Durning, & Dimsdale (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00209.x · Cited by 29
Chronic Caffeine Exposure Attenuates Blast-Induced Memory Deficit in Mice
Ning, Y.-L., Yang, N., Chen, X., Zhao, Z.-A., Zhang, X.-Z., Chen, X.-Y., Li, P., Zhao, Y., & Zhou, Y.-G. (2015) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2015.10.003 · Cited by 24
Tajima, Y. (2010) · Clinical Medicine Insights: Case Reports · doi:10.4137/ccrep.s4329 · Cited by 22
Porto, A. A., Benjamim, C. J. R., Gonzaga, L. A., Luciano de Almeida, M., Bueno Júnior, C. R., Garner, D. M., & Valenti, V. E. (2022) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.01.015 · Cited by 20
Hunt, M. G., Momjian, A. J., & Wong, K. K. (2011) · Psychological Assessment · doi:10.1037/a0021401 · Cited by 18
Metadata
- Authors
- Benowitz, N. L.
- Venue
- Annual Review of Medicine
- Publisher
- Annual Reviews
- Published
- 1990-02
- Volume
- 41
- Issue
- 1
- Pages
- 277-288
- ISSN
- 0066-4219 (ISSN-L)
- 1545-326X
- OpenAlex
- W2174255320
- Cited by
- 420
- References
- 7
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.