Genetics of Longevity and Aging

Aging: a theory based on free radical and radiation chemistry

Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567

Pleiotropy, natural selection, and the evolution of senescence.

Williams, G. C. (1957) · Evolution · doi:10.1111/j.1558-5646.1957.tb02911.x · Cited by 4,279

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510

A C. elegans mutant that lives twice as long as wild type

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K. F., Greer, P. L., Lin, Y., Tran, H., Ross, S. E., Mostoslavsky, R., Cohen, H. Y., et al. (2004) · Science · doi:10.1126/science.1094637 · Cited by 3,239

Broken Limits to Life Expectancy

Oeppen, J., & Vaupel, J. W. (2002) · Science · doi:10.1126/science.1069675 · Cited by 2,819

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109

Negative Control of p53 by Sir2α Promotes Cell Survival under Stress

Luo, J., Nikolaev, A. Y., Imai, S.-I., Chen, D., Su, F., Shiloh, A., Guarente, L., & Gu, W. (2001) · Cell · doi:10.1016/s0092-8674(01)00524-4 · Cited by 2,081

Evolution of ageing

Kirkwood, T. B. L. (1977) · Nature · doi:10.1038/270301a0 · Cited by 2,007

AN UNSOLVED PROBLEM OF BIOLOGY

(1953) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1953.tb84985.x · Cited by 1,806

A microsatellite polymorphism in IGF1 gene promoter and longevity in a Han Chinese population

Xie, L., Gong, Y., Lian, S.-G., Yang, J., Gao, S., Xu, L., & Zhang, Y. (2010) · BMC Research Notes · doi:10.1186/1756-0500-3-55 · Cited by 4

Longevics: Genetic lessons for the ages

Ross, O. A. (2006) · Irish Journal of Medical Science (1971 -) · doi:10.1007/bf03169012 · Cited by 4

Molecular Mechanism of Tumor Suppression Activity of C/EBPβ mRNA 3′UTR: Simultaneous Deletion of 3 Short Sequences in The 3'UTR Reduces Its Tumor Suppression Activity*

Wang, H., Wang, Y., Sun, D.-Q., & Liu, D.-G. (2010) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2009.00144 · Cited by 3

Aging as a consequence of intracellular water volume and density

Bonatto, D., Feltes, B. C., & Poloni, J. D. F. (2011) · Medical Hypotheses · doi:10.1016/j.mehy.2011.08.025 · Cited by 3

Screening of longevity-associated genes based on a comparison between dead and surviving populations

An, W., Zhang, L., Benlan, G., Sashuang, R., & Liu, H. (2013) · Gene · doi:10.1016/j.gene.2013.08.070 · Cited by 3

SNP'ing for longevity

Vijg, J. (2009) · Aging · doi:10.18632/aging.100048 · Cited by 3

The caloric restriction fallacy, rodent diet aids and the tumor suppression theory of agingPreprint

Wolf, A. M. (2021) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/a2689 · Cited by 2

Biogenetic Mechanisms Predisposing to Complex Phenotypes in Parents May Function Differently in Their Children

Kulminski, A. M., Arbeev, K. G., Christensen, K., Stallard, E., Miljkovic, I., Barmada, M. M., & Yashin, A. I. (2012) · The Journals of Gerontology Series A · doi:10.1093/gerona/gls243 · Cited by 2

Not Seeing Double: Discordance in Disease, Function, and Their Longitudinal Associations in Monozygotic Twins

Teas, E., Robertson, O. C., Marceau, K., & Friedman, E. M. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000972 · Cited by 2

Methuselah proteins in Drosophila: Structural and evolutionary insights from mathematical genomics

Hassan, S. S., Nawn, D., Ghosh, A., Sil, M., Goswami, A., Basu, P., Lundstrom, K. H., & Uversky, V. N. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152240 · Cited by 2

Pushing the Complexity Barrier: Diminishing Returns in the SciencesPreprint

Gros, C. (2012) · SSRN Electronic Journal · doi:10.2139/ssrn.2164070 · Cited by 2

Mouse Models of Accelerated Aging

Vijg, J., & Hasty, P. (2006) · Elsevier eBooks · doi:10.1016/b978-012369391-4/50050-3 · Cited by 2

Recruitment, Mortality and Longevity

Jönsson, B., & Jönsson, N. (2011) · Springer eBooks · doi:10.1007/978-94-007-1189-1_8 · Cited by 1

Unexpected effects of tumor-suppressing genes on fruit fly development

Weisman, N. Y. (2014) · Biology Bulletin Reviews · doi:10.1134/s207908641401006x · Cited by 1

Genetic variants determining survival and fertility in an adverse African environment: a population-based large-scale candidate gene association study

Koopman, J. J. E., Pijpe, J., Böhringer, S., van Bodegom, D., Eriksson, U. K., Sanchez-Faddeev, H., Ziem, J. B., Zwaan, B. J., Slagboom, P. E., de Knijff, P., et al. (2016) · Aging · doi:10.18632/aging.100986 · Cited by 1

The Complex Role of Genes in Diseases and Traits in Late Life: An Example of the Apolipoprotein E Polymorphism

Kulminski, A. M., Yashin, A. I., Culminskaya, I. V., Land, K. C., & Ukraintseva, S. V. (2016) · The Springer series on demographic methods and population analysis · doi:10.1007/978-94-017-7587-8_9 · Cited by 1

Continuing the Search for Determinants of Healthy Life Span and Longevity

Kulminski, A. M., Yashin, A. I., Arbeev, K. G., Ukraintseva, S. V., Akushevich, I. V., Land, K. C., & Stallard, E. (2016) · The Springer series on demographic methods and population analysis · doi:10.1007/978-94-017-7587-8_20 · Cited by 1

Blood RNA expression profiles undergo major changes during the seventh decade

Gheorghe, M., Schurmann, C., Peters, M. J., Uitterlinden, A. G., Albert Hofman, D., Biffar, R., Homuth, G., Völker, U., van Meurs, J. B. J., & Raz, V. (2016) · Oncotarget · doi:10.18632/oncotarget.12098 · Cited by 1

Investigating the Causes of Cellular Aging and Uncovering the Novel Vision of Anti-aging Therapeutics

Ashwin Prabahar, A. (2023) · Journal of Clinical and Medical Research · doi:10.37191/mapsci-2582-4333-5(2)-130

Post-Genomic View of Aging: Definitions, Theories and Observations

Marı́n-Garcı́a, J., Goldenthal, M. J., & Moe, G. W. P. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74072-0_1 · Cited by 1

Genetic Determinants of Human Life‐Span

Jylhävä, J., & Hurme, M. (2012) · Wiley eBooks · doi:10.1002/9780470015902.a0021463 · Cited by 1

A new challenge for diabetologists and geriatricians!

Tréton, J. (2005) · Diabetes & Metabolism · doi:10.1016/s1262-3636(05)73646-6 · Cited by 1

GENE EXPRESSION STUDIES IN CANDIDA ALBICANS

Uppuluri, P. (2006) · ThinkTech (Texas Tech University) · Cited by 1

DNA and Gene Expression

Vijg, J. (2007) · Elsevier eBooks · doi:10.1016/b0-12-370870-2/00055-x · Cited by 1

Longevity-associated SMAD3 non-coding centenarian variant impairs a cell-type specific enhancer to reduce inflammationPreprint

Yang, J., Tare, A., Zhang, L. J., Kim, S., Ryu, S., Guo, Q., Zhu, Y., Wang, X., Wang, X., Hudgins, A. D., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.17.540984 · Cited by 2

GH & IGF1: Aspects of Global and Local Release and Actions

Robinson, I. C. A. F. (2009) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-642-04302-4_1

CAVEOLIN-1 MEDIATED P53 ACTIVATION IN STRESS INDUCED PREMATURE SENESCENCE AND ITS ANTAGONISTIC PLEIOTROPIC IMPLICATIONS IN CANCER

Bartholomew, J. N. (2009) · D-Scholarship@Pitt (University of Pittsburgh)

An analysis of Apc5p/Fob1p interactions in yeast : implications for extended lifespan

Chen, J. C. (2006) · University Library - University of Saskatchewan (University of Saskatchewan)

The Janus Face of Insulin in Brain

Duarte, A. I., Candeias, E., Correia, S. C., Santos, R. X., Carvalho, C., Cardoso, S., Plácido, A. I., Santos, M. S., Oliveira, C. R., & Moreira, P. I. (2013) · Wiley eBooks · doi:10.1002/9781118395318.ch5

A study into genes encoding longevity in humans

Kuningas, M. (2007) · Leiden Repository (Leiden University)

GENETIC REGULATION OF HEMATOPOIETIC STEM CELL AGING

Oakley, E. J. (2008) · UKnowledge (University of Kentucky)

Projeto Bambuí: Um Estudo Epidemiológico de Base Populacional do Polimorfismo da Apolipoproteína E e sua Associação com Variáveis Demográficas, Biológicas e com a Hipertensão Arterial Prevalente em Idosos.

Fuzikawa, A. K. (2007) · Americanae (AECID Library)

Division of Biological and Medical Research annual report, 1979. [Lead abstract]

Rosenthal, M. W. (1979) · doi:10.2172/6783480

Senescence Regulation in Cancer Therapy

Rebbaa, A. (2008) · CRC Press eBooks · doi:10.3109/9781420020502-16

How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Lessons from Biodemographic Analyses of Longitudinal Data

Yashin, A. I., Arbeev, K. G., Wu, D., Kulminski, A. M., Arbeeva, L. S., Kulminskaya, I., Akushevich, I. V., & Ukraintseva, S. V. (2014)

Cellular uptake and actions of bilberry anthocyanins in retinal pigment epithelial cells

Milbury, & Everett, P. (2006) · University of New Hampshire Scholars Repository (University of New Hampshire at Manchester)

Pushing the complexity barrier: diminishing returns in the sciencesPreprint

Gros, C. (2012) · arXiv (Cornell University) · doi:10.48550/arxiv.1209.2725

A Preliminary Mini-Review on the Relations Between Lipofuscin, Aging and the Oxidative Stress Status - the Possible Implications of Gut Functionality

ALI, M. A. M., & Ciobica, A. S. (2020) · Annals of the Academy of Romanian Scientists Series on Biological Sciences · doi:10.56082/annalsarscibio.2020.1.45

Methuselah Proteins in Longevity: Unraveling Their Impact Through Mathematical GenomicsPreprint

Hassan, S. S., Nawn, D., Ghosh, A., Sil, M., Goswami, A., Basu, P., Lundstrom, K. H., & Uversky, V. N. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.11.03.621698

Gene therapy for aging and longevity

Everts, S. P. A., Florea, M., & de Magalhães, J. P. (2026) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2026.05.007

Zelluläre Mechanismen des Alterns

Rensing, L., & Rippe, V. (2013) · Springer eBooks · doi:10.1007/978-3-642-37733-4_2

Aging and longevity genes.

Jazwinski, S. M. (2000) · Acta Biochimica Polonica · doi:10.18388/abp.2000_4007 · Cited by 33

Genetic Determinants of Human Longevity

Dato, S., Soerensen, M., & Rose, G. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-679-6

Current Trends and Approaches to the Search for Genetic Determinants of Aging and Longevity

Станиславовна, К. С., Volobaev, V. P., Plotnikova, M. Y., Kupriyanova, D. A., Kuznetsova, I. L., Tyazhelova, T. V., & Rogaev, E. I. (2022) · Russian Journal of Genetics · doi:10.1134/s1022795422120067 · Cited by 7

QUARTERLY Review Aging and longevity genes �

Jazwinski, S. M. (2000)

Genetics of Human Aging: The Search for Genes Contributing to Human Longevity and Diseases of the Old

Slagboom, P. E., Heijmans, B. T., Beekman, M., Westendorp, R. G. J., & Meulenbelt, I. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06635.x · Cited by 36